CMTM5 and KCNJ6

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		CMTM5	KCNJ6
Description		CKLF like MARVEL transmembrane domain containing 5	potassium inwardly rectifying channel subfamily J member 6
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Golgi Apparatus Plasma Membrane Voltage-gated Potassium Channel Complex Membrane Monoatomic Ion Channel Complex
	Molecular Function	Cytokine Activity Protein Binding	Inward Rectifier Potassium Channel Activity Protein Binding G-protein Activated Inward Rectifier Potassium Channel Activity
	Biological Process	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation	Monoatomic Ion Transport Potassium Ion Transport Monoatomic Ion Transmembrane Transport Regulation Of Monoatomic Ion Transmembrane Transport Potassium Ion Import Across Plasma Membrane
Pathways			Activation of G protein gated Potassium channels Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits
Drugs			Ethanol Halothane Ifenprodil Isavuconazole
Diseases
GWAS			Body size at age 10 ( 32376654) Clostridioides difficle infection ( 33841421) Electroencephalographic traits in alcoholism ( 22554406) Response to placebo treatment in childhood asthma (FVC change) ( 31557306) Rosacea symptom severity ( 29771307)
Interacting Genes		133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599	71 interacting genes: ADRB2 AIG1 APOD BCL2L2 BET1 BIRC5 C14orf180 CMAS CMTM5 CNPY3 COL4A5 CXXC5 DLG1 DRD2 EDDM3B ERG28 FAM20B FIS1 FUNDC2 FXYD6 GABBR1 GIPC1 HMOX2 ICMT ITGAM KCNJ3 KCNJ9 LEPROTL1 LPAR3 LPCAT2 MAP1S MIP MYO15B NINJ2 ORMDL2 PEX11G PEX16 PICK1 PLLP PMP22 PNLIPRP1 PTPRD RPRM RPS6KA2 RTP2 SCAMP4 SCARF1 SCD SERTM1 STATH STRIT1 SYT3 THSD7B TM6SF2 TMEM107 TMEM120B TMEM203 TMEM208 TMEM218 TMPPE TNFRSF10C TSPO2 UBIAD1 UNC50 UPK1B VSTM1 XIAP YIPF1 YIPF6 ZBTB38 ZDHHC24
Entrez ID		116173	3763
HPRD ID		06986	02929
Ensembl ID		ENSG00000166091	ENSG00000157542
Uniprot IDs		Q96DZ9	P48051
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity	Membrane Presynaptic Membrane Trans-synaptic Signaling Synaptic Signaling Endoplasmic Reticulum Membrane Protein Binding Endoplasmic Reticulum Chemical Synaptic Transmission Negative Regulation Of Dopamine Secretion G-protein Activated Inward Rectifier Potassium Channel Activity Compact Myelin Inward Rectifier Potassium Channel Complex Regulation Of Sodium Ion Transport Protein Targeting Regulation Of Presynaptic Membrane Potential Regulation Of Monoatomic Ion Transport Nervous System Process Involved In Regulation Of Systemic Arterial Blood Pressure Golgi Trans Cisterna Negative Regulation Of Synaptic Transmission
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