PRKAR2A and RAB32

Number of citations of the paper that reports this interaction (PubMedID 12186851)
43

Data Source:
HPRD (two hybrid, in vitro)

		PRKAR2A	RAB32
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	RAB32, member RAS oncogene family
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Mitochondrion Mitochondrial Outer Membrane Early Endosome Endoplasmic Reticulum Golgi Apparatus Trans-Golgi Network Cytosol Endomembrane System Membrane Phagocytic Vesicle Membrane Organelle Membrane Cytoplasmic Vesicle Early Endosome Lumen Vesicle Melanosome Membrane Melanosome Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Phagocytic Vesicle
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Nucleotide Binding GTPase Activity Protein Binding GTP Binding Hydrolase Activity GTP-dependent Protein Binding AP-2 Adaptor Complex Binding AP-1 Adaptor Complex Binding AP-3 Adaptor Complex Binding BLOC-2 Complex Binding
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Intracellular Protein Transport Mitochondrion Organization Vesicle-mediated Transport Antigen Processing And Presentation Melanosome Organization Endosome To Melanosome Transport Protein Localization To Membrane Phagosome Maturation Melanosome Assembly
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	RAB geranylgeranylation RAB GEFs exchange GTP for GDP on RABs
Drugs		GEM-231
Diseases
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Leprosy ( 22019778 25642632 27976721) Metabolite levels ( 23823483)
Interacting Genes		49 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS GABARAPL2 HYAL1 IFNAR2 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 WEE2-AS1 XCR1	5 interacting genes: CHM DDIT4L LRMDA PPP3R2 PRKAR2A
Entrez ID		5576	10981
HPRD ID		01484	06700
Ensembl ID		ENSG00000114302	ENSG00000118508
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	Q13637
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	4CYM 4CZ2 5OEC 5OED 6FF8
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Protein Geranylgeranylation Rab-protein Geranylgeranyltransferase Complex Rab Geranylgeranyltransferase Activity Protein Prenylation Negative Regulation Of Calcium Ion Import Across Plasma Membrane Penetration Of Zona Pellucida Sperm Mitochondrial Sheath Positive Regulation Of Calcium Ion Import Across Plasma Membrane Calcium-dependent Protein Serine/threonine Phosphatase Regulator Activity Protein Serine/threonine Phosphatase Complex Calcineurin Complex CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Nucleotide-activated Protein Kinase Complex Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Protein Kinase A Catalytic Subunit Binding GDP-dissociation Inhibitor Activity Positive Regulation Of Calcineurin-NFAT Signaling Cascade Melanocyte Differentiation CAMP Binding Pigment Cell Differentiation Positive Regulation Of Calcium Ion Import Negative Regulation Of CAMP/PKA Signal Transduction Calcineurin-mediated Signaling Intracellular Signal Transduction
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