XRN1 and CTSB

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)

		XRN1	CTSB
Description		5'-3' exoribonuclease 1	cathepsin B
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body	Extracellular Region Extracellular Space Lysosome Plasma Membrane External Side Of Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Endolysosome Lumen Melanosome Perinuclear Region Of Cytoplasm Extracellular Exosome Peptidase Inhibitor Complex Ficolin-1-rich Granule Lumen
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding	Endopeptidase Activity Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Proteoglycan Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin	Proteolysis Thyroid Hormone Generation Collagen Catabolic Process Epithelial Cell Differentiation Regulation Of Apoptotic Process Decidualization Symbiont Entry Into Host Cell Proteolysis Involved In Protein Catabolic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Collagen degradation Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures MHC class II antigen presentation Neutrophil degranulation Degradation of CDH1
Drugs			2-Aminoethanimidic Acid 3-Amino-4-Oxybenzyl-2-Butanone 3-Methylphenylalanine N-(3-Propylcarbamoyloxirane-2-Carbonyl)-Isoleucyl-Proline 2-Pyridinethiol Diphenylacetic acid N-[1-Hydroxycarboxyethyl-Carbonyl]Leucylamino-2-Methyl-Butane N-{[(2S,3S)-3-(Ethoxycarbonyl)-2-oxiranyl]carbonyl}-L-threonyl-L-isoleucine N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCINE BENZYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE METHYL N-({(2S,3S)-3-[(PROPYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINATE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ALANINE N-{[(2S,3S)-3-(ETHOXYCARBONYL)OXIRAN-2-YL]CARBONYL}-L-ISOLEUCYL-L-ISOLEUCINE N-({(2S,3S)-3-[(BENZYLAMINO)CARBONYL]OXIRAN-2-YL}CARBONYL)-L-ISOLEUCYL-L-PROLINE
Diseases			Tropical calcific pancreatitis
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)	A body shape index ( 34021172) Basophil count ( 32888494) Basophil percentage of white cells ( 32888494) Brain morphology (MOSTest) ( 32665545) C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Dental caries (decayed, missing and filled teeth) ( 31533690) Dilated cardiomyopathy (MTAG) ( 33495596) Fish- and plant-related diet ( 32066663) General risk tolerance (MTAG) ( 30643258) Leprosy ( 27976721) Parkinson's disease ( 28892059 32201043) Parkinson's disease in GBA mutation carriers ( 31755958) Parkinson's disease or first degree relation to individual with Parkinson's disease ( 31701892) Processed meat consumption ( 32066663) Refractive error ( 32231278) Triglyceride levels ( 29083408) Triglycerides ( 30275531) Type 1 diabetes ( 34127860) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172)
Interacting Genes		68 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	40 interacting genes: A2M ACAN ADAMTSL4 ANXA2 ANXA7 APOE APP BAG6 BGLAP CDKN1A CST3 CST7 CSTA CSTB CTSD DSCR9 ERCC6 FAM118B HNRNPD HSPB2 IGF1 INS LCOR LINC00632 MARCKS MTDH PARP1 PLAU REN RGS2 S100A10 SERPINB13 SLPI SPHK1 SPINT2 SPRY2 SRPX2 STK11 UBQLN4 XRN1
Entrez ID		54464	1508
HPRD ID		10470	00287
Ensembl ID		ENSG00000114127	ENSG00000164733
Uniprot IDs		Q8IZH2	A0A024R374 P07858
PDB IDs			1CSB 1GMY 1HUC 1PBH 2IPP 2PBH 3AI8 3CBJ 3CBK 3K9M 3PBH 5MBL 5MBM 6AY2 8B4T 8B5F 8HE9 8HEI 8HEN
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process	Endopeptidase Inhibitor Activity Peptidase Inhibitor Activity Protease Binding Regulation Of Protein Metabolic Process Negative Regulation Of Protein Metabolic Process Regulation Of Proteolysis Negative Regulation Of Metabolic Process Extracellular Space Extracellular Matrix Negative Regulation Of Macromolecule Metabolic Process Extracellular Region Cysteine-type Endopeptidase Inhibitor Activity Positive Regulation Of Protein Metabolic Process Negative Regulation Of Proteolysis Serine-type Endopeptidase Inhibitor Activity Regulation Of Phosphorus Metabolic Process Receptor Ligand Activity Positive Regulation Of Phosphate Metabolic Process Negative Regulation Of Multicellular Organismal Process Regulation Of Multicellular Organismal Process Regulation Of Developmental Process Regulation Of Programmed Cell Death Regulation Of Dendritic Spine Maintenance AnxA2-p11 Complex Lipoprotein Particle Cellular Response To Amyloid-beta Insulin-like Growth Factor Receptor Binding Regulation Of Plasminogen Activation Regulation Of Primary Metabolic Process Regulation Of Apoptotic Process Response To Amyloid-beta Positive Regulation Of Multicellular Organismal Process Regulation Of Cellular Component Organization Negative Regulation Of DNA Metabolic Process Positive Regulation Of Protein Phosphorylation Endosome Lumen Insulin Receptor Binding Positive Regulation Of Glycolytic Process Response To UV-B Regulation Of Protein Catabolic Process Cellular Response To Oxygen-containing Compound Positive Regulation Of Phosphorylation Regulation Of Metabolic Process Regulation Of ATP Metabolic Process Response To Alcohol Cellular Developmental Process Response To UV Extracellular Exosome Positive Regulation Of Plasma Membrane Repair Calcium-dependent Protein Binding
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