VGLL1 and PTK7

		VGLL1	PTK7
Description		vestigial like family member 1	protein tyrosine kinase 7 (inactive)
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction
	Molecular Function	Transcription Coactivator Activity Protein Binding	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity
	Biological Process	Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Positive Regulation Of DNA-templated Transcription	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway
Pathways
Drugs
Diseases
GWAS			Coronary artery disease ( 29212778)
Interacting Genes		17 interacting genes: AIRIM CDKN2D HNRNPF LONRF1 MEIS2 PFDN5 PTK7 RIPPLY1 SC5D TEAD1 TEAD2 TEAD3 TEAD4 TEKT4 TLE5 TRIM23 TSSK3	51 interacting genes: BYSL CDC14A CDKN1A CLIC5 CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ENPP5 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PSMB9 PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RPS2 RTN4R STYX TNFRSF21 TPTE TPTE2 TRAM2 VGLL1
Entrez ID		51442	5754
HPRD ID		06751	03534
Ensembl ID		ENSG00000102243	ENSG00000112655
Uniprot IDs		Q99990	Q13308
PDB IDs			6VG3
Enriched GO Terms of Interacting Partners?		Hippo Signaling TEAD-YAP Complex Embryonic Organ Development Transcription Regulator Complex Response To Retinoic Acid	Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation
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