VARS2 and CMTM5

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		VARS2	CMTM5
Description		valyl-tRNA synthetase 2, mitochondrial	CKLF like MARVEL transmembrane domain containing 5
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Mitochondrion Cytosol	Extracellular Space Membrane
	Molecular Function	Nucleotide Binding Aminoacyl-tRNA Deacylase Activity Aminoacyl-tRNA Ligase Activity Valine-tRNA Ligase Activity Protein Binding ATP Binding Ligase Activity	Cytokine Activity Protein Binding
	Biological Process	Translation TRNA Aminoacylation For Protein Translation Valyl-tRNA Aminoacylation Aminoacyl-tRNA Metabolism Involved In Translational Fidelity	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation
Pathways		Mitochondrial tRNA aminoacylation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Chronic obstructive pulmonary disease ( 33909500) Conotruncal heart defects (maternal effects) ( 28468790) Gestational age at birth (maternal effect) ( 28877031) HIV-1 control ( 20041166) Malaria ( 31844061) Microalbuminuria in type 1 diabetes ( 31537649) Pubertal anthropometrics ( 23449627) Refractive error ( 32231278) Squamous cell lung carcinoma ( 28604730) Ulcerative colitis ( 20848476) Urate levels ( 31578528)
Interacting Genes		8 interacting genes: ABI1 ABI2 ABI3 CMTM5 MAL2 NCK2 PIK3CA SORBS3	133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599
Entrez ID		57176	116173
HPRD ID		11670	06986
Ensembl ID		ENSG00000137411	ENSG00000166091
Uniprot IDs		A0A1U9X9B3 B4DG77 B4E0K6 Q5ST30	Q96DZ9
PDB IDs
Enriched GO Terms of Interacting Partners?		Actin-based Cell Projection SCAR Complex Signaling Adaptor Activity Regulation Of Lamellipodium Assembly Lamellipodium Regulation Of Lamellipodium Organization Regulation Of Actin Filament Organization Regulation Of Actin Cytoskeleton Organization Regulation Of Actin Filament-based Process Regulation Of Supramolecular Fiber Organization Cell Migration Filopodium Tip Neuron Migration Cell Motility Cytoskeletal Anchor Activity Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Supramolecular Fiber Organization Regulation Of Cytoskeleton Organization Positive Regulation Of Lamellipodium Assembly Positive Regulation Of Cytoskeleton Organization Regulation Of Organelle Organization Positive Regulation Of Lamellipodium Organization Regulation Of Cell Projection Assembly Regulation Of Dendritic Spine Morphogenesis Postsynaptic Density Actin Filament Organization Lamellipodium Organization Cell Projection Morphogenesis Peptidyl-tyrosine Phosphorylation Actin Polymerization Or Depolymerization Epidermal Growth Factor Receptor Signaling Pathway ERBB Signaling Pathway Filopodium Cytoskeleton Organization Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Projection Organization Zonula Adherens Assembly Positive Regulation Of Cellular Component Organization Supramolecular Fiber Organization SH3 Domain Binding Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Positive Regulation Of Organelle Organization Response To Butyrate Cellular Response To Hydrostatic Pressure Regulation Of Actin Polymerization Or Depolymerization Phosphatidylinositol 3-kinase Complex, Class IB Regulation Of Translation Initiation In Response To Endoplasmic Reticulum Stress Regulation Of Postsynapse Organization Regulation Of Actin Filament Length Dendritic Spine	Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity
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