NRTN and GFRA1

Number of citations of the paper that reports this interaction (PubMedID 9407096)
0

Data Source:
BioGRID (pull down, pull down)
HPRD (in vitro, in vivo)

		NRTN	GFRA1
Description		neurturin	GDNF family receptor alpha 1
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GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Extracellular Space Endosome Multivesicular Body Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Axon Neuronal Cell Body Receptor Complex Extracellular Exosome Side Of Membrane Plasma Membrane Protein Complex
	Molecular Function	Signaling Receptor Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Heparan Sulfate Binding	Neurotrophin Receptor Activity Signaling Receptor Binding Integrin Binding Protein Binding Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity
	Biological Process	MAPK Cascade Neural Crest Cell Migration Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Nerve Development Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT	Kidney Development Cell Surface Receptor Signaling Pathway Nervous System Development Male Gonad Development Cell Migration Neuron Differentiation Neuron Projection Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neurotrophin Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud
Drugs
Diseases
GWAS		Advanced age-related macular degeneration ( 26691988) Chronotype ( 30696823) N-glycan levels ( 21203500 21908519 31163085)	Blood protein levels ( 30072576) Delirium ( 29631748) Epilepsy and lamotrigine-induced maculopapular eruptions ( 26220383) Malaria ( 31844061) Migraine without aura ( 28952330) Response to anti-TNF therapy in rheumatoid arthritis ( 26776603)
Interacting Genes		4 interacting genes: GFRA1 GFRA2 NFIX RET	5 interacting genes: GDNF NCAM1 NRTN RET SOCS3
Entrez ID		4902	2674
HPRD ID		03604	03291
Ensembl ID		ENSG00000171119	ENSG00000151892
Uniprot IDs		Q99748	B7Z856 P56159
PDB IDs		5MR4 5MR5 5MR9 5NMZ 6GL7 6Q2O 6Q2R	6Q2N
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Receptor Complex Extrinsic Component Of Membrane Plasma Membrane Protein Complex Signaling Receptor Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Side Of Membrane Posterior Midgut Development Kidney Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development System Development Neurotrophin Receptor Activity Ureter Maturation GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Heparan Sulfate Binding Lymphocyte Migration Into Lymphoid Organs External Side Of Plasma Membrane Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Neuron Differentiation Positive Regulation Of Cell Size Enteric Nervous System Development Axon Neuron Cell-cell Adhesion Response To Pain Neuron Projection Development Positive Regulation Of Cell Adhesion Mediated By Integrin Cell Surface Receptor Signaling Pathway Embryonic Epithelial Tube Formation Neurotrophin Signaling Pathway Neuron Maturation Epithelial Tube Formation Membrane Protein Proteolysis Regulation Of Kidney Development Metanephros Development	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Binding Neural Crest Cell Migration Regulation Of Semaphorin-plexin Signaling Pathway Mesenchymal Cell Migration Neuron Projection Development Ameboidal-type Cell Migration Enteric Nervous System Development Commissural Neuron Axon Guidance Embryonic Epithelial Tube Formation Neuron Projection Guidance Axon Guidance Plasma Membrane Bounded Cell Projection Organization Epithelial Tube Formation Metanephros Development Regulation Of Kidney Development Ureteric Bud Development Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Mesonephric Epithelium Development Mesonephric Tubule Development Cell Projection Organization Receptor Tyrosine Kinase Binding Tissue Morphogenesis Kidney Epithelium Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Cell Surface Receptor Signaling Pathway Via STAT Nervous System Development Enzyme-linked Receptor Protein Signaling Pathway Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Tube Formation Posterior Midgut Development Morphogenesis Of A Branching Structure Regulation Of Extrinsic Apoptotic Signaling Pathway Growth Factor Activity Morphogenesis Of A Branching Epithelium Cell Surface Receptor Signaling Pathway Chemoattraction Of Axon Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Kidney Development Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Ureter Maturation Autonomic Nervous System Development Ureteric Bud Formation Cell Migration Dorsal Spinal Cord Development GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development
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