PRKAR2A and RYR2

Number of citations of the paper that reports this interaction (PubMedID 10830164)
0

Data Source:
HPRD (in vitro, in vivo)

		PRKAR2A	RYR2
Description		protein kinase cAMP-dependent type II regulatory subunit alpha	ryanodine receptor 2
Image
GO Annotations	Cellular Component	Cytoplasm Centrosome Cytosol Plasma Membrane Focal Adhesion Axoneme CAMP-dependent Protein Kinase Complex Membrane Nucleotide-activated Protein Kinase Complex Protein-containing Complex Plasma Membrane Raft Extracellular Exosome Ciliary Base	Smooth Endoplasmic Reticulum Plasma Membrane Junctional Sarcoplasmic Reticulum Membrane Membrane Sarcoplasmic Reticulum Sarcomere Z Disc Protein-containing Complex Sarcoplasmic Reticulum Membrane Calcium Channel Complex Sarcolemma
	Molecular Function	Nucleotide Binding CAMP-dependent Protein Kinase Inhibitor Activity Protein Binding CAMP-dependent Protein Kinase Regulator Activity Protein Domain Specific Binding CAMP Binding Ubiquitin Protein Ligase Binding Protein Kinase A Catalytic Subunit Binding	Monoatomic Ion Channel Activity Ryanodine-sensitive Calcium-release Channel Activity Calcium Channel Activity Calcium Ion Binding Protein Binding Calmodulin Binding Intracellularly Gated Calcium Channel Activity Enzyme Binding Protein Kinase Binding Protein Kinase A Catalytic Subunit Binding Protein Kinase A Regulatory Subunit Binding Identical Protein Binding Suramin Binding Transmembrane Transporter Binding Calcium-induced Calcium Release Activity
	Biological Process	Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Intracellular Signal Transduction Negative Regulation Of CAMP/PKA Signal Transduction	Response To Hypoxia Regulation Of Heart Rate Embryonic Heart Tube Morphogenesis Left Ventricular Cardiac Muscle Tissue Morphogenesis Cardiac Muscle Hypertrophy Detection Of Calcium Ion Monoatomic Ion Transport Calcium Ion Transport Intracellular Calcium Ion Homeostasis Striated Muscle Contraction Positive Regulation Of Heart Rate Regulation Of Cardiac Muscle Contraction By Regulation Of The Release Of Sequestered Calcium Ion Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Response To Muscle Activity Calcium-mediated Signaling Response To Caffeine Monoatomic Ion Transmembrane Transport Response To Muscle Stretch Release Of Sequestered Calcium Ion Into Cytosol Positive Regulation Of Sequestering Of Calcium Ion Regulation Of Cytosolic Calcium Ion Concentration Establishment Of Localization In Cell Response To Redox State Transmembrane Transport Regulation Of Cardiac Muscle Contraction Cardiac Muscle Contraction Calcium Ion Transport Into Cytosol Sarcoplasmic Reticulum Calcium Ion Transport Calcium Ion Transmembrane Transport Cellular Response To Caffeine Cellular Response To Epinephrine Stimulus Establishment Of Protein Localization To Endoplasmic Reticulum Ventricular Cardiac Muscle Cell Action Potential Purkinje Myocyte To Ventricular Cardiac Muscle Cell Signaling Cell Communication By Electrical Coupling Involved In Cardiac Conduction Type B Pancreatic Cell Apoptotic Process Calcium Ion Transmembrane Import Into Cytosol Positive Regulation Of The Force Of Heart Contraction Regulation Of AV Node Cell Action Potential Regulation Of SA Node Cell Action Potential Regulation Of Atrial Cardiac Muscle Cell Action Potential Regulation Of Ventricular Cardiac Muscle Cell Action Potential
Pathways		PKA activation PKA activation PKA activation in glucagon signalling DARPP-32 events Glucagon-like Peptide-1 (GLP1) regulates insulin secretion Vasopressin regulates renal water homeostasis via Aquaporins CREB1 phosphorylation through the activation of Adenylate Cyclase Hedgehog 'off' state ROBO receptors bind AKAP5 GPER1 signaling ADORA2B mediated anti-inflammatory cytokines production FCGR3A-mediated IL10 synthesis Factors involved in megakaryocyte development and platelet production High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Stimuli-sensing channels Ion homeostasis
Drugs		GEM-231	Flecainide Tetracaine
Diseases			Catecholaminergic polymorphic ventricular tachycardia Arrhythmogenic right ventricular cardiomyopathy (ARVC)
GWAS		Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Crohn's disease ( 28067908) Depressive symptom (depressed mood) (binary trait) ( 31530331) Depressive symptom (depressed mood) (ordinal trait) ( 31530331) Femur bone mineral density x serum urate levels interaction ( 34046847) Heel bone mineral density ( 30598549) Height ( 31562340) Hip circumference adjusted for BMI ( 34021172) Inflammatory bowel disease ( 28067908) Lipoprotein (a) levels ( 33730874) Morning person ( 30696823) Resting heart rate ( 27798624) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Ulcerative colitis ( 28067908) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)	Acute lymphoblastic leukemia (childhood) ( 19684603) Bipolar disorder and eating disorder ( 26433762) Cerivastatin-induced rhabdomyolysis ( 21386754) cognitive impairment (MMSE score) in Parkinson’s disease ( 33613413) Exercise treadmill test traits ( 17903301) General risk tolerance (MTAG) ( 30643258) Hippocampal volume ( 31530798) Hypertension ( 17554300) Lipid traits ( 24386095 30576415) Lung function (FEV1) ( 30061609) Lung function (FVC) ( 30061609) Metabolite levels ( 23823483) Obesity-related traits ( 23251661) Postoperative stroke after cardiac surgery ( 30678657) PR interval ( 32439900) Response to taxane treatment (docetaxel) ( 23006423) Smoking initiation (ever regular vs never regular) ( 30679032)
Interacting Genes		49 interacting genes: AKAP1 AKAP10 AKAP11 AKAP12 AKAP13 AKAP14 AKAP3 AKAP4 AKAP5 AKAP6 AKAP7 AKAP8 AKAP9 APBB1 ARFGEF2 CBFA2T3 CDK1 CFTR EZR FOS GABARAPL2 HYAL1 IFNAR2 LRIF1 MAP2 MSN MYCBPAP NBEA OGT P4HA2 PJA2 PPP1CB PRKACA PRKX RAB32 RACK1 RBM6 RET RPL29 RUNX1T1 RYR2 SCTR SEMG2 SMAD3 SMAD4 TCAIM WASF1 WEE2-AS1 XCR1	21 interacting genes: AKAP6 ALB CACNA1C CACNA1D FKBP1B HOMER1 HSPB2 ITPR1 JPH3 JPH4 KCNN4 LINC00839 MDM2 PRKACA PRKAR2A PSEN1 RYR1 RYR3 SMAD5 SRI UBE2C
Entrez ID		5576	6262
HPRD ID		01484	01619
Ensembl ID		ENSG00000114302	ENSG00000198626
Uniprot IDs		A0A024R2W3 A0A0S2Z472 A0A9L9PY56 A8KAH7 P13861	Q92736
PDB IDs		2IZX 2KYG 4ZP3 5H78 5XBY 8S8O	4JKQ 6Y4O 6Y4P 7KL5 7U9Q 7U9R 7U9T 7U9X 7U9Z 7UA1 7UA3 7UA4 7UA5 7UA9 8UQ2 8UQ3 8UQ4 8UQ5 8UXC 8UXE 8UXF 8UXG 8UXH 8UXI 8UXL 8UXM
Enriched GO Terms of Interacting Partners?		Protein Kinase A Regulatory Subunit Binding Protein Kinase A Binding Regulation Of Protein Kinase A Signaling CAMP-dependent Protein Kinase Complex Cellular Response To Oxygen-containing Compound Positive Regulation Of Intracellular Transport Response To Purine-containing Compound Response To CAMP Positive Regulation Of Transport Positive Regulation Of Protein Localization Cellular Response To CAMP Regulation Of Protein Catabolic Process Cellular Response To Glucose Stimulus Signal Transduction Regulation Of Cellular Localization Cellular Response To Carbohydrate Stimulus Intracellular Signaling Cassette Intracellular Signal Transduction Adenylate Cyclase Binding Intracellular Glucose Homeostasis Positive Regulation Of Protein Transport Regulation Of Protein Localization Protein Kinase A Catalytic Subunit Binding Regulation Of Intracellular Transport Molecular Adaptor Activity GABA Receptor Binding Cell Surface Receptor Protein Serine/threonine Kinase Signaling Pathway Sperm Capacitation Left Ventricular Cardiac Muscle Tissue Morphogenesis Dendritic Branch Response To Glucose Positive Regulation Of Establishment Of Protein Localization Protein Kinase Binding Response To Monosaccharide Positive Regulation Of Protein Kinase A Signaling SMAD Protein Signal Transduction MAPK Cascade Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Calcium Channel Complex R-SMAD Binding Multicellular Organismal-level Water Homeostasis Membrane To Membrane Docking Regulation Of Multicellular Organismal Process Regulation Of Transport Response To Carbohydrate Intracellular Chemical Homeostasis Negative Regulation Of Cell Growth CAMP-dependent Protein Kinase Activity Positive Regulation Of Intracellular Protein Transport Cellular Response To Growth Factor Stimulus	Regulation Of Sequestering Of Calcium Ion Calcium Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol By Sarcoplasmic Reticulum Regulation Of Calcium Ion Transport Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Transmembrane Transport Regulation Of Metal Ion Transport Regulation Of Release Of Sequestered Calcium Ion Into Cytosol Regulation Of Calcium Ion Transmembrane Transport Regulation Of Monoatomic Cation Transmembrane Transport Calcium-mediated Signaling Regulation Of Monoatomic Ion Transport Metal Ion Transport Regulation Of Monoatomic Ion Transmembrane Transport Regulation Of Heart Contraction Calcium Channel Complex Z Disc Sarcoplasmic Reticulum Monoatomic Cation Transport Junctional Sarcoplasmic Reticulum Membrane Regulation Of Blood Circulation Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Regulation Of Cardiac Muscle Contraction Calcium Channel Activity Inorganic Cation Transmembrane Transport Monoatomic Cation Transmembrane Transport System Process Regulation Of Striated Muscle Contraction Monoatomic Ion Transport Regulation Of Heart Rate Inorganic Ion Transmembrane Transport Muscle Contraction Regulation Of Transport Monoatomic Ion Transmembrane Transport Regulation Of System Process Smooth Endoplasmic Reticulum Regulation Of Muscle System Process Muscle System Process Regulation Of Muscle Contraction Protein Tetramerization Sarcoplasmic Reticulum Membrane Intracellularly Gated Calcium Channel Activity Intracellular Signal Transduction T-tubule Positive Regulation Of Transport Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol By Endoplasmic Reticulum Intracellular Signaling Cassette Calcium Ion Transport Into Cytosol Regulation Of Protein Transport
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