P2RY2 and CD47

Number of citations of the paper that reports this interaction (PubMedID 11331301)
53

Data Source:
HPRD (in vivo)

		P2RY2	CD47
Description		purinergic receptor P2Y2	CD47 molecule
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Cell Surface Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding A1 Adenosine Receptor Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled UTP Receptor Activity	Protein Binding Fibrinogen Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity
	Biological Process	Intracellular Monoatomic Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance	Angiogenesis Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Type II Interferon Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Cell-cell Adhesion ATP Export Positive Regulation Of Monocyte Extravasation
Pathways		G alpha (q) signalling events P2Y receptors Surfactant metabolism High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs		Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Bipolar disorder ( 31043756 33263727 34002096) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)
Interacting Genes		7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC	25 interacting genes: BNIP3 EPB42 FAS GAP43 GNAI1 IGF2BP2 IGSF8 ITGAV MAP3K10 MTIF3 MUC1 P2RY2 PLA1A PTK2 PVR RHAG SIRPA SRC SYNE4 TAGLN3 TFEB THBS1 TMEM167B UBQLN1 ZBTB20
Entrez ID		5029	961
HPRD ID		02499	03017
Ensembl ID		ENSG00000175591	ENSG00000196776
Uniprot IDs		P41231	A0A0A1TSG4 Q08722
PDB IDs			2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU 7MYZ 7WN8 7XJF 7YGG 8RP8
Enriched GO Terms of Interacting Partners?		Integrin Binding Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Wound Healing, Spreading Of Epidermal Cells Regulation Of Endocytosis Symbiont Entry Into Host Cell Cell Adhesion Cell Migration Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Regulation Of Cell Migration Cell-substrate Adhesion Biological Process Involved In Interaction With Host Cell Surface Receptor Signaling Pathway Regulation Of Cell Motility Heterotypic Cell-cell Adhesion Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Adhesion Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Regulation Of Vesicle-mediated Transport Substrate Adhesion-dependent Cell Spreading Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Coreceptor Activity Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Fibrinogen Binding Angiogenesis Response To Interleukin-1 Response To Growth Factor Virus Receptor Activity Signaling Receptor Activator Activity Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis External Side Of Plasma Membrane Positive Regulation Of Mononuclear Cell Migration Ruffle Membrane	Response To Mechanical Stimulus Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Signaling Receptor Activity Ankyrin-1 Complex Integrin Binding Signal Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Hydrogen Peroxide Positive Regulation Of Phosphate Metabolic Process Regulation Of Focal Adhesion Assembly Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cell-substrate Junction Organization Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Positive Regulation Of Fibroblast Migration Positive Regulation Of Metabolic Process Response To Hyperoxia Response To Hydrogen Peroxide Filopodium Membrane Negative Regulation Of Transport Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Anoikis Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Glycolytic Process Cellular Response To Reactive Oxygen Species Cell Motility Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Chemical Stress Multicellular Organismal-level Iron Ion Homeostasis Symbiont Entry Into Host Cell Protein Autophosphorylation Positive Regulation Of Macrophage Migration Regulation Of Anoikis Autophagy Fibronectin Binding Regulation Of Cell Adhesion Extracellular Matrix Binding Regulation Of Cell-matrix Adhesion
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