WNK4 and STK39

Number of citations of the paper that reports this interaction (PubMedID 14563843)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		WNK4	STK39
Description		WNK lysine deficient protein kinase 4	serine/threonine kinase 39
Image
GO Annotations	Cellular Component	Cytoplasm Cytosol Bicellular Tight Junction Membrane Protein-containing Complex Cell Body Anchoring Junction	Nucleus Nucleoplasm Cytoplasm Cytosol Cell Cortex Membrane Basolateral Plasma Membrane Apical Plasma Membrane Cell Body
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Ion Channel Inhibitor Activity Kinase Activity Transferase Activity Chloride Ion Binding Protein Serine Kinase Activity	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Potassium Channel Inhibitor Activity Protein Kinase Binding Transmembrane Transporter Binding Ion Channel Regulator Activity Protein Serine Kinase Activity Transporter Activator Activity Transporter Inhibitor Activity
	Biological Process	Response To Dietary Excess Renal Sodium Ion Transport Protein Phosphorylation Chloride Transport Inflammatory Response Signal Transduction Intracellular Protein Localization Regulation Of Blood Pressure Response To Xenobiotic Stimulus Gene Expression Negative Regulation Of Sodium Ion Transport Intracellular Chloride Ion Homeostasis Intracellular Signal Transduction Sodium Ion Transmembrane Transport Aldosterone Secretion Macrophage Activation Homeostatic Process Monoatomic Ion Homeostasis Calcium Ion Homeostasis Renal Sodium Ion Absorption ERK1 And ERK2 Cascade Cellular Response To Xenobiotic Stimulus Potassium Ion Transmembrane Transport Distal Tubule Morphogenesis Negative Regulation Of Pancreatic Juice Secretion Negative Regulation Of Protein Localization To Plasma Membrane Regulation Of Potassium Ion Export Across Plasma Membrane	Response To Dietary Excess Protein Phosphorylation Cell Volume Homeostasis Inflammatory Response Signal Transduction Regulation Of Blood Pressure Positive Regulation Of T Cell Chemotaxis Peptidyl-serine Phosphorylation Peptidyl-threonine Phosphorylation Intracellular Chloride Ion Homeostasis Negative Regulation Of Transmembrane Transport Intracellular Signal Transduction Sodium Ion Transmembrane Transport Cellular Response To Potassium Ion Maintenance Of Lens Transparency Chemokine (C-X-C Motif) Ligand 12 Signaling Pathway Macrophage Activation Positive Regulation Of Potassium Ion Transport Protein Autophosphorylation Regulation Of Inflammatory Response Monoatomic Ion Homeostasis Renal Sodium Ion Absorption Cellular Hyperosmotic Response Cellular Hypotonic Response Potassium Ion Transmembrane Transport Negative Regulation Of Pancreatic Juice Secretion Positive Regulation Of P38MAPK Cascade Negative Regulation Of Potassium Ion Transmembrane Transport Negative Regulation Of Sodium Ion Transmembrane Transport Positive Regulation Of Potassium Ion Import Across Plasma Membrane Positive Regulation Of Sodium Ion Import Across Plasma Membrane Response To Aldosterone Regulation Of Monoatomic Cation Transmembrane Transport Cellular Response To Chemokine
Pathways		Stimuli-sensing channels
Drugs			Fostamatinib
Diseases		Hyperkalemic distal renal tubular acidosis (RTA type 4), including the following two diseases: Pseudohypoaldosteronism type I (PHA1); Pseudohypoaldosteronism type II (Gordon's syndrome)
GWAS			Blood pressure ( 19114657) Body mass index ( 28552196 28892062) Daytime nap ( 33568662) Macular thickness ( 30535121) Metabolite levels ( 23823483) Parkinson's disease ( 21292315 25064009 27182965 28892059 32201043) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Type 1 diabetes ( 32005708) Weight ( 28552196)
Interacting Genes		13 interacting genes: AKT1 BCL6 CLDN1 CLDN2 CLDN3 CLDN4 HMGB1 KLHL2 KLHL3 NEDD4L OXSR1 SLC12A3 STK39	16 interacting genes: AATK GSN HSPH1 MAPK14 MBP OTOF PRKCQ RELT SLC12A1 SLC12A2 SLC12A6 SPP1 TMEM132D TSC22D2 WNK4 XRN2
Entrez ID		65266	27347
HPRD ID		03505	09627
Ensembl ID		ENSG00000126562	ENSG00000198648
Uniprot IDs		Q96J92	A0A8V8TKT5 Q9UEW8
PDB IDs		2V3S 4CH9 4CHB	7O86
Enriched GO Terms of Interacting Partners?		Renal Absorption Positive Regulation Of Cell Motility Calcium-independent Cell-cell Adhesion Via Plasma Membrane Cell-adhesion Molecules Renal Sodium Ion Transport Renal Sodium Ion Absorption Positive Regulation Of Locomotion Tight Junction Negative Regulation Of Transmembrane Transport Renal System Process Bicellular Tight Junction Assembly Potassium Channel Inhibitor Activity Positive Regulation Of Cell Migration Tight Junction Assembly Tight Junction Organization Positive Regulation Of Wound Healing Structural Molecule Activity Sodium Ion Transport Regulation Of Cell Motility Regulation Of Locomotion Cell-cell Junction Negative Regulation Of Transport Response To Steroid Hormone Response To Ketone Negative Regulation Of Potassium Ion Transmembrane Transport Response To Alcohol Negative Regulation Of Potassium Ion Transport Monoatomic Ion Transport Cell-cell Junction Assembly Bicellular Tight Junction Metal Ion Transport Regulation Of Cell Migration Cell Volume Homeostasis Regulation Of Wound Healing Response To Hormone Regulation Of Mononuclear Cell Migration Response To Corticosteroid Apical Plasma Membrane Inorganic Ion Transmembrane Transport Regulation Of Response To Wounding Cell-cell Junction Organization Monoatomic Cation Transport Monoatomic Ion Transmembrane Transport Cellular Response To Cytokine Stimulus Identical Protein Binding Regulation Of Endodeoxyribonuclease Activity Paracellular Transport Ion Channel Regulator Activity Response To Lipid Homeostatic Process Cell-cell Adhesion Via Plasma-membrane Adhesion Molecules	Monoatomic Anion Homeostasis Chloride Ion Homeostasis Chloride:monoatomic Cation Symporter Activity Sodium:potassium:chloride Symporter Activity Chloride Transport Potassium Ion Transmembrane Transporter Activity Cell Volume Homeostasis Potassium Ion Homeostasis Inorganic Anion Transport Monoatomic Anion Transport Potassium Ion Import Across Plasma Membrane Potassium Ion Transmembrane Transport Potassium Ion Transport Intracellular Chloride Ion Homeostasis Response To Osmotic Stress Regulation Of Cell Size Regulation Of Cellular Component Size Inorganic Cation Import Across Plasma Membrane Chloride Transmembrane Transport Symporter Activity Response To Dietary Excess Inorganic Anion Transmembrane Transport Monoatomic Anion Transmembrane Transport Response To Muscle Stretch Protein Serine Kinase Activity Sodium Ion Transmembrane Transport Import Across Plasma Membrane Protein Serine/threonine Kinase Activity Maintenance Of Blood-brain Barrier Aggresome Inorganic Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transporter Activity Sodium Ion Transport Homeostatic Process Multicellular Organismal-level Homeostasis Renal Absorption Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Positive Regulation Of Metalloendopeptidase Activity Positive Regulation Of T-helper 2 Cell Activation Monoatomic Ion Homeostasis Monoatomic Cation Homeostasis Positive Regulation Of Cell Volume Negative Regulation Of Collateral Sprouting Of Intact Axon In Response To Injury Aldosterone Secretion Protein Kinase Activity Regulation Of Cell-cell Adhesion MAPK Cascade Basolateral Plasma Membrane
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