POLE4 and EVA1A

		POLE4	EVA1A
Description		DNA polymerase epsilon 4, accessory subunit	eva-1 homolog A, regulator of programmed cell death
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex	Lysosome Lysosomal Membrane Endoplasmic Reticulum Endoplasmic Reticulum Lumen Endoplasmic Reticulum Membrane Plasma Membrane Membrane
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	Protein Binding
	Biological Process	DNA-templated DNA Replication DNA Biosynthetic Process	Cardiac Left Ventricle Morphogenesis Energy Reserve Metabolic Process Autophagy Apoptotic Process Heart Development Post-embryonic Development Lung Development TOR Signaling Connective Tissue Replacement
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Post-translational protein phosphorylation
Drugs		Cladribine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Chronotype ( 30696823) Gout ( 32238385) Seborrheic dermatitis ( 29203360)
Interacting Genes		11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A	9 interacting genes: GYPA MAP1LC3B MS4A13 MTNR1B POLE4 PTN SAT1 SGTB TSPAN4
Entrez ID		56655	84141
HPRD ID		16238	07827
Ensembl ID		ENSG00000115350	ENSG00000115363
Uniprot IDs		Q9NR33	Q9H8M9
PDB IDs
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process
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