PRKAR2A and NBEA

Number of citations of the paper that reports this interaction (PubMedID 11102458)
56

Data Source:
HPRD (in vitro, in vivo)

		PRKAR2A	NBEA
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	neurobeachin
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Protein Kinase Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Intracellular Protein Localization
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile) ( 28679651) Immunoglobulin light chain (AL) amyloidosis (serum IgG profile) ( 28679651) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Non-muscle-invasive bladder cancer tumour size ( 31277774) Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test) ( 30277614) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Response to antipsychotic treatment in schizophrenia ( 29503163)
Interacting Genes		49 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS GABARAPL2 HYAL1 IFNAR2 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 WEE2-AS1 XCR1	6 interacting genes: BMPR2 DSCR9 DTNBP1 PRKAR2A PRKAR2B STRN4
Entrez ID		5576	26960
HPRD ID		01484	05352
Ensembl ID		ENSG00000114302	ENSG00000172915
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	B3KXQ8 Q5T321 Q8NFP9
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	1MI1
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Neuronal Cell Body CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Dendritic Spine CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Protein Domain Specific Binding Ciliary Base Regulation Of CAMP/PKA Signal Transduction Retina Development In Camera-type Eye Dendrite Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Response To Antipsychotic Drug Glutamatergic Synapse Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Signal Transduction Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Cell Communication Negative Regulation Of Chondrocyte Proliferation Venous Blood Vessel Development Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Axon Extension Involved In Axon Guidance Aortic Valve Development Endochondral Bone Morphogenesis Semi-lunar Valve Development Regulation Of Intracellular Signal Transduction Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Postsynapse Armadillo Repeat Domain Binding Postsynaptic Density Negative Regulation Of Dendritic Spine Development Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process
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