CMTM5 and GAD1

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid, two hybrid, two hybrid)

		CMTM5	GAD1
Description		CKLF like MARVEL transmembrane domain containing 5	glutamate decarboxylase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Space Membrane	Cytoplasm Plasma Membrane Cell Cortex Vesicle Membrane Axon Axon Terminus Neuron Projection Terminus Synapse Perinuclear Region Of Cytoplasm Presynaptic Active Zone Inhibitory Synapse Clathrin-sculpted Gamma-aminobutyric Acid Transport Vesicle Membrane Presynapse GABA-ergic Synapse
	Molecular Function	Cytokine Activity Protein Binding	Glutamate Decarboxylase Activity Protein Binding Lyase Activity Carbon-carbon Lyase Activity Carboxy-lyase Activity Pyridoxal Phosphate Binding Identical Protein Binding
	Biological Process	Chemotaxis Signal Transduction Negative Regulation Of Myoblast Differentiation	L-glutamate Catabolic Process Gamma-aminobutyrate Shunt Chemical Synaptic Transmission Gamma-aminobutyric Acid Biosynthetic Process Carboxylic Acid Metabolic Process Social Behavior Locomotory Exploration Behavior
Pathways			GABA synthesis GABA synthesis, release, reuptake and degradation MECP2 regulates transcription of genes involved in GABA signaling
Drugs			Pyridoxal phosphate Pyridoxal phosphate Glutamic acid
Diseases			Cerebral palsy
GWAS			Menopause (age at onset) ( 26414677)
Interacting Genes		133 interacting genes: AACS ABHD4 ACSF2 ACSM1 ALDH18A1 APOA1 APOA4 APOA5 AQP6 ARFIP1 ARFIP2 ARMC9 BIK BNIP3 CAPNS2 CD160 CD40 CD79A CLDN7 COQ8A CPLX1 CPLX4 CREB3 CYP1A1 DDA1 DHRSX ECPAS ELOVL4 ERGIC3 FAM114A1 FARS2 FCGR2A FCRL3 FERMT2 FFAR2 FNDC9 GAD1 GAD2 GJB1 GLTP GOLGA2P10 GPR42 GPX8 GTF3C1 HNRNPK HSD17B13 JAGN1 JOSD2 KASH5 KCNJ6 KCNK5 KIR3DL3 LEUTX LMNA LMO2 LNX1 LRRC4C LRRC59 MCEE MCEMP1 MCFD2 MEOX2 MFF MGST3 MIEF1 MRM1 MRRF MTERF3 MTIF3 MYG1 NDRG4 NFU1 NTAQ1 PBX3 PCNA PIMREG PITPNC1 PLIN3 PNPO POLL PPIF PPP2R3C PSCA PTPN9 RBFA REEP2 RETREG3 RHBDD1 RMDN2 RNF185 RSRC2 RUSF1 SAR1A SCARA5 SCN3B SDCBP SGCB SH3GL1 SH3GLB1 SHMT2 SLC10A6 SLC18A2 SLC30A4 SLC35H1 SLC7A14 SNX1 SPATA8 SPG21 SSX3 SSX5 STING1 STOM SUCLA2 SYNE4 SYT16 TBRG4 THAP4 TIMM44 TLCD4 TMED8 TMEM139 TMEM14B TMEM35A TMEM80 TMF1 TPD52L3 TSPAN31 TTPA TUBB TUFM VARS2 ZNF391 ZNF599	19 interacting genes: AGTRAP BASP1 CALM1 CMTM5 GAD2 HAAO KRT31 KRT40 KRTAP3-2 MAL2 PPP2CA PPP2CB PRKACA PRKCE SNCA STK3 TH TRIM23 TRIP6
Entrez ID		116173	2571
HPRD ID		06986	12011
Ensembl ID		ENSG00000166091	ENSG00000128683
Uniprot IDs		Q96DZ9	A0A0S2Z3V5 Q8IVA8 Q99259
PDB IDs			2OKJ 3VP6
Enriched GO Terms of Interacting Partners?		Protein Binding Mitochondrion Mitochondrial Matrix Phosphatidylcholine-sterol O-acyltransferase Activator Activity Identical Protein Binding Lipid Binding Succinate Metabolic Process Mitochondrial Outer Membrane Membrane Endoplasmic Reticulum Membrane Gamma-aminobutyrate Shunt Glutamate Decarboxylase Activity Chylomicron Phospholipid Efflux Small Molecule Biosynthetic Process Low-density Lipoprotein Particle Regulation Of Mitochondrion Organization Regulation Of Release Of Cytochrome C From Mitochondria Endoplasmic Reticulum-autophagosome Adaptor Activity Phospholipid Binding Ligase Activity	Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Cytoskeleton Negative Regulation Of Glycolytic Process Through Fructose-6-phosphate Regulation Of Sequestering Of Calcium Ion Tau Protein Binding Regulation Of Calcium Ion Transmembrane Transport Response To Metal Ion Dopamine Biosynthetic Process Regulation Of Microtubule Polymerization Enzyme Activator Activity Cellular Response To Epinephrine Stimulus Regulation Of Calcium Ion Transport Vascular Endothelial Cell Response To Fluid Shear Stress Response To Epinephrine Synaptic Transmission, Dopaminergic Regulation Of Monoatomic Cation Transmembrane Transport Cytosol Keratin Filament Regulation Of Microtubule Polymerization Or Depolymerization FAR/SIN/STRIPAK Complex Negative Regulation Of Glycolytic Process Protein Phosphatase Type 2A Complex Response To Lead Ion Catecholamine Biosynthetic Process Regulation Of Monoatomic Ion Transmembrane Transport Ferrous Iron Binding Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Chemical Synaptic Transmission Negative Regulation Of ATP Metabolic Process Calcium Channel Complex Phosphate-containing Compound Metabolic Process Regulation Of Generation Of Precursor Metabolites And Energy Trans-synaptic Signaling Regulation Of Metal Ion Transport Synaptic Signaling Dopamine Metabolic Process Positive Regulation Of Synaptic Transmission Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Cellular Response To Fluid Shear Stress Cell Communication Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Spindle Pole L-amino Acid Metabolic Process Intermediate Filament Biogenic Amine Biosynthetic Process Amine Biosynthetic Process Regulation Of Microtubule Cytoskeleton Organization Regulation Of Supramolecular Fiber Organization Aromatic Amino Acid Metabolic Process Presynaptic Endocytosis
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