WNK4 and KLHL2

Number of citations of the paper that reports this interaction (PubMedID 24641320)
50

Data Source:
BioGRID (affinity chromatography technology, enzymatic study, unspecified method, x-ray crystallography)

		WNK4	KLHL2
Description		WNK lysine deficient protein kinase 4	kelch like family member 2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity
	Biological Process	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways		Stimuli-sensing channels	Neddylation Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39	30 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID		65266	11275
HPRD ID		03505	09311
Ensembl ID		ENSG00000126562	ENSG00000109466
Uniprot IDs		Q96J92	B4DFZ5 E9PEX9 O95198
PDB IDs		2V3S 4CH9 4CHB	2XN4 4CHB
Enriched GO Terms of Interacting Partners?		Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
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