PCM1 and FAM81A

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		PCM1	FAM81A
Description		pericentriolar material 1	family with sequence similarity 81 member A
Image			No pdb structure
GO Annotations	Cellular Component	Pericentriolar Material Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cilium Microtubule Cytoskeleton Membrane Nuclear Membrane Protein-containing Complex Centriolar Satellite Ciliary Transition Zone Ciliary Basal Body Cell Projection Apical Part Of Cell Non-motile Cilium	Cytoplasm Postsynaptic Density Synapse Glutamatergic Synapse Postsynaptic Density, Intracellular Component
	Molecular Function	Protein Binding Identical Protein Binding Molecular Adaptor Activity	Protein Binding Molecular Condensate Scaffold Activity
	Biological Process	Neuron Migration Centrosome Cycle Interkinetic Nuclear Migration Cell Projection Organization Cytoplasmic Microtubule Organization Protein Localization To Organelle Microtubule Anchoring Microtubule Anchoring At Centrosome Social Behavior Intraciliary Transport Involved In Cilium Assembly Negative Regulation Of Neurogenesis Cilium Assembly Regulation Of Protein Complex Stability Protein Localization To Centrosome Positive Regulation Of Intracellular Protein Transport Neuronal Stem Cell Population Maintenance Protein-containing Complex Localization To Centriolar Satellite Non-motile Cilium Assembly
Pathways		Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Atrial fibrillation ( 28416818) Economic and political preferences ( 22566634) Heel bone mineral density x serum urate levels interaction ( 34046847) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494) Response to bronchodilator in chronic obstructive pulmonary disease (change in FEV1) ( 26503814) Triglyceride levels ( 32203549) Waist-hip ratio ( 30108283) Weight ( 28552196)	Metabolite levels ( 23823483) Visceral adipose tissue adjusted for BMI ( 22589738)
Interacting Genes		62 interacting genes: ABI1 ABI2 AKAP9 ALG13 APP BACE2 BBS4 BICD2 CASK CCHCR1 CDC42 CDK1 CEBPA CEP72 CYTH4 DDIT3 DDX23 DENND1A DPYSL2 DYNLL1 E2F4 ECPAS EPS8 EXOC8 FAM81A FGF20 FXR2 GABARAP GOLGA2 GRN HAP1 ING5 INTS4 KAT5 KLC1 KLC4 KRT15 KRT19 KRT24 LARP4 LSM2 MCRS1 MORF4L1 NDUFA9 PCNT PDGFRL PPIE PRC1 PRKCI PRPF6 PXN RALBP1 RBM11 RBM5 RINT1 RPA2 TFIP11 TNFRSF10B TTC8 VPS26C WASHC3 ZNF830	7 interacting genes: NAP1L2 PCM1 RCOR3 STX1B TFIP11 TXLNA ZNF655
Entrez ID		5108	145773
HPRD ID		02624	14508
Ensembl ID		ENSG00000078674	ENSG00000157470
Uniprot IDs		A0A4W8VX11 A0A5H1ZRS1 A2RUU9 B9EIS5 E9PGW9 Q15154	Q8TBF8
PDB IDs		6HYL 6HYM 7Q46
Enriched GO Terms of Interacting Partners?		Cytoskeleton Organelle Organization Cytoskeleton Organization Microtubule-based Process Centrosome Supramolecular Fiber Organization Positive Regulation Of Organelle Organization Cytosol Spliceosomal Complex Microtubule Cytoskeleton Organization Centriolar Satellite Regulation Of Supramolecular Fiber Organization Growth Cone Microtubule Organizing Center Organization Regulation Of Organelle Organization Catalytic Step 2 Spliceosome Cellular Component Assembly Regulation Of Cell Cycle Cellular Response To Stress Microtubule Intracellular Protein Localization Positive Regulation Of Cellular Component Organization Establishment Of Protein Localization CHOP-C/EBP Complex Regulation Of Actin Filament Organization RNA Splicing Cytoplasm Cellular Localization Astrocyte Activation Involved In Immune Response Positive Regulation Of Plasma Membrane Bounded Cell Projection Assembly Sensory Processing Regulation Of Attachment Of Spindle Microtubules To Kinetochore Establishment Of Apical/basal Cell Polarity Establishment Of Monopolar Cell Polarity Establishment Or Maintenance Of Monopolar Cell Polarity MRNA Splicing, Via Spliceosome Histone Acetyltransferase Complex Epithelial Cell Differentiation Protein Transport Mitotic DNA Damage Checkpoint Signaling Regulation Of Cytoskeleton Organization RNA Splicing, Via Transesterification Reactions Mitotic DNA Integrity Checkpoint Signaling Positive Regulation Of Protein Metabolic Process Mitotic Spindle Microtubule Nucleation MRNA Processing Golgi Disassembly Nuclear DNA Replication Organelle Disassembly	Histone Acetyltransferase Regulator Activity Protein-containing Complex Localization To Centriolar Satellite Spliceosomal Complex Disassembly Positive Regulation Of Spontaneous Neurotransmitter Secretion Negative Regulation Of Macropinocytosis Negative Regulation Of Synaptic Vesicle Recycling U2-type Post-mRNA Release Spliceosomal Complex
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