CMTM5 and TUBB

Number of citations of the paper that reports this interaction (PubMedID 25416956)
56

Data Source:
BioGRID (two hybrid)

		CMTM5	TUBB
Description		CKLF like MARVEL transmembrane domain containing 5	tubulin beta class I
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Extracellular Region Nucleus Nuclear Envelope Lumen Cytoplasm Cytosol Cytoskeleton Microtubule Microtubule Cytoskeleton Protein-containing Complex Azurophil Granule Lumen Cytoplasmic Ribonucleoprotein Granule Cell Body Membrane Raft Intercellular Bridge Extracellular Exosome Mitotic Spindle
	Molecular Function	Cytokine Activity Protein Binding	Nucleotide Binding GTPase Activity Structural Molecule Activity Structural Constituent Of Cytoskeleton Protein Binding GTP Binding Protein Domain Specific Binding Ubiquitin Protein Ligase Binding GTPase Activating Protein Binding MHC Class I Protein Binding Protein-containing Complex Binding Metal Ion Binding
	Biological Process	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation	Microtubule Cytoskeleton Organization Mitotic Cell Cycle Microtubule-based Process Cytoskeleton-dependent Intracellular Transport Natural Killer Cell Mediated Cytotoxicity Regulation Of Synapse Organization Spindle Assembly Cell Division Odontoblast Differentiation
Pathways			Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane Neutrophil degranulation AURKA Activation by TPX2 Potential therapeutics for SARS
Drugs			Vinorelbine Vincristine Vinblastine Podofilox Colchicine Epothilone D Patupilone CYT997 CA4P ZEN-012 Tirbanibulin Copper Artenimol Vinflunine Depatuxizumab mafodotin Milataxel Colchiceine
Diseases
GWAS			Autism spectrum disorder or schizophrenia ( 28540026) Decreased fine motor function in Charcot-Marie-Tooth disease 1A (eating with utensils) ( 30958311) Handedness (non-right-handed vs right-handed) ( 31504236) Left-handedness ( 32989287) Left–right brain asymmetry ( 33723403) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599	85 interacting genes: ADAP2 ALDOA APP ARL8B ATXN3 B4GALT1 BCL2L13 BMPR2 BRCA1 CDH16 CDK1 CDKN2A CLIP1 CMTM5 CNN1 CREBBP CRIPT DISC1 DPYSL2 DUX4 DYNLL1 EML4 ESR1 FXR1 GDAP1 GRM1 HDAC6 HGS HTRA2 HTT LINC01554 LNX2 MAGEA2B MAL2 MAP1A MAP3K10 MAP4 MAP6 MAPRE1 MAPT MARK4 MRGBP MTNR1A MX1 NCALD NCAM1 NCAPH2 NDEL1 NPHP1 OGT PFDN4 PLK1 PRKN PRMT1 PTEN RAB8B RACK1 RASSF1 RSPH1 S100A8 S100A9 SDC3 SPP1 STAU1 SUMO2 SYT9 TAOK2 TBCD TBKBP1 TGM2 TINF2 TPPP TTBK1 TTK TUBA1A UBE3A USP25 VAV1 YWHAB YWHAG YWHAQ YWHAZ ZAP70 ZFYVE21 ZMYND19
Entrez ID		116173	203068
HPRD ID		06986	01852
Ensembl ID		ENSG00000166091	ENSG00000196230
Uniprot IDs		Q96DZ9	B4DMJ5 B4DQN9 B4DY90 P07437 Q5ST81 Q5SU16
PDB IDs			3QNZ 3QO0 5N5N 6I2I 6QUS 6QUY 6QVE 6QVJ 7TRG 7TTN 7TTT 7TUB 7X0S 8BPO 8T42 8U3Z 8V2J 9BP6
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity	Microtubule-based Process Microtubule Cytoskeleton Organization Organelle Organization Microtubule Binding Microtubule Regulation Of Cellular Component Organization Cytoskeleton Organization Microtubule Polymerization Tubulin Binding Identical Protein Binding Microtubule Cytoskeleton Microtubule Associated Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Microtubule Polymerization Or Depolymerization Cytoskeleton Cytosol Neuron Projection Regulation Of Ubiquitin-dependent Protein Catabolic Process Beta-tubulin Binding Regulation Of Organelle Organization Cytoplasm Cytoskeleton-dependent Intracellular Transport Protein Polymerization Positive Regulation Of Intracellular Signal Transduction Regulation Of Proteolysis Axon Protein Localization To Organelle Transport Along Microtubule Regulation Of Protein Localization Supramolecular Fiber Organization Positive Regulation Of Cellular Component Organization Regulation Of Signaling Regulation Of Cell Communication Positive Regulation Of Signal Transduction Regulation Of Growth Regulation Of Cellular Response To Stress Apoptotic Process Dendrite Alpha-tubulin Binding Regulation Of Microtubule-based Process Tau Protein Binding Synapse Programmed Cell Death Cell Death Microtubule-based Transport Regulation Of Microtubule Cytoskeleton Organization Axo-dendritic Transport Regulation Of Intracellular Signal Transduction Cilium Disassembly
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