POLE4 and REG3G

		POLE4	REG3G
Description		DNA polymerase epsilon 4, accessory subunit	regenerating family member 3 gamma
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex	Extracellular Region Extracellular Space Cytoplasm
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Carbohydrate Binding Signaling Receptor Activity Peptidoglycan Binding Metal Ion Binding Oligosaccharide Binding
	Biological Process	DNA-templated DNA Replication DNA Biosynthetic Process	MyD88-dependent Toll-like Receptor Signaling Pathway Acute-phase Response Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Response To Peptide Hormone Negative Regulation Of Keratinocyte Differentiation Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Antimicrobial peptides
Drugs		Cladribine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Acute insulin response ( 28490609) Blood protein levels ( 30072576) Body mass index ( 26426971) Contrast sensitivity ( 24152035) Metabolite levels ( 31628463) Schizophrenia x sex interaction ( 34099189)
Interacting Genes		11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A	1 interacting genes: POLE4
Entrez ID		56655	130120
HPRD ID		16238	10137
Ensembl ID		ENSG00000115350	ENSG00000143954
Uniprot IDs		Q9NR33	Q6UW15
PDB IDs
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process	Epsilon DNA Polymerase Complex ATAC Complex DNA-directed DNA Polymerase Activity DNA-templated DNA Replication DNA Biosynthetic Process DNA Replication
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