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KLHL2

Description kelch like family member 2
Image
GO Annotations Cellular Component
  • Ruffle
  • Cytoplasm
  • Cytosol
  • Cytoskeleton
  • Actin Cytoskeleton
  • Lamellipodium
  • Cul3-RING Ubiquitin Ligase Complex
  • Cell Projection
Molecular Function
  • Actin Binding
  • Protein Binding
  • Identical Protein Binding
  • Ubiquitin-like Ligase-substrate Adaptor Activity
Biological Process
  • Protein Ubiquitination
  • Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process
Pathways
  • Neddylation
  • Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS
  • Cognitive function ( 24684796)
  • General cognitive ability ( 29844566)
  • Neuroticism ( 27067015)
Novel Interacting Genes 30 novel interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Interacting Genes 30 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114
Entrez ID 11275
HPRD ID 09311
Ensembl ID ENSG00000109466
Uniprot IDs B4DFZ5 E9PEX9 O95198
PDB IDs 2XN4 4CHB
Enriched GO Terms of Interacting Partners?
  • Negative Regulation Of Pancreatic Juice Secretion
  • Intracellular Chloride Ion Homeostasis
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© Madhavi K. Ganapathiraju 2012-2025