SLC12A3 and WNK4

Number of citations of the paper that reports this interaction (PubMedID 12515852)
22

Data Source:
HPRD (in vivo)

		SLC12A3	WNK4
Description		solute carrier family 12 member 3	WNK lysine deficient protein kinase 4
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Renal Sodium Ion Absorption Response To Salt Chloride Transmembrane Transport Response To Aldosterone Potassium Ion Import Across Plasma Membrane	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)	Stimuli-sensing channels
Drugs		Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases			Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS		HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) HDL levels x fish oil supplementation interaction (1df) ( 33760818) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Phoneme awareness ( 30741946)
Interacting Genes		2 interacting genes: PDIA3 WNK4	13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39
Entrez ID		6559	65266
HPRD ID		02984	03505
Ensembl ID		ENSG00000070915	ENSG00000126562
Uniprot IDs		J3QSS1 P55017	Q96J92
PDB IDs		7Y6I 7YG0 7YG1 8FHN 8FHO 8FHP 8FHQ 8FHR 8FHT 8VPN 8VPP 9BWT	2V3S 4CH9 4CHB
Enriched GO Terms of Interacting Partners?		Aldosterone Secretion Disulfide Oxidoreductase Activity Protein Folding In Endoplasmic Reticulum Phospholipase C Activity Cellular Response To Interleukin-7 MHC Class I Peptide Loading Complex Response To Interleukin-7 Tapasin-ERp57 Complex Peptide Antigen Assembly With MHC Class I Protein Complex Nephron Tubule Morphogenesis Negative Regulation Of Sodium Ion Transport Chloride Ion Binding Renal Tubule Morphogenesis Lipid Export From Cell Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Export Across Plasma Membrane Distal Tubule Morphogenesis Ion Channel Inhibitor Activity Intracellular Chloride Ion Homeostasis Response To Dietary Excess Chloride Ion Homeostasis Protein Disulfide Isomerase Activity Monoatomic Anion Homeostasis Renal Sodium Ion Absorption Renal Sodium Ion Transport Protein-disulfide Reductase Activity LncRNA Binding Negative Regulation Of Protein Localization To Plasma Membrane Renal Absorption Platelet Aggregation ERK1 And ERK2 Cascade Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Homotypic Cell-cell Adhesion Macrophage Activation Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Xenobiotic Stimulus Regulation Of Sodium Ion Transport Energy Homeostasis Cell Body Phagocytic Vesicle Regulation Of Potassium Ion Transport Hormone Secretion Recycling Endosome Membrane Melanosome Immune System Process Hormone Transport Negative Regulation Of Monoatomic Ion Transport Chloride Transport Epithelial Tube Morphogenesis	Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules
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