CTSL and COL18A1

Number of citations of the paper that reports this interaction (PubMedID 10716919)
41

Data Source:
HPRD (in vitro)

		CTSL	COL18A1
Description		cathepsin L	collagen type XVIII alpha 1 chain
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Collagen Trimer Basement Membrane Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Extracellular Exosome
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding	Protein Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Identical Protein Binding Metal Ion Binding
	Biological Process	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Skeletal System Development Angiogenesis Endothelial Cell Morphogenesis Cell Adhesion Visual Perception Negative Regulation Of Cell Population Proliferation Response To Xenobiotic Stimulus Anatomical Structure Morphogenesis Animal Organ Morphogenesis Regulation Of Cell Population Proliferation Response To Hydrostatic Pressure
Pathways		Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1	Collagen degradation Activation of Matrix Metalloproteinases Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Integrin cell surface interactions Laminin interactions Collagen chain trimerization
Drugs		L-cysteic acid Felbinac Fostamatinib
Diseases			Vitreoretinal degeneration, including: Stickler syndrome type I (STL1); Stickler syndrome type II (STL2); Snowflake vitreoretinal degeneration (SVD); Wagner syndrome 1 (WGN1); Knobloch syndrome (KNO); Enhanced S-cone syndrome (ESCS); Autosomal dominant vitreoretinochoroidopathy (ADVIRC) Polymicrogyria; Bilateral frontal polymicrogyria (BFP); Bilateral frontoparietal polymicrogyria (BFPP); Bilateral perisylvian polymicrogyria (BPP); Bilateral parasagittal parieto-occipital polymicrogyria (BPOP); Bilateral generalised polymicrogyria (BGP); Unilateral Polymicrogyria (ULP)
GWAS			Ankle injury ( 28957384) Apolipoprotein A1 levels ( 32203549) Blood protein levels ( 30072576) Bone mineral density (total hip) ( 29883787) Brain morphology (MOSTest) ( 32665545) Cardiorespiratory fitness (800m run time) ( 32572135) Early-onset Parkinson's disease ( 28256260) HDL cholesterol levels ( 32203549) Hippocampal atrophy ( 22745009) Left–right brain asymmetry ( 33723403) Platelet distribution width ( 32888494) Pursuit maintenance gain ( 29064472) Total cholesterol levels ( 30275531) Triglycerides ( 24507774 30275531)
Interacting Genes		29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG	20 interacting genes: APP BGN COL1A1 COL4A1 COL6A1 CTSL FBLN2 GPC1 GPC4 HNRNPD ITGA5 ITGAV ITGB1 KDR LAMA1 MMP2 PTEN SPARC TGM2 THBS1
Entrez ID		1514	80781
HPRD ID		00293	00382
Ensembl ID		ENSG00000135047	ENSG00000182871
Uniprot IDs		P07711 Q5T8F0 Q9HBQ7	A0AAG2UW65 A0AAG2UXZ5 P39060
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC	1BNL 3HON 3HSH
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process	Extracellular Matrix Extracellular Region Extracellular Matrix Structural Constituent Extracellular Matrix Binding Fibronectin Binding Cell Surface Regulation Of Cell Migration Regulation Of Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis Anatomical Structure Morphogenesis Positive Regulation Of Locomotion Integrin Binding Developmental Process Cellular Response To Amino Acid Stimulus Angiogenesis Endodermal Cell Differentiation External Side Of Plasma Membrane Regulation Of Cell-substrate Adhesion Response To Amino Acid Cellular Developmental Process Platelet-derived Growth Factor Binding Cell Migration Extracellular Matrix Organization Extracellular Structure Organization Positive Regulation Of Signal Transduction Coreceptor Activity Wound Healing, Spreading Of Epidermal Cells Collagen Metabolic Process Positive Regulation Of Cell Communication Positive Regulation Of Signaling Cell Motility Animal Organ Development Platelet Alpha Granule Integrin Alpha5-beta1 Complex Integrin Alphav-beta1 Complex Regulation Of Angiogenesis Laminin Binding Regulation Of Vasculature Development Positive Regulation Of Angiogenesis Positive Regulation Of Vasculature Development Response To Activity Fibroblast Growth Factor Binding Regulation Of Developmental Process Response To Mechanical Stimulus Cell Adhesion Cell Surface Receptor Signaling Pathway
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