POLE4 and B4GALT4

		POLE4	B4GALT4
Description		DNA polymerase epsilon 4, accessory subunit	beta-1,4-galactosyltransferase 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Epsilon DNA Polymerase Complex ATAC Complex	Golgi Membrane Extracellular Region Golgi Apparatus Membrane
	Molecular Function	DNA Binding DNA-directed DNA Polymerase Activity Protein Binding Protein Heterodimerization Activity	N-acetyllactosamine Synthase Activity Protein Binding Galactosyltransferase Activity Transferase Activity Glycosyltransferase Activity UDP-galactosyltransferase Activity Metal Ion Binding
	Biological Process	DNA-templated DNA Replication DNA Biosynthetic Process	Lactosylceramide Biosynthetic Process Carbohydrate Metabolic Process Protein Glycosylation Lipid Metabolic Process Membrane Lipid Metabolic Process Keratan Sulfate Proteoglycan Biosynthetic Process Glycosylation
Pathways		Recognition of DNA damage by PCNA-containing replication complex PCNA-Dependent Long Patch Base Excision Repair Termination of translesion DNA synthesis HDR through Homologous Recombination (HRR) Gap-filling DNA repair synthesis and ligation in GG-NER Dual Incision in GG-NER Dual incision in TC-NER Gap-filling DNA repair synthesis and ligation in TC-NER DNA replication initiation Activation of the pre-replicative complex	Keratan sulfate biosynthesis N-Glycan antennae elongation
Drugs		Cladribine	N-Acetylglucosamine
Diseases
GWAS		Venous thromboembolism ( 33592630)	Clozapine-induced cytotoxicity ( 25656473) First year height change in growth hormone-treated short stature ( 32652002) Gemcitabine-induced early high-grade neutropenia in pancreatic cancer ( 30889042) Survival in pancreatic cancer ( 28470677)
Interacting Genes		11 interacting genes: B4GALT4 EVA1A HSPA13 NFYB POLE POLE2 POLE3 PRKAR1B REG3G SGO1 UBE3A	4 interacting genes: GOLPH3 GOLPH3L POLE4 TIGIT
Entrez ID		56655	8702
HPRD ID		16238	04930
Ensembl ID		ENSG00000115350	ENSG00000121578
Uniprot IDs		Q9NR33	B2RAZ5 B3KM35 E7ETS9 O60513
PDB IDs
Enriched GO Terms of Interacting Partners?		Epsilon DNA Polymerase Complex DNA-directed DNA Polymerase Activity Leading Strand Elongation DNA-templated DNA Replication DNA Biosynthetic Process DNA Strand Elongation Involved In DNA Replication DNA Strand Elongation DNA Replication DNA Synthesis Involved In DNA Repair Sperm Entry Positive Regulation Of Golgi Lumen Acidification Lactosylceramide Biosynthetic Process	Golgi Vesicle Budding Cargo Adaptor Activity Protein Targeting To Golgi Apparatus Golgi Cisterna Phosphatidylinositol-4-phosphate Binding Golgi To Plasma Membrane Protein Transport Vesicle Budding From Membrane Retrograde Vesicle-mediated Transport, Golgi To Endoplasmic Reticulum Establishment Of Protein Localization To Plasma Membrane Golgi To Plasma Membrane Transport Golgi Cisterna Membrane Post-Golgi Vesicle-mediated Transport Golgi Organization Vesicle-mediated Transport To The Plasma Membrane Positive Regulation Of Protein Secretion Asymmetric Golgi Ribbon Formation Protein Localization To Plasma Membrane Trans-Golgi Network Cell Adhesion Molecule Production Cellular Response To Rapamycin Protein Targeting Establishment Of Protein Localization To Membrane Protein Retention In Golgi Apparatus Protein Localization To Cell Periphery Epsilon DNA Polymerase Complex Positive Regulation Of Protein Transport Regulation Of Protein Secretion Response To Rapamycin Golgi Vesicle Transport Positive Regulation Of Secretion By Cell Vesicle Organization Positive Regulation Of Secretion Positive Regulation Of Establishment Of Protein Localization Protein Localization To Membrane Lipid Binding Establishment Of Protein Localization To Organelle Golgi Ribbon Formation Cellular Response To Ether ATAC Complex Regulation Of Protein Transport Positive Regulation Of Protein Localization Negative Regulation Of Interleukin-12 Production Leukocyte Tethering Or Rolling DNA-directed DNA Polymerase Activity Response To Ether Localization Within Membrane Regulation Of Establishment Of Protein Localization Leukocyte Adhesion To Vascular Endothelial Cell Negative Regulation Of Natural Killer Cell Mediated Cytotoxicity Regulation Of Secretion By Cell
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