PCM1 and INTS4

Number of citations of the paper that reports this interaction (PubMedID 34133714)
84

Data Source:
BioGRID (two hybrid)

		PCM1	INTS4
Description		pericentriolar material 1	integrator complex subunit 4
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GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium	Nucleus Nucleoplasm Nucleolus Cytoplasm Integrator Complex INTAC Complex
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		62 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DPYSL2 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FGF20 FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PDGFRL PPIE PRC1 PRKCI PRPF6 PXN RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TNFRSF10B TTC8 VPS26C WASHC3 ZNF830	14 interacting genes: ACOT2 ENOX2 FAM181B FOLR1 HGS KIAA0513 LHX3 MEIS3 NARS2 PCM1 PYGM RNF10 USHBP1 ZMIZ2
Entrez ID		5108	92105
HPRD ID		02624	12386
Ensembl ID		ENSG00000078674	ENSG00000149262
Uniprot IDs		A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154	A0A8C8UVZ7 A0A8Q3SHL8 A0A8Q3SHT4 A0A8Q3WKB5 Q96HW7
PDB IDs		6HYL 6HYM 7Q46	7BFP 7BFQ 7CUN 7PKS 7YCX 8R2D 8RBX 8RBZ 8RC4 8YJB
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly
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