NBEA and STRN4

Number of citations of the paper that reports this interaction (PubMedID 16169070)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid)

		NBEA	STRN4
Description		neurobeachin	striatin 4
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Trans-Golgi Network Cytosol Plasma Membrane Endomembrane System Membrane	Cytoplasm Dendrite Protein-containing Complex Neuronal Cell Body Dendritic Spine FAR/SIN/STRIPAK Complex Postsynapse Glutamatergic Synapse GABA-ergic Synapse
	Molecular Function	Protein Kinase Binding	Protein Binding Calmodulin Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Protein-containing Complex Binding Protein Phosphatase 2A Binding Armadillo Repeat Domain Binding
	Biological Process	Intracellular Protein Localization	Negative Regulation Of Hippo Signaling Regulation Of Modification Of Postsynaptic Structure
Pathways		Neurotransmitter receptors and postsynaptic signal transmission PKA activation NOTCH1 Intracellular Domain Regulates Transcription Assembly and cell surface presentation of NMDA receptors
Drugs
Diseases
GWAS		Immunoglobulin light chain (AL) amyloidosis (serum Ig lambda profile) ( 28679651) Immunoglobulin light chain (AL) amyloidosis (serum IgG profile) ( 28679651) Metabolite levels ( 23823483) Nicotine dependence symptom count ( 25555482) Non-muscle-invasive bladder cancer tumour size ( 31277774) Nonsyndromic cleft lip with or without cleft palate x sex interaction (2df test) ( 30277614) Obstructive sleep apnea trait (apnea hypopnea index) ( 29077507) Response to antipsychotic treatment in schizophrenia ( 29503163)	Aspartate aminotransferase levels ( 33547301) Chronic lymphocytic leukemia ( 18758461 28165464) Primary sclerosing cholangitis ( 23603763)
Interacting Genes		6 interacting genes: BMPR2 DSCR9 DTNBP1 PRKAR2A PRKAR2B STRN4	28 interacting genes: AK5 ASNS CALM1 CAV1 CLDN12 CRK DDX39B DFFA ECSIT GDF9 JUN KLHDC2 MAP4K1 MAP4K2 MAP4K3 MAP4K4 MIF MSANTD2 MTG1 NBEA PBDC1 PI4KA PLPPR3 PPBP SLC25A6 TNIK WIPI2 WNT7A
Entrez ID		26960	29888
HPRD ID		05352	18125
Ensembl ID		ENSG00000172915	ENSG00000090372
Uniprot IDs		B3KXQ8 Q5T321 Q8NFP9	F5GYK2 Q59GV6 Q9NRL3
PDB IDs		1MI1
Enriched GO Terms of Interacting Partners?		Neuronal Cell Body CAMP-dependent Protein Kinase Complex CAMP-dependent Protein Kinase Regulator Activity CAMP-dependent Protein Kinase Inhibitor Activity Protein Kinase A Catalytic Subunit Binding Dendritic Spine CAMP Binding Negative Regulation Of CAMP/PKA Signal Transduction Protein Domain Specific Binding Ciliary Base Regulation Of CAMP/PKA Signal Transduction Retina Development In Camera-type Eye Dendrite Negative Regulation Of Cell Proliferation Involved In Heart Valve Morphogenesis Response To Antipsychotic Drug Glutamatergic Synapse Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Regulation Of Signal Transduction Regulation Of Lung Blood Pressure Pulmonary Valve Development Tricuspid Valve Morphogenesis Negative Regulation Of Cell Proliferation Involved In Heart Morphogenesis Activin Receptor Activity, Type II Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Negative Regulation Of Dendritic Spine Morphogenesis Positive Regulation Of Glutamate Secretion, Neurotransmission Regulation Of Cell Communication Negative Regulation Of Chondrocyte Proliferation Venous Blood Vessel Development Regulation Of Signaling Negative Regulation Of Intracellular Signal Transduction Regulation Of Glutamate Secretion, Neurotransmission Positive Regulation Of Axon Extension Involved In Axon Guidance Aortic Valve Development Endochondral Bone Morphogenesis Semi-lunar Valve Development Regulation Of Intracellular Signal Transduction Lymphatic Endothelial Cell Differentiation BMP Receptor Activity Transforming Growth Factor Beta Receptor Activity Mitral Valve Morphogenesis Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Postsynapse Armadillo Repeat Domain Binding Postsynaptic Density Negative Regulation Of Dendritic Spine Development Maternal Placenta Development Lung Vasculature Development Pharyngeal Arch Artery Morphogenesis Endothelial Cell Apoptotic Process	MAP Kinase Kinase Kinase Kinase Activity MAPK Cascade Regulation Of MAPK Cascade JNK Cascade Regulation Of JNK Cascade Intracellular Signaling Cassette Positive Regulation Of MAPK Cascade Positive Regulation Of JNK Cascade Negative Regulation Of Apoptotic Process Positive Regulation Of Intracellular Signal Transduction Kinase Activity Intracellular Signal Transduction Negative Regulation Of Programmed Cell Death Positive Regulation Of Signal Transduction Regulation Of Cell Communication By Electrical Coupling Involved In Cardiac Conduction Cellular Response To Transforming Growth Factor Beta Stimulus Nucleotide Binding ATP Binding Response To Transforming Growth Factor Beta Protein Serine Kinase Activity Protein Phosphorylation Signal Transduction Regulation Of Cell Communication By Electrical Coupling Positive Regulation Of Cell Communication Positive Regulation Of Signaling Phosphorylation Cytokine Activity Regulation Of Fibroblast Proliferation Protein Serine/threonine Kinase Activity Positive Regulation Of Cell Junction Assembly Regulation Of Intracellular Signal Transduction Regulation Of Cardiac Muscle Cell Action Potential
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