CTSL and CST7

Number of citations of the paper that reports this interaction (PubMedID 9733783)
0

Data Source:
HPRD (in vitro)

		CTSL	CST7
Description		cathepsin L	cystatin F
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Nucleus Lysosome Multivesicular Body Golgi Apparatus Plasma Membrane Membrane Apical Plasma Membrane Extracellular Matrix Cytoplasmic Vesicle Endolysosome Lumen Chromaffin Granule Lysosomal Lumen Extracellular Exosome Endocytic Vesicle Lumen	Extracellular Region Extracellular Space Cytoplasm Lysosome Endosome Late Endosome Multivesicular Body Endoplasmic Reticulum Golgi Apparatus Cytoplasmic Vesicle
	Molecular Function	Fibronectin Binding Cysteine-type Endopeptidase Activity Protein Binding Collagen Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Histone Binding Proteoglycan Binding Serpin Family Protein Binding	Protease Binding Endopeptidase Inhibitor Activity Cysteine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity Protein Homodimerization Activity
	Biological Process	Adaptive Immune Response Proteolysis Protein Autoprocessing Fusion Of Virus Membrane With Host Plasma Membrane Receptor-mediated Endocytosis Of Virus By Host Cell Antigen Processing And Presentation Antigen Processing And Presentation Of Exogenous Peptide Antigen Via MHC Class II Collagen Catabolic Process Zymogen Activation Enkephalin Processing Fusion Of Virus Membrane With Host Endosome Membrane CD4-positive, Alpha-beta T Cell Lineage Commitment Symbiont Entry Into Host Cell Antigen Processing And Presentation Of Peptide Antigen Proteolysis Involved In Protein Catabolic Process Elastin Catabolic Process Macrophage Apoptotic Process Cellular Response To Thyroid Hormone Stimulus	Regulation Of Antigen Processing And Presentation Immune Response Positive Regulation Of Myelination Negative Regulation Of Microglial Cell Activation Lysosomal Protein Catabolic Process
Pathways		Endosomal/Vacuolar pathway Collagen degradation Degradation of the extracellular matrix Trafficking and processing of endosomal TLR Assembly of collagen fibrils and other multimeric structures HS-GAG degradation MHC class II antigen presentation RUNX1 regulates transcription of genes involved in differentiation of keratinocytes Attachment and Entry Attachment and Entry Degradation of CDH1
Drugs		L-cysteic acid Felbinac Fostamatinib
Diseases
GWAS			Alcohol consumption (drinks per week) ( 30643258) Blood protein levels ( 30072576) LDL cholesterol levels in HIV infection ( 33109212)
Interacting Genes		29 interacting genes: ARSA BAG6 BTN3A3 CD7 CD74 COL18A1 CST3 CST7 CSTA CSTB CTSC CUX1 CXCL8 EED GCG GEM IGFBP3 KNG1 MCPH1 PLAU PPP1CC RELB RSPH1 RXRA SERPINB13 SERPINB3 SGTA SLPI TG	3 interacting genes: BMP1 CTSB CTSL
Entrez ID		1514	8530
HPRD ID		00293	04458
Ensembl ID		ENSG00000135047	ENSG00000077984
Uniprot IDs		P07711 Q5T8F0 Q9HBQ7	O76096
PDB IDs		1CJL 1CS8 1ICF 1MHW 2NQD 2VHS 2XU1 2XU3 2XU4 2XU5 2YJ2 2YJ8 2YJ9 2YJB 2YJC 3BC3 3H89 3H8B 3H8C 3HHA 3HWN 3IV2 3K24 3KSE 3OF8 3OF9 4AXL 4AXM 5F02 5I4H 5MAE 5MAJ 5MQY 6EZP 6EZX 6F06 6JD0 6JD8 7QKB 7QKC 7QKD 7W33 7W34 7Z3T 7Z58 7ZS7 7ZVF 7ZXA 8A4U 8A4V 8A4W 8A4X 8A5B 8AHV 8B4F 8C77 8GX2 8HET 8HFV 8OFA 8OZA 8PRX 8QKB 8UAC	2CH9
Enriched GO Terms of Interacting Partners?		Cysteine-type Endopeptidase Inhibitor Activity Endopeptidase Inhibitor Activity Negative Regulation Of Proteolysis Peptidase Inhibitor Activity Regulation Of Proteolysis Extracellular Space Protease Binding Negative Regulation Of Protein Metabolic Process Extracellular Region Endoplasmic Reticulum Lumen Negative Regulation Of Macromolecule Metabolic Process Regulation Of Multicellular Organismal Process Negative Regulation Of Metabolic Process Immune Response Regulation Of Protein Metabolic Process Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Identical Protein Binding Immune System Process Adaptive Immune Response Based On Somatic Recombination Of Immune Receptors Built From Immunoglobulin Superfamily Domains Regulation Of Primary Metabolic Process Regulation Of Myelination Extracellular Exosome Regulation Of Macrophage Activation Adaptive Immune Response Negative Regulation Of Endopeptidase Activity Post-translational Protein Targeting To Endoplasmic Reticulum Membrane Positive Regulation Of Multicellular Organismal Process Negative Regulation Of Peptidase Activity Regulation Of Developmental Process Tail-anchored Membrane Protein Insertion Into ER Membrane Regulation Of Multicellular Organismal Development Positive Regulation Of Proteolysis Regulation Of Microglial Cell Activation Regulation Of Endopeptidase Activity Serine-type Endopeptidase Inhibitor Activity Positive Regulation Of ERAD Pathway Azurophil Granule Lumen Lysosomal Lumen Extracellular Matrix Regulation Of Antigen Processing And Presentation Positive Regulation Of Neutrophil Chemotaxis Regulation Of Nervous System Development Regulation Of ERAD Pathway Regulation Of Viral Life Cycle Positive Regulation Of Granulocyte Chemotaxis Hormone Activity Lymphocyte Mediated Immunity Protein Targeting To ER Negative Regulation Of Protein Catabolic Process	Endolysosome Lumen Proteoglycan Binding Cellular Response To Thyroid Hormone Stimulus Response To Thyroid Hormone Peptidase Activity Collagen Catabolic Process Collagen Metabolic Process Cysteine-type Endopeptidase Activity Collagen Binding Symbiont Entry Into Host Cell Cysteine-type Peptidase Activity Serpin Family Protein Binding Fusion Of Virus Membrane With Host Endosome Membrane Biological Process Involved In Interaction With Host Protein Processing Proteolysis Hormone Metabolic Process Enkephalin Processing Macrophage Apoptotic Process Elastin Catabolic Process Fusion Of Virus Membrane With Host Plasma Membrane Extracellular Space Peptidase Inhibitor Complex Chromaffin Granule Hydrolase Activity Elastin Metabolic Process Protein Maturation Inflammatory Cell Apoptotic Process Cellular Response To Hormone Stimulus Apical Plasma Membrane Extracellular Matrix Extracellular Region Receptor-mediated Endocytosis Of Virus By Host Cell Lysosome Thyroid Hormone Generation Endocytosis Involved In Viral Entry Into Host Cell Regulation Of Hormone Levels Myeloid Cell Apoptotic Process Endocytic Vesicle Lumen Cell Aggregation Cartilage Condensation Thyroid Hormone Metabolic Process Response To Hormone CD4-positive, Alpha-beta T Cell Lineage Commitment Protein Autoprocessing Alpha-beta T Cell Lineage Commitment Decidualization CD4-positive Or CD8-positive, Alpha-beta T Cell Lineage Commitment Proteolysis Involved In Protein Catabolic Process Cellular Developmental Process
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