NRTN and GFRA2

Number of citations of the paper that reports this interaction (PubMedID 9407096)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vivo)

		NRTN	GFRA2
Description		neurturin	GDNF family receptor alpha 2
Image
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Receptor Complex Side Of Membrane
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Heparan Sulfate Binding	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity Heparan Sulfate Binding
	Biological Process	MAPK Cascade Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Nerve Development Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) N-glycan levels ( 21203500 21908519 31163085)	Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)
Interacting Genes		4 interacting genes: GFRA1 GFRA2 NFIX RET	3 interacting genes: GDNF NRTN PPP3CC
Entrez ID		4902	2675
HPRD ID		03604	11801
Ensembl ID		ENSG00000171119	ENSG00000168546
Uniprot IDs		Q99748	O00451
PDB IDs		5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R	5MR4 5MR5 6GL7 6Q2O 6Q2R
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Receptor Complex Extrinsic Component Of Membrane Plasma Membrane Protein Complex Signaling Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Side Of Membrane Posterior Midgut Development Kidney Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development System Development Neurotrophin Receptor Activity Ureter Maturation GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Heparan Sulfate Binding Lymphocyte Migration Into Lymphoid Organs External Side Of Plasma Membrane Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Differentiation Positive Regulation Of Cell Size Enteric Nervous System Development Axon Neuron Cell-cell Adhesion Response To Pain Neuron Projection Development Positive Regulation Of Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Embryonic Epithelial Tube Formation Neurotrophin Signaling Pathway Neuron Maturation Epithelial Tube Formation Membrane Protein Proteolysis Regulation Of Kidney Development Metanephros Development	Glial Cell-derived Neurotrophic Factor Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neural Crest Cell Migration Receptor Tyrosine Kinase Binding Mesenchymal Cell Migration Ameboidal-type Cell Migration Growth Factor Activity Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Formation Autonomic Nervous System Development Ureteric Bud Formation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Ureteric Bud Formation Dorsal Spinal Cord Development Positive Regulation Of Dopamine Secretion Chemoattraction Of Axon Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Calcineurin Complex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Receptor Binding Postsynaptic Membrane Organization Positive Regulation Of Epithelial Tube Formation Heparan Sulfate Binding Protein Serine/threonine Phosphatase Complex Positive Regulation Of Calcium Ion Import Across Plasma Membrane Peristalsis Positive Regulation Of Catecholamine Secretion Enteric Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nephron Tubule Formation Neuron Projection Development Commissural Neuron Axon Guidance Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal To Epithelial Transition Sympathetic Nervous System Development Nervous System Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade
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