P2RY2 and ITGB5

Number of citations of the paper that reports this interaction (PubMedID 11331301)
53

Data Source:
HPRD (in vitro, in vivo)

		P2RY2	ITGB5
Description		purinergic receptor P2Y2	integrin subunit beta 5
Image		No pdb structure
GO Annotations	Cellular Component	Plasma Membrane Membrane	Plasma Membrane Focal Adhesion Integrin Complex Cell Surface Membrane Integrin Alphav-beta5 Complex Receptor Complex Phagocytic Vesicle Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Activity Protein Binding A1 Adenosine Receptor Binding Signaling Receptor Activity G Protein-coupled Purinergic Nucleotide Receptor Activity G Protein-coupled UTP Receptor Activity	Virus Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Metal Ion Binding
	Biological Process	Intracellular Monoatomic Ion Homeostasis Signal Transduction G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway G Protein-coupled Purinergic Nucleotide Receptor Signaling Pathway Positive Regulation Of Mucus Secretion Cellular Response To ATP Blood Vessel Diameter Maintenance	Formation Of Primary Germ Layer Cell Adhesion Cell-matrix Adhesion Transforming Growth Factor Beta Receptor Signaling Pathway Integrin-mediated Signaling Pathway Cell Migration Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Epidermal Cells Endodermal Cell Differentiation Stress Fiber Assembly Symbiont Entry Into Host Cell Epithelial Cell-cell Adhesion Cell-cell Adhesion
Pathways		G alpha (q) signalling events P2Y receptors Surfactant metabolism High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells High laminar flow shear stress activates signaling by PIEZO1 and PECAM1:CDH5:KDR in endothelial cells	Cross-presentation of particulate exogenous antigens (phagosomes) Molecules associated with elastic fibres Integrin cell surface interactions Integrin cell surface interactions TGF-beta receptor signaling activates SMADs Syndecan interactions Syndecan interactions ECM proteoglycans Smooth Muscle Contraction
Drugs		Promethazine Suramin Denufosol INS 316
Diseases
GWAS		Alanine aminotransferase levels ( 34315874) Aspartate aminotransferase levels ( 34315874) Basophil count ( 32888494) Basophil percentage of granulocytes ( 27863252) Basophil percentage of white cells ( 27863252 32888494) Body mass index in asthmatics ( 23517042) Dentures ( 31235808) Glucose homeostasis traits ( 25524916) Insomnia (caffeine-induced) ( 22754043) Monocyte count ( 32888494) Monocyte percentage of white cells ( 32888494) Number of decayed, missing and filled tooth surfaces or use of dentures ( 31235808) Platelet distribution width ( 32888494) Systemic lupus erythematosus ( 26663301) White blood cell count (basophil) ( 27863252)	Airway hyperresponsiveness ( 23984888) Carpal tunnel syndrome ( 30833571) Coronary artery disease ( 28714974) Coronary artery disease (myocardial infarction, percutaneous transluminal coronary angioplasty, coronary artery bypass grafting, angina or chromic ischemic heart disease) ( 28714975) Diastolic blood pressure ( 27841878) Heel bone mineral density ( 30598549) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular hemoglobin concentration ( 32888494) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878 30578418)
Interacting Genes		7 interacting genes: APP CD47 ITGAV ITGB3 ITGB5 KDR SRC	58 interacting genes: ANXA5 APPBP2 CCN1 CYSRT1 DAB1 DAB2 DOK1 EFEMP2 EHMT2 EPS8 EWSR1 FDFT1 FHL2 FHL3 FLNA GAPDH GOLGA2 GON4L ITGA5 ITGAV ITGB3BP KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP3-2 KRTAP5-7 LTBP1 LTBP3 MTDH MTUS2 MYBPC2 MYO10 NBPF19 NOTCH2NLA NUMB P2RY2 PAK4 PALLD PPARD PTK2 RACK1 SNTA1 SPP1 SRSF9 STAB2 TAF1 TLN1 TNS2 TRIM55 TRIM63 TTN ZBTB17 ZNF655
Entrez ID		5029	3693
HPRD ID		02499	00949
Ensembl ID		ENSG00000175591	ENSG00000082781
Uniprot IDs		P41231	L7RT22 P18084
PDB IDs			7S46 7S47 7S48
Enriched GO Terms of Interacting Partners?		Integrin Binding Integrin-mediated Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of Cell Motility Positive Regulation Of Locomotion Cell Surface Wound Healing, Spreading Of Epidermal Cells Regulation Of Endocytosis Symbiont Entry Into Host Cell Cell Adhesion Cell Migration Integrin Alphav-beta3 Complex Integrin Alphav-beta5 Complex Integrin Complex Cell Adhesion Mediated By Integrin Wound Healing, Spreading Of Cells Regulation Of Cell Migration Cell-substrate Adhesion Biological Process Involved In Interaction With Host Cell Surface Receptor Signaling Pathway Regulation Of Cell Motility Heterotypic Cell-cell Adhesion Cell Motility Regulation Of Locomotion Positive Regulation Of Cell Adhesion Alphav-beta3 Integrin-PKCalpha Complex Alphav-beta3 Integrin-HMGB1 Complex Positive Regulation Of ERK1 And ERK2 Cascade Receptor Complex Regulation Of Vesicle-mediated Transport Substrate Adhesion-dependent Cell Spreading Alphav-beta3 Integrin-IGF-1-IGF1R Complex Apolipoprotein A-I-mediated Signaling Pathway C-X3-C Chemokine Binding Coreceptor Activity Negative Regulation Of Lipoprotein Metabolic Process Neuregulin Binding Cellular Response To Growth Factor Stimulus Regulation Of ERK1 And ERK2 Cascade Fibrinogen Binding Angiogenesis Response To Interleukin-1 Response To Growth Factor Virus Receptor Activity Signaling Receptor Activator Activity Regulation Of Cell Adhesion Anatomical Structure Formation Involved In Morphogenesis External Side Of Plasma Membrane Positive Regulation Of Mononuclear Cell Migration Ruffle Membrane	Keratin Filament Intermediate Filament Focal Adhesion Integrin-mediated Signaling Pathway Negative Regulation Of Apoptotic Process Cell Adhesion Actin Binding Z Disc Negative Regulation Of Programmed Cell Death Anchoring Junction Regulation Of Cell-substrate Adhesion Integrin Binding Cytoskeleton Organization Structural Molecule Activity Transforming Growth Factor Beta Binding Structural Constituent Of Skin Epidermis Positive Regulation Of Cell-substrate Adhesion M Band Protein Binding Wound Healing, Spreading Of Cells Extracellular Matrix Binding Actin Cytoskeleton Organization Supramolecular Fiber Organization Detection Of Muscle Stretch Cell-cell Adhesion Anatomical Structure Morphogenesis Regulation Of Cell Adhesion Ruffle Membrane Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Actin Filament-based Process Growth Factor Binding Ruffle Perinuclear Region Of Cytoplasm Positive Regulation Of Cell Migration Tissue Development Positive Regulation Of Cell Motility Regulation Of Apoptotic Process Cell Migration Positive Regulation Of Locomotion Positive Regulation Of Osteoblast Proliferation Microfibril Positive Regulation Of Bone Resorption Calcium Ion Binding Transcription Coregulator Activity Actin Crosslink Formation Cytoskeleton Regulation Of Programmed Cell Death Regulation Of Multicellular Organismal Process Regulation Of Substrate Adhesion-dependent Cell Spreading Positive Regulation Of Proteolysis Involved In Protein Catabolic Process
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