INTS4 and FOLR1

		INTS4	FOLR1
Description		integrator complex subunit 4	folate receptor alpha
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Nucleolus Cytoplasm Integrator Complex INTAC Complex	Golgi Membrane Extracellular Region Nucleus Endosome Endoplasmic Reticulum Membrane Plasma Membrane External Side Of Plasma Membrane Cell Surface ER To Golgi Transport Vesicle Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Transport Vesicle Clathrin-coated Vesicle Cytoplasmic Vesicle Brush Border Membrane Endoplasmic Reticulum-Golgi Intermediate Compartment Membrane Extracellular Exosome Side Of Membrane
	Molecular Function	Protein Binding Protein-macromolecule Adaptor Activity	Protein Binding Folic Acid Binding Signaling Receptor Activity Folic Acid Receptor Activity
	Biological Process	SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II RNA Polymerase II Transcription Initiation Surveillance	Heart Looping Neural Crest Cell Migration Involved In Heart Formation Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Receptor-mediated Endocytosis Cell Adhesion Fusion Of Sperm To Egg Plasma Membrane Involved In Single Fertilization Folic Acid Transport Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Axon Regeneration Sperm-egg Recognition Tetrahydrofolate Biosynthetic Process Folic Acid Metabolic Process Response To Axon Injury Regulation Of Canonical Wnt Signaling Pathway Pharyngeal Arch Artery Morphogenesis Anterior Neural Tube Closure Cellular Response To Folic Acid
Pathways		RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes	COPII-mediated vesicle transport Cargo concentration in the ER COPI-mediated anterograde transport
Drugs			Folic acid Vintafolide Farletuzumab Mirvetuximab soravtansine Pafolacianine
Diseases
GWAS		Mean reticulocyte volume ( 32888494) Platelet count ( 32888494) Tourette syndrome ( 30818990)
Interacting Genes		14 interacting genes: ACOT2 ENOX2 FAM181B FOLR1 HGS KIAA0513 LHX3 MEIS3 NARS2 PCM1 PYGM RNF10 USHBP1 ZMIZ2	8 interacting genes: CUL3 INTS4 IRAK3 LTB4R2 LYN NCAPH2 PDE2A SLC35F6
Entrez ID		92105	2348
HPRD ID		12386	00638
Ensembl ID		ENSG00000149262	ENSG00000110195
Uniprot IDs		A0A8C8UVZ7 A0A8Q3SHL8 A0A8Q3SHT4 A0A8Q3WKB5 Q96HW7	P15328
PDB IDs		7BFP 7BFQ 7CUN 7PKS 7YCX 8R2D 8RBX 8RBZ 8RC4 8YJB	4KM6 4KM7 4KMX 4LRH 5IZQ
Enriched GO Terms of Interacting Partners?			Regulation Of Cellular Component Organization Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Lipopolysaccharide-mediated Signaling Pathway Nuclear RNA Surveillance RNA Surveillance Positive Regulation Of Chromosome Separation RNA Polymerase II Transcription Initiation Surveillance Mononuclear Cell Differentiation Nucleobase-containing Compound Catabolic Process Positive Regulation Of Macrophage Tolerance Induction Leukocyte Differentiation Regulation Of Chromosome Separation Cytokine-mediated Signaling Pathway Positive Regulation Of Defense Response Positive Regulation Of Oligodendrocyte Progenitor Proliferation Trophectodermal Cellular Morphogenesis Liver Morphogenesis Female Meiosis Chromosome Separation Leukotriene B4 Receptor Activity Response To Amino Acid Negative Regulation Of Catalytic Activity Regulation Of Oligodendrocyte Progenitor Proliferation Pattern Recognition Receptor Signaling Pathway Platelet Degranulation Positive Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Histamine Secretion By Mast Cell Negative Regulation Of Mast Cell Proliferation Negative Regulation Of MAPK Cascade Myeloid Leukocyte Differentiation Fc Receptor Mediated Inhibitory Signaling Pathway Negative Regulation Of Toll-like Receptor 2 Signaling Pathway Eosinophil Differentiation Glycosphingolipid Binding Postsynaptic Specialization, Intracellular Component Positive Regulation Of Mast Cell Proliferation Integrin Alpha2-beta1 Complex Tolerance Induction To Self Antigen Response To Insulin Interleukin-5-mediated Signaling Pathway Positive Regulation Of Dendritic Cell Apoptotic Process 3',5'-cGMP-stimulated Cyclic-nucleotide Phosphodiesterase Activity Regulation Of Mitochondrion Organization Cellular Response To Macrophage Colony-stimulating Factor Stimulus Negative Regulation Of CGMP-mediated Signaling CGMP Catabolic Process Regulation Of Organelle Organization Cellular Response To 2,3,7,8-tetrachlorodibenzodioxine
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