INTS4 and ACOT2

		INTS4	ACOT2
Description		integrator complex subunit 4	acyl-CoA thioesterase 2
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Integrator Complex INTAC Complex	Mitochondrion Mitochondrial Matrix Peroxisomal Matrix Cytosol
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Hydrolase Activity Thiolester Hydrolase Activity Fatty Acyl-CoA Hydrolase Activity Carboxylic Ester Hydrolase Activity
	Biological Process	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance	Very Long-chain Fatty Acid Metabolic Process Long-chain Fatty Acid Metabolic Process Lipid Metabolic Process Fatty Acid Metabolic Process Acyl-CoA Metabolic Process Monocarboxylic Acid Metabolic Process
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	Mitochondrial Fatty Acid Beta-Oxidation Peroxisomal protein import Peroxisomal protein import Mitochondrial protein degradation
Drugs
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Tourette syndrome ( 30818990)	Urinary metabolite levels in chronic kidney disease ( 31959995)
Interacting Genes		14 interacting genes: ACOT2 ENOX2 FAM181B FOLR1 HGS KIAA0513 LHX3 MEIS3 NARS2 PCM1 PYGM RNF10 USHBP1 ZMIZ2	3 interacting genes: INTS4 PEX5 SLC13A1
Entrez ID		92105	10965
HPRD ID		12386	10173
Ensembl ID		ENSG00000149262	ENSG00000119673
Uniprot IDs		A0A8C8UVZ7 A0A8Q3SHL8 A0A8Q3SHT4 A0A8Q3WKB5 Q96HW7	B3KSA0 P49753
PDB IDs		7BFP 7BFQ 7CUN 7PKS 7YCX 8R2D 8RBX 8RBZ 8RC4 8YJB	3HLK
Enriched GO Terms of Interacting Partners?			Peroxisome Membrane Targeting Sequence Binding Peroxisome Matrix Targeting Signal-1 Binding Sodium:sulfate Symporter Activity Monoatomic Anion:sodium Symporter Activity Protein Import Into Peroxisome Matrix, Translocation Peroxisome Targeting Sequence Binding Protein Import Into Peroxisome Matrix, Docking Protein Import Into Peroxisome Membrane Protein Import Into Peroxisome Matrix, Substrate Release Protein Targeting To Peroxisome Protein Import Into Peroxisome Matrix, Receptor Recycling Protein Carrier Chaperone Secondary Active Sulfate Transmembrane Transporter Activity Protein Unfolding Protein Import Into Peroxisome Matrix Pexophagy Sulfate Transmembrane Transport Solute:sodium Symporter Activity INTAC Complex Peroxisomal Membrane Transport Establishment Of Protein Localization To Peroxisome Integrator Complex RNA Polymerase II Transcription Initiation Surveillance Cerebral Cortex Neuron Differentiation Peroxisome Organization Receptor Recycling Intracellular Protein Transmembrane Transport Cerebral Cortex Cell Migration Positive Regulation Of Multicellular Organism Growth SnRNA Processing Very Long-chain Fatty Acid Metabolic Process Nuclear RNA Surveillance Forebrain Neuron Differentiation RNA Surveillance Telencephalon Cell Migration Forebrain Cell Migration Receptor Metabolic Process Peroxisomal Matrix SnRNA Metabolic Process Fatty Acid Beta-oxidation Protein Monoubiquitination Endoplasmic Reticulum Organization Peroxisomal Membrane
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