PLEKHG2 and XRN1

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		PLEKHG2	XRN1
Description		pleckstrin homology and RhoGEF domain containing G2	5'-3' exoribonuclease 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytosol	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body
	Molecular Function	Guanyl-nucleotide Exchange Factor Activity Protein Binding Small GTPase Binding	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding
	Biological Process	Regulation Of Actin Filament Polymerization	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle RAC1 GTPase cycle	mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA
Drugs
Diseases
GWAS			Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)
Interacting Genes		9 interacting genes: ACTN3 APP B9D2 CDC42 GNG2 PIN1 RAC1 RHOA XRN1	68 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36
Entrez ID		64857	54464
HPRD ID		15148	10470
Ensembl ID		ENSG00000090924	ENSG00000114127
Uniprot IDs		E7ESZ3 Q9H7P9	Q8IZH2
PDB IDs
Enriched GO Terms of Interacting Partners?		Cell Junction Organization Dendrite Positive Regulation Of Supramolecular Fiber Organization Supramolecular Fiber Organization Positive Regulation Of Stress Fiber Assembly Wnt Signaling Pathway, Planar Cell Polarity Pathway Membrane Invagination Non-canonical Wnt Signaling Pathway Postsynapse Positive Regulation Of Actin Filament Bundle Assembly Regulation Of Phosphorus Metabolic Process G Protein Activity G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Negative Regulation Of Oxidative Phosphorylation Small GTPase-mediated Signal Transduction Negative Regulation Of Cellular Respiration Cell Projection Regulation Of Synapse Organization Regulation Of Cytokinesis Thioesterase Binding Positive Regulation Of Phosphate Metabolic Process Regulation Of Stress Fiber Assembly Actin Cytoskeleton Organization Cellular Component Assembly Regulation Of Supramolecular Fiber Organization Actin Filament-based Process Regulation Of Generation Of Precursor Metabolites And Energy Intracellular Signaling Cassette Cellular Response To Catecholamine Stimulus Establishment Of Epithelial Cell Apical/basal Polarity Focal Adhesion Regulation Of Reactive Oxygen Species Metabolic Process Regulation Of Postsynapse Organization Response To Catecholamine Regulation Of Oxidative Phosphorylation Positive Regulation Of Leukocyte Migration GTP-dependent Protein Binding Establishment Of Apical/basal Cell Polarity Polarized Epithelial Cell Differentiation Cytoskeleton Organization Establishment Or Maintenance Of Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Regulation Of Cell Motility Regulation Of Cell Division Positive Regulation Of Lamellipodium Assembly Cell-cell Junction Organization Regulation Of Aerobic Respiration Regulation Of Locomotion Positive Regulation Of Cytoskeleton Organization	Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process
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