PTK7 and CLIC5

		PTK7	CLIC5
Description		protein tyrosine kinase 7 (inactive)	chloride intracellular channel 5
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Cytoplasm Mitochondrion Golgi Apparatus Centrosome Cytoskeleton Plasma Membrane Cell Cortex Actin Cytoskeleton Membrane Apical Plasma Membrane Stereocilium Monoatomic Ion Channel Complex Chloride Channel Complex Cell Projection Extracellular Exosome
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Chloride Channel Activity Protein Binding Oxidoreductase Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Monoatomic Ion Transport Chloride Transport Female Pregnancy Visual Perception Sensory Perception Of Sound Monoatomic Ion Transmembrane Transport Chloride Transmembrane Transport
Pathways			Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea
Drugs
Diseases
GWAS		Coronary artery disease ( 29212778)	Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cerebrospinal AB1-42 levels in normal cognition ( 29274321) Coronary artery disease in type 1 diabetes ( 32077919) Gout (normal type) ( 32238385) Heel bone mineral density ( 30598549) Intraocular pressure ( 29785010) Itch intensity from mosquito bite ( 28199695) LDL cholesterol levels in HIV infection ( 33109212) Mosquito bite size ( 28199695) Periodontal microbiota ( 22699663)
Interacting Genes		51 interacting genes: BYSL CDC14A CDKN1A CLIC5 CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ENPP5 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PSMB9 PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RPS2 RTN4R STYX TNFRSF21 TPTE TPTE2 TRAM2 VGLL1	9 interacting genes: ACTA1 ACTN1 EZR GSN IQGAP1 LAMTOR5 PTK7 SRPK1 TPRN
Entrez ID		5754	53405
HPRD ID		03534	06292
Ensembl ID		ENSG00000112655	ENSG00000112782
Uniprot IDs		Q13308	A0A2R8YGW2 Q49AE1 Q53G01 Q9NZA1
PDB IDs		6VG3	6Y2H 8Q4I 8Q4J
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Actin Filament Actin Filament Organization Actin Cytoskeleton Focal Adhesion Supramolecular Fiber Organization Actin Filament Binding Cortical Actin Cytoskeleton Ruffle Actin Binding Actin Cytoskeleton Organization S100 Protein Binding Establishment Of Epithelial Cell Apical/basal Polarity Actin Filament-based Process Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity Polarized Epithelial Cell Differentiation Establishment Of Epithelial Cell Polarity Cell-cell Junction Regulation Of Cellular Component Size Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Establishment Or Maintenance Of Apical/basal Cell Polarity Sarcomere Brush Border Actin Filament Bundle Organization Actin Filament Bundle Assembly Regulation Of Plasma Membrane Raft Polarization Phosphatidylinositol 3-kinase Catalytic Subunit Binding Microvillus Cytoskeletal Protein Binding Cytosol Cell Development Plasma Membrane Bounded Cell Projection Organization Filopodium Stress Fiber Structural Constituent Of Postsynapse Positive Regulation Of Protein Processing In Phagocytic Vesicle Establishment Of Cell Polarity Terminal Web Assembly Protein Phosphatase Binding Cytoskeleton Organization Muscle Cell Development Cellular Developmental Process Platelet Morphogenesis Cell Projection Organization Protein Localization To Cell Cortex Intestinal D-glucose Absorption Mitotic Actomyosin Contractile Ring Assembly Actin Filament Organization Stereocilium Maintenance Blood Microparticle
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