CD47 and ZBTB20

		CD47	ZBTB20
Description		CD47 molecule	zinc finger and BTB domain containing 20
Image			No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Cell Surface Membrane Specific Granule Membrane Extracellular Exosome Tertiary Granule Membrane	Nucleus Nucleoplasm Cytoplasm Nuclear Body
	Molecular Function	Protein Binding Fibrinogen Binding Thrombospondin Receptor Activity Protein Binding Involved In Heterotypic Cell-cell Adhesion Cell-cell Adhesion Mediator Activity	Transcription Cis-regulatory Region Binding RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Zinc Ion Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Positive Regulation Of Immune System Process Apoptotic Process Inflammatory Response Cell Adhesion Integrin-mediated Signaling Pathway Positive Regulation Of Cell Population Proliferation Cell Migration Positive Regulation Of Cell-cell Adhesion Regulation Of Type II Interferon Production Regulation Of Interleukin-10 Production Regulation Of Interleukin-12 Production Regulation Of Interleukin-6 Production Regulation Of Tumor Necrosis Factor Production Heterotypic Cell-cell Adhesion Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Inflammatory Response Negative Regulation Of Phagocytosis Positive Regulation Of Phagocytosis Positive Regulation Of T Cell Activation Positive Regulation Of Stress Fiber Assembly Regulation Of Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Type II Interferon Cellular Response To Interleukin-1 Cellular Response To Interleukin-12 Cell-cell Adhesion ATP Export Positive Regulation Of Monocyte Extravasation	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Cytokine Production Regulation Of Immune System Process Negative Regulation Of Gene Expression Positive Regulation Of Interferon-beta Production Positive Regulation Of Interleukin-6 Production Positive Regulation Of Tumor Necrosis Factor Production Positive Regulation Of Glycolytic Process Negative Regulation Of DNA-templated Transcription Positive Regulation Of Lipid Biosynthetic Process Lipid Homeostasis Cellular Response To Glucose Stimulus
Pathways		Cell surface interactions at the vascular wall Integrin cell surface interactions Signal regulatory protein family interactions Signal regulatory protein family interactions Neutrophil degranulation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756 33263727 34002096) Body mass index ( 25673413) Refractive error ( 32231278) Regular attendance at a religious group ( 29970889)	Adult body size ( 32376654) Adventurousness ( 30643258) Fish- and plant-related diet ( 32066663) Gastric cancer ( 22037551 31383772) General risk tolerance (MTAG) ( 30643258) Haemorrhoidal disease ( 33888516) HDL cholesterol levels ( 32203549) HIV-1 viral setpoint ( 26039976) Mitochondrial DNA levels ( 25240745) Mucinous adenocarcinoma in colorectal cancer ( 29942513) Oily fish consumption ( 32066663) Platelet count ( 32888494) Plateletcrit ( 32888494) Pork consumption ( 32066663) Postoperative atrial fibrillation after cardiac surgery ( 30678657) Seasonality and depression ( 30217971) Serum alkaline phosphatase levels ( 33547301) Smoking initiation ( 33082346) Smoking status (ever vs never smokers) ( 30643258) Systolic blood pressure ( 30224653) Type 2 diabetes ( 26818947 32499647) Urate levels in obese individuals ( 25811787) Youthful appearance (self-reported) ( 32339537)
Interacting Genes		25 interacting genes: BNIP3 EPB42 FAS GAP43 GNAI1 IGF2BP2 IGSF8 ITGAV MAP3K10 MTIF3 MUC1 P2RY2 PLA1A PTK2 PVR RHAG SIRPA SRC SYNE4 TAGLN3 TFEB THBS1 TMEM167B UBQLN1 ZBTB20	5 interacting genes: CD47 CDK2 NR3C1 PPARG TMEM132D
Entrez ID		961	26137
HPRD ID		03017	05822
Ensembl ID		ENSG00000196776	ENSG00000181722
Uniprot IDs		A0A0A1TSG4 Q08722	B2RCW4 Q9HC78
PDB IDs		2JJS 2JJT 2VSC 4CMM 4KJY 5IWL 5TZ2 5TZT 5TZU 7MYZ 7WN8 7XJF 7YGG 8RP8
Enriched GO Terms of Interacting Partners?		Response To Mechanical Stimulus Regulation Of Apoptotic Signaling Pathway Cellular Response To Stress Signaling Receptor Activity Ankyrin-1 Complex Integrin Binding Signal Complex Assembly Regulation Of Apoptotic Process Positive Regulation Of Reactive Oxygen Species Metabolic Process Positive Regulation Of Catabolic Process Cellular Response To Hydrogen Peroxide Positive Regulation Of Phosphate Metabolic Process Regulation Of Focal Adhesion Assembly Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Programmed Cell Death Negative Regulation Of Apoptotic Process Regulation Of Cell-substrate Junction Organization Regulation Of Proteolysis Negative Regulation Of Programmed Cell Death Positive Regulation Of Fibroblast Migration Positive Regulation Of Metabolic Process Response To Hyperoxia Response To Hydrogen Peroxide Filopodium Membrane Negative Regulation Of Transport Transforming Growth Factor Beta Binding Fibroblast Growth Factor Binding Negative Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Integrin-mediated Signaling Pathway Positive Regulation Of Phosphorylation Fc-gamma Receptor Signaling Pathway Involved In Phagocytosis Positive Regulation Of Macrophage Chemotaxis Negative Regulation Of Anoikis Negative Regulation Of Focal Adhesion Assembly Positive Regulation Of Glycolytic Process Cellular Response To Reactive Oxygen Species Cell Motility Fc Receptor Mediated Stimulatory Signaling Pathway Cellular Response To Chemical Stress Multicellular Organismal-level Iron Ion Homeostasis Symbiont Entry Into Host Cell Protein Autophosphorylation Positive Regulation Of Macrophage Migration Regulation Of Anoikis Autophagy Fibronectin Binding Regulation Of Cell Adhesion Extracellular Matrix Binding Regulation Of Cell-matrix Adhesion	Cellular Response To Interleukin-12 Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex Cyclin E2-CDK2 Complex Positive Regulation Of DNA-templated DNA Replication Initiation Regulation Of MiRNA Transcription Nuclear Receptor-mediated Signaling Pathway Nuclear Glucocorticoid Receptor Activity Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Metabolic Process Positive Regulation Of MiRNA Transcription Nuclear Receptor Activity Negative Regulation Of Connective Tissue Replacement Involved In Inflammatory Response Wound Healing Positive Regulation Of Adiponectin Secretion Positive Regulation Of Chromatin Organization Cyclin-dependent Protein Kinase Activity Cyclin A2-CDK2 Complex Cyclin E1-CDK2 Complex Hormone-mediated Signaling Pathway Myeloid Leukocyte Differentiation Protein Binding Involved In Heterotypic Cell-cell Adhesion Positive Regulation Of Monocyte Extravasation ATP Export Response To Interleukin-12 Thrombospondin Receptor Activity X Chromosome Negative Regulation Of Transcription By RNA Polymerase II Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Cellular Response To Oxygen-containing Compound Histone Kinase Activity Nuclear Receptor-mediated Glucocorticoid Signaling Pathway Nuclear Receptor-mediated Corticosteroid Signaling Pathway Steroid Hormone Binding Intracellular Receptor Signaling Pathway Positive Regulation Of Lipoprotein Transport Arachidonate Binding Negative Regulation Of Mitochondrial Fission Prostaglandin Receptor Activity DNA Binding Domain Binding Fibrinogen Binding Protection From Non-homologous End Joining At Telomere Response To Cortisol Myeloid Cell Differentiation Negative Regulation Of Type II Interferon-mediated Signaling Pathway LBD Domain Binding Mammary Gland Duct Morphogenesis Microglia Differentiation DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific Regulation Of Heterochromatin Formation
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