KLHL2 and UCK1

Number of citations of the paper that reports this interaction (PubMedID 33961781)
97

Data Source:
BioGRID (pull down, pull down, imaging technique, enzymatic study, affinity chromatography technology)

		KLHL2	UCK1
Description		kelch like family member 2	uridine-cytidine kinase 1
Image
GO Annotations	Cellular Component	Ruffle Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Cul3-RING Ubiquitin Ligase Complex Cell Projection	Cytoplasm Cytosol
	Molecular Function	Actin Binding Protein Binding Identical Protein Binding Ubiquitin-like Ligase-substrate Adaptor Activity	Nucleotide Binding Uridine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Cytidine Kinase Activity
	Biological Process	Protein Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process	CMP Biosynthetic Process UMP Salvage CTP Salvage
Pathways		Neddylation Antigen processing: Ubiquitination & Proteasome degradation	Pyrimidine salvage
Drugs
Diseases
GWAS		Cognitive function ( 24684796) General cognitive ability ( 29844566) Neuroticism ( 27067015)
Interacting Genes		30 interacting genes: ACTC1 BCAM BYSL CCDC43 CDC37 CIMIP1 CLK2 CWC22 ELOA FRAS1 KLHL12 MFAP1 NAP1L2 NTAQ1 PADI6 PIBF1 POLR3C SDCBP TBKBP1 TMA16 TNPO2 TRIM50 TXNDC12 UBE2C UBE2D1 UBE2I UCK1 WNK1 WNK4 ZNF114	2 interacting genes: KLHL2 PRRC2B
Entrez ID		11275	83549
HPRD ID		09311	18256
Ensembl ID		ENSG00000109466	ENSG00000130717
Uniprot IDs		B4DFZ5 E9PEX9 O95198	A0A024R8E7 A0A0S2Z5Y6 Q9HA47
PDB IDs		2XN4 4CHB	2JEO 2UVQ
Enriched GO Terms of Interacting Partners?		Negative Regulation Of Pancreatic Juice Secretion Intracellular Chloride Ion Homeostasis
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?