REG3G and POLE4

		REG3G	POLE4
Description		regenerating family member 3 gamma	DNA polymerase epsilon 4, accessory subunit
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space Cytoplasm	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex
	Molecular Function	Carbohydrate Binding Signaling Receptor Activity Peptidoglycan Binding Metal Ion Binding Oligosaccharide Binding	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity
	Biological Process	MyD88-dependent Toll-like Receptor Signaling Pathway Acute-phase Response Inflammatory Response Positive Regulation Of Cell Population Proliferation Positive Regulation Of Keratinocyte Proliferation Response To Peptide Hormone Negative Regulation Of Keratinocyte Differentiation Defense Response To Gram-positive Bacterium Antimicrobial Humoral Immune Response Mediated By Antimicrobial Peptide Positive Regulation Of Wound Healing	DNA-templated DNA Replication DNA Biosynthetic Process
Pathways		Antimicrobial peptides	Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex
Drugs			Cladribine
Diseases
GWAS		Acute insulin response ( 28490609) Blood protein levels ( 30072576) Body mass index ( 26426971) Contrast sensitivity ( 24152035) Metabolite levels ( 31628463) Schizophrenia x sex interaction ( 34099189)	Venous thromboembolism ( 33592630)
Interacting Genes		1 interacting genes: POLE4	11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A
Entrez ID		130120	56655
HPRD ID		10137	16238
Ensembl ID		ENSG00000143954	ENSG00000115350
Uniprot IDs		Q6UW15	Q9NR33
PDB IDs
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex ATAC Complex DNA-directed DNA Polymerase Activity DNA-templated DNA Replication DNA Biosynthetic Process DNA Replication	Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process
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