XRN1 and LDHA

Number of citations of the paper that reports this interaction (PubMedID 15231747)
47

Data Source:
HPRD (two hybrid)

		XRN1	LDHA
Description		5'-3' exoribonuclease 1	lactate dehydrogenase A
Image		No pdb structure
GO Annotations	Cellular Component	P-body Nucleus Cytoplasm Cytosol Plasma Membrane Membrane Dendrite Neuronal Cell Body	Nucleus Cytoplasm Mitochondrion Cytosol Membrane Sperm Fibrous Sheath Extracellular Exosome Oxidoreductase Complex
	Molecular Function	G-quadruplex RNA Binding Nucleic Acid Binding DNA Binding RNA Binding Nuclease Activity Exonuclease Activity 5'-3' RNA Exonuclease Activity Protein Binding 5'-3' Exonuclease Activity Hydrolase Activity G-quadruplex DNA Binding Telomerase RNA Binding	Catalytic Activity Lactate Dehydrogenase Activity L-lactate Dehydrogenase (NAD+) Activity Protein Binding Oxidoreductase Activity Oxidoreductase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Identical Protein Binding Cadherin Binding
	Biological Process	Nuclear-transcribed MRNA Catabolic Process RNA Metabolic Process RRNA Catabolic Process Negative Regulation Of Translation Negative Regulation Of Telomere Maintenance Via Telomerase Response To Testosterone Nuclear MRNA Surveillance Histone MRNA Catabolic Process Cellular Response To Cycloheximide Cellular Response To Puromycin	Lactate Metabolic Process Glycolytic Process Glucose Catabolic Process To Lactate Via Pyruvate Carboxylic Acid Metabolic Process Substantia Nigra Development Pyruvate Catabolic Process
Pathways		mRNA decay by 5' to 3' exoribonuclease Butyrate Response Factor 1 (BRF1) binds and destabilizes mRNA Tristetraprolin (TTP, ZFP36) binds and destabilizes mRNA	Pyruvate metabolism Regulation of pyruvate metabolism
Drugs			NADH Etheno-NAD Nicotinamide Oxamic Acid Stiripentol Copper Artenimol
Diseases
GWAS		Benign childhood epilepsy with centro-temporal spikes ( 32580138) Birth weight ( 31043758) Caffeine consumption from coffee or tea ( 33287642) Heel bone mineral density ( 30598549) Mean spheric corpuscular volume ( 32888494) Mosquito bite size ( 28199695) Parkinson's disease motor subtype (tremor to postural instability/gait difficulty score ratio) ( 33987465) Waist-hip ratio ( 28552196)	Amyloid A serum levels ( 21124955) Serum metabolite levels ( 33031748)
Interacting Genes		68 interacting genes: ADGRE5 ALDOA ANGPTL6 AP1G2 ATP5MC2 B3GALT6 BAG6 C1GALT1 CBX5 CCT5 CENPBD1P CHD4 CTSB CTSH DCP1B DNASE2 DPP7 DXO EXOSC1 EXOSC10 EXOSC6 EXOSC8 FADS1 FBXO7 GLMP HEATR1 HERC2P4 HNRNPA1 KATNB1 LDHA LEPR LGALS3BP LINC01541 LSM4 MAN2C1 MIR34C MIR429 MIR7-1 MTCH2 MTREX MYH10 NDUFA13 NDUFB10 NDUFB9 PABPC4 PLEKHG2 POLD2 PPP2CA PRADC1 PSMB5 RBMX RNF10 RNF187 SDHB SKIC2 SLC61A1 SMARCD2 SNHG1 SPATA20 SRRM2 STAM2 TMEM50A UPF1 UPF2 UPF3B VWA5B2 WAPL ZFP36	21 interacting genes: ABCC9 ACD CEBPA DUX4 DYNLL1 FGFR1 GSK3A HNRNPD HULC KCNJ11 MAPK10 NDRG1 PCNA POT1 PTPRF SRPK2 TERF1 TINF2 UPF2 XRN1 YWHAQ
Entrez ID		54464	3939
HPRD ID		10470	01025
Ensembl ID		ENSG00000114127	ENSG00000134333
Uniprot IDs		Q8IZH2	P00338 V9HWB9
PDB IDs			1I10 4AJP 4JNK 4L4R 4L4S 4M49 4OJN 4OKN 4QO7 4QO8 4QSM 4QT0 4R68 4R69 4RLS 4ZVV 5IXS 5IXY 5W8H 5W8I 5W8J 5W8K 5W8L 5ZJD 5ZJE 5ZJF 6BAD 6BAG 6BAX 6BAZ 6BB0 6BB1 6BB2 6BB3 6MV8 6MVA 6Q0D 6Q13 6SBU 6SBV 6ZZR 7M2N 8FW6 9BK2 9BK3
Enriched GO Terms of Interacting Partners?		Nucleobase-containing Compound Catabolic Process RNA Catabolic Process Nuclear-transcribed MRNA Catabolic Process MRNA Catabolic Process Macromolecule Catabolic Process Exosome (RNase Complex) Catabolic Process Nuclear Exosome (RNase Complex) Nuclear-transcribed MRNA Catabolic Process, Nonsense-mediated Decay MRNA Metabolic Process Nucleobase-containing Compound Metabolic Process Nucleolar Exosome (RNase Complex) Nuclear MRNA Surveillance Cytoplasmic Exosome (RNase Complex) RNA Exonuclease Activity Positive Regulation Of MRNA Cis Splicing, Via Spliceosome Nuclear RNA Surveillance RNA Surveillance ATP Biosynthetic Process RNA Metabolic Process Negative Regulation Of Gene Expression Nucleoside Triphosphate Biosynthetic Process ATP Metabolic Process Positive Regulation Of MRNA Splicing, Via Spliceosome Nucleic Acid Metabolic Process Proton Motive Force-driven ATP Synthesis MRNA 3'-UTR Binding Purine Ribonucleotide Biosynthetic Process RNA Binding Positive Regulation Of RNA Splicing Generation Of Precursor Metabolites And Energy Ribose Phosphate Biosynthetic Process Supraspliceosomal Complex SnRNA Metabolic Process Purine Nucleotide Biosynthetic Process MRNA Binding Exon-exon Junction Complex Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of Metabolic Process Proton Motive Force-driven Mitochondrial ATP Synthesis Energy Derivation By Oxidation Of Organic Compounds RNA Processing Purine Ribonucleotide Metabolic Process Nucleotide Biosynthetic Process MRNA Transport SnRNA Catabolic Process Ribonucleotide Metabolic Process Regulation Of MRNA Processing RRNA Processing Ribose Phosphate Metabolic Process	Telomeric DNA Binding Regulation Of DNA Biosynthetic Process Regulation Of Telomere Maintenance Via Telomerase Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of Telomere Maintenance Via Telomerase Shelterin Complex Nuclear Telomere Cap Complex Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Telomere Capping Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Telomere Assembly Negative Regulation Of DNA Metabolic Process Positive Regulation Of Telomere Maintenance Positive Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Chromosome Organization Telomere Maintenance Positive Regulation Of Chromosome Organization Negative Regulation Of Biosynthetic Process Regulation Of Chromosome Organization Telomere Organization Negative Regulation Of Macromolecule Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Chromosome, Telomeric Region Response To Metal Ion Telomere Maintenance Via Telomerase Negative Regulation Of Metabolic Process Protein-containing Complex Binding RNA-templated DNA Biosynthetic Process DNA Biosynthetic Process Nucleic Acid Metabolic Process Telomere Maintenance Via Telomere Lengthening Macromolecule Metabolic Process Liver Development Inward Rectifying Potassium Channel Nucleobase-containing Compound Metabolic Process Regulation Of DNA Replication Regeneration ATP-activated Inward Rectifier Potassium Channel Activity Regulation Of Establishment Of Protein Localization To Telomere Positive Regulation Of DNA Biosynthetic Process Response To Xenobiotic Stimulus Positive Regulation Of Organelle Organization Regulation Of Establishment Of Protein Localization To Chromosome Telomerase Inhibitor Activity Establishment Of Protein Localization To Telomere
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