SLC12A3

Description		solute carrier family 12 member 3
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Binding ATP Binding Sodium:potassium:chloride Symporter Activity Sodium Ion Transmembrane Transporter Activity Symporter Activity Chloride:monoatomic Cation Symporter Activity Sodium:chloride Symporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Sodium Ion Transport Cell Volume Homeostasis Sodium Ion Transmembrane Transport Chloride Ion Homeostasis Potassium Ion Homeostasis Sodium Ion Homeostasis Transmembrane Transport Renal Sodium Ion Absorption Response To Salt Chloride Transmembrane Transport Response To Aldosterone Potassium Ion Import Across Plasma Membrane
Pathways		Cation-coupled Chloride cotransporters Defective SLC12A3 causes Gitelman syndrome (GS)
Drugs		Bendroflumethiazide Metolazone Benzthiazide Indapamide Chlorothiazide Hydrochlorothiazide Trichlormethiazide Polythiazide Quinethazone
Diseases
GWAS		HDL cholesterol ( 20031564 23505323) HDL cholesterol levels ( 26763881) HDL levels x fish oil supplementation interaction (1df) ( 33760818) HDL levels x fish oil supplementation interaction (2df) ( 33760818) Phoneme awareness ( 30741946)
Novel Interacting Genes		2 novel interacting genes: PDIA3 WNK4
Interacting Genes		2 interacting genes: PDIA3 WNK4
Entrez ID		6559
HPRD ID		02984
Ensembl ID		ENSG00000070915
Uniprot IDs		J3QSS1 P55017
PDB IDs		7Y6I 7YG0 7YG1 8FHN 8FHO 8FHP 8FHQ 8FHR 8FHT 8VPN 8VPP 9BWT
Enriched GO Terms of Interacting Partners?		Aldosterone Secretion Disulfide Oxidoreductase Activity Protein Folding In Endoplasmic Reticulum Phospholipase C Activity Cellular Response To Interleukin-7 MHC Class I Peptide Loading Complex Response To Interleukin-7 Tapasin-ERp57 Complex Peptide Antigen Assembly With MHC Class I Protein Complex Nephron Tubule Morphogenesis Negative Regulation Of Sodium Ion Transport Chloride Ion Binding Renal Tubule Morphogenesis Lipid Export From Cell Negative Regulation Of Pancreatic Juice Secretion Regulation Of Potassium Ion Export Across Plasma Membrane Distal Tubule Morphogenesis Ion Channel Inhibitor Activity Intracellular Chloride Ion Homeostasis Response To Dietary Excess Chloride Ion Homeostasis Protein Disulfide Isomerase Activity Monoatomic Anion Homeostasis Renal Sodium Ion Absorption Renal Sodium Ion Transport Protein-disulfide Reductase Activity LncRNA Binding Negative Regulation Of Protein Localization To Plasma Membrane Renal Absorption Platelet Aggregation ERK1 And ERK2 Cascade Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Cysteine-type Endopeptidase Activity Homotypic Cell-cell Adhesion Macrophage Activation Regulation Of Potassium Ion Transmembrane Transport Cellular Response To Xenobiotic Stimulus Regulation Of Sodium Ion Transport Energy Homeostasis Cell Body Phagocytic Vesicle Regulation Of Potassium Ion Transport Hormone Secretion Recycling Endosome Membrane Melanosome Immune System Process Hormone Transport Negative Regulation Of Monoatomic Ion Transport Chloride Transport Epithelial Tube Morphogenesis
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