XRN1 and EXOSC8

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		XRN1	EXOSC8
Description		5'-3' exoribonuclease 1	exosome component 8
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Exosome (RNase Complex) Fibrillar Center Nucleus Nucleoplasm Chromosome Nucleolus Cytoplasm Cytosol Nucleolar Exosome (RNase Complex) Exoribonuclease Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding	RNA Binding RNA Exonuclease Activity Protein Binding MRNA 3'-UTR AU-rich Region Binding Identical Protein Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin	Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) RRNA Processing RNA Processing RNA Catabolic Process RRNA Catabolic Process U1 SnRNA 3'-end Processing U4 SnRNA 3'-end Processing U5 SnRNA 3'-end Processing Nuclear MRNA Surveillance Nuclear Polyadenylation-dependent RRNA Catabolic Process TRAMP-dependent TRNA Surveillance Pathway
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	ATF4 activates genes in response to endoplasmic reticulum stress mRNA decay by 3' to 5' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA KSRP (KHSRP) binds and destabilizes mRNA Major pathway of rRNA processing in the nucleolus and cytosol Nuclear RNA decay
Drugs
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)
Interacting Genes		68 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	118 interacting genes: AEN ANKHD1 ATF2 C22orf39 CAB39L CCDC28A-AS1 CCL14 CCSER2 CNNM3 COL23A1 COX5A CPSF7 CRMP1 CWC22 DDIT4L DIS3 DUSP23 EEF1DP3 ERAL1 EXOSC1 EXOSC10 EXOSC2 EXOSC4 EXOSC5 EXOSC6 EXOSC7 EXOSC9 FAM161B FAM90A1 FHOD1 FOXD4L1 FOXN3 FRG1 FSAF1 FYTTD1 GEM HAPLN2 HOXB9 ILF2 INCA1 KANK2 KCNJ11 LENG1 LMO4 LNX1 LSM1 LSM4 LSM7 MACIR MAPK8IP1 METTL14 MKRN1 MORN4 MRPL2 MTREX MYOZ1 N4BP2L2 NEDD9 NTAQ1 NXF1 OTUD4 PACSIN2 PALS2 PDCD1LG2 PHF21A PIAS2 PKP2 POLDIP3 PRC1 PRPF31 PRPF6 PRR3 RASD1 RASSF1 RBBP4 RBM22 RBM7 REL RERG RFC5 RPL3 RPLP0 RPP14 RPS28 RUSC1 RXRB SARNP SF1 SFPQ SGO2 SLAIN1 SLIRP SNAI1 SNRPA SNRPB SNRPC SNRPN SNW1 SOCS7 SPATC1L SRPK2 SRSF10 SUGP2 TBRG1 TCEA2 TFAP4 TFIP11 TXNDC17 TXNDC9 UBC UNKL UPF2 USP2 USP6 UTP14A XRN1 XRN2 ZFP36
Entrez ID		54464	11340
HPRD ID		10470	09351
Ensembl ID		ENSG00000114127	ENSG00000120699
Uniprot IDs		Q8IZH2	Q96B26
PDB IDs			2NN6 6D6Q 6D6R 6H25 9G8M 9G8N 9G8O 9G8P
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process	RNA Binding MRNA Metabolic Process Exosome (RNase Complex) RNA Processing RNA Metabolic Process Nuclear Exosome (RNase Complex) Cytoplasmic Exosome (RNase Complex) Nucleic Acid Metabolic Process Nucleolar Exosome (RNase Complex) RNA Splicing, Via Transesterification Reactions Nucleus Nuclear-transcribed MRNA Catabolic Process Nuclear MRNA Surveillance RNA Catabolic Process MRNA Splicing, Via Spliceosome MRNA Catabolic Process RNA Exonuclease Activity MRNA Processing RNA Splicing Nucleoplasm Nucleobase-containing Compound Metabolic Process Spliceosomal Complex Nuclear RNA Surveillance U4 SnRNA 3'-end Processing RNA Surveillance RRNA Catabolic Process 3'-5'-RNA Exonuclease Activity Nucleobase-containing Compound Catabolic Process Nucleic Acid Binding SnRNA Metabolic Process RRNA Metabolic Process RRNA Processing Catalytic Step 2 Spliceosome Poly(A)-dependent SnoRNA 3'-end Processing SnRNA 3'-end Processing Ribonucleoprotein Complex U4/U6 X U5 Tri-snRNP Complex Macromolecule Metabolic Process Nucleolus Exoribonuclease Complex Negative Regulation Of Macromolecule Metabolic Process Exonucleolytic Trimming To Generate Mature 3'-end Of 5.8S RRNA From Tricistronic RRNA Transcript (SSU-rRNA, 5.8S RRNA, LSU-rRNA) TRNA Surveillance TRAMP-dependent TRNA Surveillance Pathway Nuclear Polyadenylation-dependent RRNA Catabolic Process Sno(s)RNA Metabolic Process SnRNA Processing RNA 3'-end Processing Negative Regulation Of Macromolecule Biosynthetic Process Protein Binding
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