SERPINB3 and CTSL

Number of citations of the paper that reports this interaction (PubMedID 9548757)
0

Data Source:
HPRD (in vitro)

		SERPINB3	CTSL
Description		serpin family B member 3	cathepsin L
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Cytoplasm Cytosol Plasma Membrane Cytoplasmic Vesicle Vesicle Azurophil Granule Lumen Extracellular Exosome	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen
	Molecular Function	Virus Receptor Activity Protease Binding Endopeptidase Inhibitor Activity Serine-type Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding
	Biological Process	Positive Regulation Of Cell Population Proliferation Negative Regulation Of Peptidase Activity Positive Regulation Of Epithelial To Mesenchymal Transition Positive Regulation Of Endopeptidase Activity Negative Regulation Of Endopeptidase Activity Positive Regulation Of Cell Migration Autocrine Signaling Paracrine Signaling Negative Regulation Of Catalytic Activity Negative Regulation Of JUN Kinase Activity Negative Regulation Of Proteolysis Symbiont Entry Into Host Cell	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus
Pathways		Neutrophil degranulation	Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs		D-Serine Dexfosfoserine	L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS
Interacting Genes		7 interacting genes: CDC42 CTSK CTSL CTSS MAPK8 SLC26A4-AS1 UCHL5	29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG
Entrez ID		6317	1514
HPRD ID		02745	00293
Ensembl ID		ENSG00000057149	ENSG00000135047
Uniprot IDs		P29508	P07711 Q5T8F0 Q9HBQ7
PDB IDs		2ZV6 4ZK0 4ZK3	1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC
Enriched GO Terms of Interacting Partners?		Endolysosome Lumen Proteoglycan Binding Cysteine-type Peptidase Activity Fibronectin Binding Collagen Catabolic Process Collagen Metabolic Process Cysteine-type Endopeptidase Activity Collagen Binding Lysosomal Lumen Cellular Response To Thyroid Hormone Stimulus Peptidase Activity Response To Thyroid Hormone Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Proteolysis Involved In Protein Catabolic Process Antigen Processing And Presentation Of Peptide Or Polysaccharide Antigen Via MHC Class II Antigen Processing And Presentation Of Peptide Antigen Via MHC Class II Antigen Processing And Presentation Of Exogenous Peptide Antigen Hydrolase Activity Extracellular Matrix Disassembly Antigen Processing And Presentation Of Exogenous Antigen Antigen Processing And Presentation Of Peptide Antigen Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane JUN Phosphorylation Phagocytic Vesicle Proteolysis Lysosome Antigen Processing And Presentation GBD Domain Binding Storage Vacuole Enkephalin Processing Endothelin Receptor Signaling Pathway Involved In Heart Process Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Basement Membrane Disassembly JUN Kinase Activity Apolipoprotein A-I Receptor Binding Neuropilin Signaling Pathway Serine-type Endopeptidase Activity Chromaffin Granule Elastin Metabolic Process Histone Deacetylase Regulator Activity Basal Dendrite Protein Metabolic Process Protein Processing Hormone Metabolic Process Inflammatory Cell Apoptotic Process Positive Regulation Of Pinocytosis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process	Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process
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