GFRA2 and PPP3CC

		GFRA2	PPP3CC
Description		GDNF family receptor alpha 2	protein phosphatase 3 catalytic subunit gamma
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Receptor Complex Side Of Membrane	Cytoplasm Mitochondrion Cytosol Calcineurin Complex Protein Serine/threonine Phosphatase Complex Presynapse Glutamatergic Synapse
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity Heparan Sulfate Binding	Phosphoprotein Phosphatase Activity Protein Serine/threonine Phosphatase Activity Calcium-dependent Protein Serine/threonine Phosphatase Activity Protein Binding Calmodulin Binding Hydrolase Activity Calmodulin-dependent Protein Phosphatase Activity Metal Ion Binding
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	Protein Dephosphorylation Calcineurin-NFAT Signaling Cascade Positive Regulation Of Calcineurin-NFAT Signaling Cascade Calcineurin-mediated Signaling Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Synaptic Vesicle Endocytosis Positive Regulation Of Calcium Ion Import Across Plasma Membrane Negative Regulation Of Calcium Ion Import Across Plasma Membrane
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	Activation of BAD and translocation to mitochondria DARPP-32 events
Drugs
Diseases
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)	General risk tolerance (MTAG) ( 30643258) HIV-1 viral setpoint ( 20205591) Verbal declarative memory ( 25648963)
Interacting Genes		3 interacting genes: GDNF NRTN PPP3CC	18 interacting genes: AMPH APP BCL2 BMPR1B CABIN1 CSNK2B ENTPD4 GFRA2 HAX1 ITPKC LEPROTL1 PPP3R1 SDC2 SLC18A1 SORBS3 TGFBR1 THAP7 UNC119
Entrez ID		2675	5533
HPRD ID		11801	00236
Ensembl ID		ENSG00000168546	ENSG00000120910
Uniprot IDs		O00451	P48454
PDB IDs		5MR4 5MR5 6GL7 6Q2O 6Q2R	7U0T
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neural Crest Cell Migration Receptor Tyrosine Kinase Binding Mesenchymal Cell Migration Ameboidal-type Cell Migration Growth Factor Activity Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Formation Autonomic Nervous System Development Ureteric Bud Formation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Ureteric Bud Formation Dorsal Spinal Cord Development Positive Regulation Of Dopamine Secretion Chemoattraction Of Axon Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Calcineurin Complex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Receptor Binding Postsynaptic Membrane Organization Positive Regulation Of Epithelial Tube Formation Heparan Sulfate Binding Protein Serine/threonine Phosphatase Complex Positive Regulation Of Calcium Ion Import Across Plasma Membrane Peristalsis Positive Regulation Of Catecholamine Secretion Enteric Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nephron Tubule Formation Neuron Projection Development Commissural Neuron Axon Guidance Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal To Epithelial Transition Sympathetic Nervous System Development Nervous System Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade	Regulation Of Extrinsic Apoptotic Signaling Pathway Heparan Sulfate Binding Transforming Growth Factor Beta Receptor Activity, Type I Receptor Complex Transmembrane Receptor Protein Serine/threonine Kinase Activity Cytoplasmic Vesicle Synapse Acetylcholine Receptor Activator Activity Negative Regulation Of Cell Population Proliferation Amyloid-beta Complex Regulation Of Cellular Component Organization PTB Domain Binding Cell Projection Morphogenesis Growth Cone Lamellipodium Positive Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Apoptotic Process Regulation Of Calcium Ion Transmembrane Transport Collateral Sprouting In Absence Of Injury Regulation Of Protein Import System Development Positive Regulation Of Programmed Cell Death Regulation Of Response To Calcium Ion Positive Regulation Of Cell Communication Positive Regulation Of Calcium-mediated Signaling Regulation Of Signal Transduction Regulation Of Multicellular Organism Growth Amylin Binding Neuron Projection Morphogenesis Positive Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Signaling Anatomical Structure Morphogenesis Endosome To Plasma Membrane Transport Vesicle Neuron Maturation Regulation Of Supramolecular Fiber Organization Positive Regulation Of Toll Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Cellular Response To Growth Factor Stimulus Positive Regulation Of Endothelin Production Positive Regulation Of Apoptotic Signaling Pathway Growth Cone Filopodium Regulation Of Receptor-mediated Endocytosis Positive Regulation Of Intracellular Signal Transduction Cell Surface Receptor Signaling Pathway Regulation Of Calcium Ion Transport Lipoprotein Particle Positive Regulation Of Cell Differentiation Regulation Of Receptor Internalization Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Signal Transduction Regulation Of Apoptotic Signaling Pathway
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