PTK7 and TRAM2

		PTK7	TRAM2
Description		protein tyrosine kinase 7 (inactive)	translocation associated membrane protein 2
Image			No pdb structure
GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Endoplasmic Reticulum Membrane Membrane
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Protein Binding
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	SRP-dependent Cotranslational Protein Targeting To Membrane, Translocation Protein Transport Collagen Biosynthetic Process Protein Insertion Into ER Membrane
Pathways
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Apolipoprotein B levels ( 32203549) Appendicular lean mass ( 33097823) Atopic march ( 26542096) Intraocular pressure ( 29617998) LDL cholesterol levels ( 28334899) Lipid traits (pleiotropy) (HIPO component 2) ( 30289880) Low density lipoprotein cholesterol levels ( 29083408) Total cholesterol levels ( 28334899)
Interacting Genes		51 interacting genes: BYSL CDC14A CDKN1A CLIC5 CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ENPP5 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PSMB9 PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RPS2 RTN4R STYX TNFRSF21 TPTE TPTE2 TRAM2 VGLL1	5 interacting genes: GTF2B GTF2F2 POLR2A PTK7 TBP
Entrez ID		5754	9697
HPRD ID		03534	16338
Ensembl ID		ENSG00000112655	ENSG00000065308
Uniprot IDs		Q13308	A0A024RD84 Q15035
PDB IDs		6VG3
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	RNA Polymerase II General Transcription Initiation Factor Activity Transcription Initiation At RNA Polymerase II Promoter Transcription By RNA Polymerase II DNA-templated Transcription Initiation DNA-templated Transcription RNA Polymerase II Core Promoter Sequence-specific DNA Binding Transcription Factor TFIID Complex Nucleobase-containing Compound Biosynthetic Process Transcription Elongation By RNA Polymerase II MRNA Transcription By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly DNA-templated Transcription Elongation MRNA Transcription Transcription Preinitiation Complex Assembly Promoter-specific Chromatin Binding RNA Metabolic Process Macromolecule Biosynthetic Process Transcriptional Start Site Selection At RNA Polymerase II Promoter RNA Polymerase II, Holoenzyme RNA Polymerase II Core Complex Assembly RNA Polymerase II Transcription Regulator Complex Transcription Factor TFIIF Complex Positive Regulation Of Core Promoter Binding Nucleic Acid Metabolic Process RNA-directed RNA Polymerase Activity RNA-templated Transcription DNA Binding DNA-binding Transcription Factor Binding Germinal Vesicle Protein-DNA Complex Assembly TFIIB-class Transcription Factor Binding Microfibril Binding RNA Polymerase Transcription Factor SL1 Complex Transcription Factor TFIIA Complex Viral Transcription 5'-3' RNA Polymerase Activity RNA Polymerase II General Transcription Initiation Factor Binding Pronucleus Nucleobase-containing Compound Metabolic Process Male Pronucleus Aryl Hydrocarbon Receptor Binding Lung-associated Mesenchyme Development RNA Polymerase I Core Promoter Sequence-specific DNA Binding RNA Polymerase I Preinitiation Complex Assembly Female Pronucleus Meiotic Sister Chromatid Cohesion Positive Regulation Of Transcription Regulatory Region DNA Binding Axon Guidance Receptor Activity RNA Polymerase III General Transcription Initiation Factor Activity Transcription Preinitiation Complex
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