BRD2 and H2BC26

Number of citations of the paper that reports this interaction (PubMedID 14731392)
0

Data Source:
HPRD (in vitro, in vivo)

		BRD2	H2BC26
Description		bromodomain containing 2	H2B clustered histone 26
Image
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck	Nucleosome Nucleus Nucleoplasm Chromosome Cytosol
	Molecular Function	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Acetylation-dependent Protein Binding	DNA Binding Structural Constituent Of Chromatin Protein Heterodimerization Activity
	Biological Process	Neural Tube Closure Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Regulation Of Gene Expression Protein Localization To Chromatin T-helper 17 Cell Lineage Commitment Chromatin Looping Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		RUNX3 regulates p14-ARF	Recognition and association of DNA glycosylase with site containing an affected pyrimidine Cleavage of the damaged pyrimidine Recognition and association of DNA glycosylase with site containing an affected purine Recognition and association of DNA glycosylase with site containing an affected purine Cleavage of the damaged purine Cleavage of the damaged purine Meiotic synapsis Packaging Of Telomere Ends Pre-NOTCH Transcription and Translation Formation of the beta-catenin:TCF transactivating complex Formation of the beta-catenin:TCF transactivating complex PRC2 methylates histones and DNA Condensation of Prophase Chromosomes Oxidative Stress Induced Senescence Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence HDACs deacetylate histones HATs acetylate histones HATs acetylate histones SIRT1 negatively regulates rRNA expression ERCC6 (CSB) and EHMT2 (G9a) positively regulate rRNA expression NoRC negatively regulates rRNA expression NoRC negatively regulates rRNA expression B-WICH complex positively regulates rRNA expression DNA methylation Transcriptional regulation by small RNAs Activation of anterior HOX genes in hindbrain development during early embryogenesis Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 Ub-specific processing proteases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks Nonhomologous End-Joining (NHEJ) Processing of DNA double-strand break ends Deposition of new CENPA-containing nucleosomes at the centromere Assembly of the ORC complex at the origin of replication G2/M DNA damage checkpoint RNA Polymerase I Promoter Opening RNA Polymerase I Promoter Escape RUNX1 regulates genes involved in megakaryocyte differentiation and platelet function RUNX1 regulates transcription of genes involved in differentiation of HSCs Estrogen-dependent gene expression Meiotic recombination HCMV Early Events HCMV Late Events Transcriptional regulation of granulopoiesis Inhibition of DNA recombination at telomere Defective pyroptosis Negative Regulation of CDH1 Gene Transcription Amyloid fiber formation Chromatin modifications during the maternal to zygotic transition (MZT) Replacement of protamines by nucleosomes in the male pronucleus MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis MLL4 and MLL3 complexes regulate expression of PPARG target genes in adipogenesis and hepatic steatosis Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by KRAB-ZFP proteins Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by the Human Silencing Hub (HUSH) complex Regulation of endogenous retroelements by Piwi-interacting RNAs (piRNAs) Regulation of PD-L1(CD274) transcription
Drugs
Diseases
GWAS		Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)
Interacting Genes		18 interacting genes: CDC42EP4 CLCN2 DDR1 E2F1 E2F2 ECEL1 H2BC26 H4C16 HLA-DQA1 HOXC6 MECOM PHF1 PKNOX1 PRNP PSMB9 RAC2 SPOP TOP1	5 interacting genes: BRD2 CBX5 CDKN2A RPS6KA5 USP7
Entrez ID		6046	128312
HPRD ID		03326	13661
Ensembl ID		ENSG00000204256	ENSG00000196890
Uniprot IDs		A0A1U9X7A8 E9PIQ3 P25440 X5CF57	Q8N257
PDB IDs		1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5S9O 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6JKE 6K04 6K05 6MO7 6MO8 6MO9 6MOA 6ONY 6SWO 6SWP 6TQ1 6TQ2 6U61 6U71 6U8H 6ULQ 6ULT 6VIY 6WWB 6YTM 6Z7F 6Z8P 6ZB0 6ZB1 6ZB2 7DPN 7DPO 7ENV 7ENZ 7EO5 7JX7 7L6D 7L9G 7L9J 7L9K 7LAK 7NPY 7NPZ 7NQ0 7NQ1 7NQ2 7NQ3 7NQ5 7NQ7 7NQ8 7NQ9 7NQI 7NQJ 7OE4 7OE5 7OE6 7OE8 7OE9 7OEP 7OER 7OES 7OET 7OGY 7Q5O 7USG 7USH 7USI 7UU0 7VRH 7VRI 7VRK 7VRM 7VRO 7VRQ 7VRZ 7VS0 7VS1 7VSF 7WLN 7WMQ 7WMU 7WN5 7WNA 7WNI 8B5G 8B5H 8B5I 8B5J 8CV7 8DNQ 8PX2 8PX8 8SB6 8WYG 8Z69 9FBX	6BIZ
Enriched GO Terms of Interacting Partners?		Lens Fiber Cell Apoptotic Process Rb-E2F Complex DNA Binding	Chromatin Remodeling Chromatin Organization P53 Binding Negative Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Ligase Inhibitor Activity Negative Regulation Of Ubiquitin-dependent Protein Catabolic Process TOR Signaling TORC1 Signaling Histone H2AS1 Kinase Activity Regulation Of RNA Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Signal Transduction By P53 Class Mediator Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Chromosome Acetylation-dependent Protein Binding PML Body Histone H3S28 Kinase Activity Nucleoplasm Negative Regulation Of Proteolysis Positive Regulation Of Macrophage Apoptotic Process Positive Regulation Of Apoptotic Process Involved In Mammary Gland Involution Post-translational Protein Modification Regulation Of Ubiquitin-dependent Protein Catabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Senescence-associated Heterochromatin Focus Protein-containing Complex Regulation Of T Cell Differentiation Apoptotic Process Involved In Mammary Gland Involution Histone H3K14ac Reader Activity Regulation Of DNA-binding Transcription Factor Activity Negative Regulation Of Gene Expression, Epigenetic Symbiont-mediated Disruption Of Host Cell PML Body Histone H3S10 Kinase Activity Negative Regulation Of Protein Neddylation Ubiquitin-protein Transferase Inhibitor Activity Negative Regulation Of Mammary Gland Epithelial Cell Proliferation Negative Regulation Of Biosynthetic Process Negative Regulation Of Immature T Cell Proliferation In Thymus Regulation Of Gene Expression Protein-macromolecule Adaptor Activity Regulation Of Macromolecule Biosynthetic Process Regulation Of Primary Metabolic Process Mitochondrial Depolarization Oncogene-induced Cell Senescence Negative Regulation Of Immature T Cell Proliferation Positive Regulation Of Apoptotic Process Involved In Morphogenesis Protein Stabilization
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?