PTK7 and PSMB9

		PTK7	PSMB9
Description		protein tyrosine kinase 7 (inactive)	proteasome 20S subunit beta 9
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GO Annotations	Cellular Component	Cytosol Plasma Membrane Cell-cell Junction Focal Adhesion Membrane Axon Neuronal Cell Body Anchoring Junction	Proteasome Complex Nucleus Cytoplasm Cytosol Proteasome Core Complex Proteasome Core Complex, Beta-subunit Complex Extracellular Exosome Spermatoproteasome Complex
	Molecular Function	Protein Kinase Activity Protein Binding ATP Binding Axon Guidance Receptor Activity Coreceptor Activity	Endopeptidase Activity Threonine-type Endopeptidase Activity Protein Binding Peptidase Activity Hydrolase Activity
	Biological Process	Establishment Of Planar Polarity Kidney Development Neural Tube Closure Ventricular Septum Development Axis Elongation Cell Adhesion Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Signal Transduction Axon Guidance Heart Development Positive Regulation Of Neuron Projection Development Wnt Signaling Pathway Cell Migration Actin Cytoskeleton Organization Wound Healing Establishment Of Epithelial Cell Apical/basal Polarity Synapse Organization Convergent Extension Lung-associated Mesenchyme Development Regulation Of Canonical Wnt Signaling Pathway Coronary Vasculature Development Cellular Response To Retinoic Acid Cochlea Morphogenesis Positive Regulation Of Canonical Wnt Signaling Pathway	Immune System Process Proteolysis Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Involved In Protein Catabolic Process
Pathways			ER-Phagosome pathway Cross-presentation of soluble exogenous antigens (endosomes) Proteasome assembly Proteasome assembly Antigen processing: Ub, ATP-independent proteasomal degradation
Drugs			Carfilzomib
Diseases
GWAS		Coronary artery disease ( 29212778)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 23266558) Disc degeneration (lumbar) ( 22993228) Hip circumference adjusted for BMI ( 34021172) IgA nephropathy ( 25305756) Nephropathy ( 21399633) Platelet distribution width ( 27863252) Rosacea symptom severity ( 29771307) Sarcoidosis (non-Lofgren's syndrome without extrapulmonary manifestations) ( 26651848) Systemic lupus erythematosus ( 32771030)
Interacting Genes		51 interacting genes: BYSL CDC14A CDKN1A CLIC5 CLNK CTDSP2 CYSRT1 DUSP10 DUSP14 DUSP15 DUSP18 DUSP19 DUSP21 DUSP26 DUSP29 ENPP5 ERBB2 ILKAP KRTAP1-1 KRTAP1-3 KRTAP10-8 KRTAP5-9 MDFI MTMR1 MTMR10 MTMR6 MTMR9 MTUS2 NBPF19 NOTCH2NLA PPM1A PPM1B PPM1F PPM1K PPP3CA PPP3CB PSMB9 PTEN PTPN11 PTPN12 PTPN6 PTPN7 PTPRR RPS2 RTN4R STYX TNFRSF21 TPTE TPTE2 TRAM2 VGLL1	12 interacting genes: BRD2 CRYGA DDIT4L DYNC1H1 LAGE3 NCOA1 NCOA2 NCOA3 NDUFB9 POMP PSMB10 PTK7
Entrez ID		5754	5698
HPRD ID		03534	01514
Ensembl ID		ENSG00000112655	ENSG00000240065
Uniprot IDs		Q13308	A0A1U9X8D7 P28065
PDB IDs		6VG3	6AVO 6E5B 7AWE 7B12 9FST
Enriched GO Terms of Interacting Partners?		Phosphoprotein Phosphatase Activity Dephosphorylation Protein Serine/threonine Phosphatase Activity Protein Dephosphorylation Protein Tyrosine Phosphatase Activity Hydrolase Activity Phosphate-containing Compound Metabolic Process Phosphatase Activity Protein Tyrosine/serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Cation Binding Peptidyl-tyrosine Dephosphorylation Non-membrane Spanning Protein Tyrosine Phosphatase Activity MAP Kinase Tyrosine/serine/threonine Phosphatase Activity Regulation Of ERK1 And ERK2 Cascade Phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase Activity Protein Modification Process MAP Kinase Phosphatase Activity Phosphatidylinositol Dephosphorylation Regulation Of MAPK Cascade Cytoplasm Phospholipid Dephosphorylation Regulation Of Intracellular Signal Transduction Phosphatidylinositol-3-phosphate Phosphatase Activity Phosphatidylinositol-3,4-bisphosphate 3-phosphatase Activity Negative Regulation Of MAPK Cascade Negative Regulation Of Epithelial Cell Migration Cytosol Phosphatidylinositol Metabolic Process N-terminal Protein Myristoylation Regulation Of Epithelial Cell Migration Negative Regulation Of T Cell Proliferation Negative Regulation Of Signaling Phosphatidylinositol Phosphate Phosphatase Activity Negative Regulation Of ERK1 And ERK2 Cascade Regulation Of Phosphatidylinositol Dephosphorylation Regulation Of Mononuclear Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Negative Regulation Of Calcium Ion Import Across Plasma Membrane Calcineurin Complex Regulation Of Lymphocyte Activation Protein Metabolic Process Negative Regulation Of Lymphocyte Proliferation Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Activation Negative Regulation Of Mononuclear Cell Proliferation Negative Regulation Of Neutrophil Activation Negative Regulation Of Developmental Growth Regulation Of Oligodendrocyte Differentiation	Cellular Response To Thyroglobulin Triiodothyronine Nuclear Receptor Binding Response To Thyroglobulin Triiodothyronine Peroxisome Proliferator Activated Receptor Signaling Pathway Positive Regulation Of Adipose Tissue Development Nuclear Receptor-mediated Signaling Pathway Regulation Of Adipose Tissue Development Protein-lysine-acetyltransferase Activity Protein Dimerization Activity Histone Acetyltransferase Activity Response To Progesterone Intracellular Receptor Signaling Pathway MRNA Transcription By RNA Polymerase II Positive Regulation Of Transcription From RNA Polymerase II Promoter By Galactose MRNA Transcription Transcription Coactivator Activity Histone H4K5ac Reader Activity Histone H4K12ac Reader Activity Acetylation-dependent Protein Binding Labyrinthine Layer Morphogenesis Regulation Of Cellular Response To Insulin Stimulus Cellular Response To Hormone Stimulus Neural Tube Closure Tube Closure Response To Lipid Positive Regulation Of Female Receptivity Response To Retinoic Acid Histone H3K14ac Reader Activity Response To Estradiol Vitamin D Receptor Signaling Pathway
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