GFRA2 and GDNF

Number of citations of the paper that reports this interaction (PubMedID 9407096)
0

Data Source:
HPRD (in vitro)

		GFRA2	GDNF
Description		GDNF family receptor alpha 2	glial cell derived neurotrophic factor
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane Extrinsic Component Of Membrane Receptor Complex Side Of Membrane	Extracellular Region Extracellular Space Golgi Apparatus
	Molecular Function	Glial Cell-derived Neurotrophic Factor Receptor Activity Signaling Receptor Activity Heparan Sulfate Binding	Signaling Receptor Binding Protein Binding Growth Factor Activity Glial Cell-derived Neurotrophic Factor Receptor Binding Receptor Tyrosine Kinase Binding Protein Homodimerization Activity Chemoattractant Activity Involved In Axon Guidance
	Biological Process	Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nervous System Development Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway	Metanephros Development Ureteric Bud Development Branching Involved In Ureteric Bud Morphogenesis Neural Crest Cell Migration Organ Induction Postsynaptic Membrane Organization Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Signal Transduction Nervous System Development Peripheral Nervous System Development Positive Regulation Of Cell Population Proliferation Adult Locomotory Behavior Tissue Development Regulation Of Gene Expression Dorsal Spinal Cord Development Postganglionic Parasympathetic Fiber Development Neuron Differentiation Peristalsis Neuron Projection Development Positive Regulation Of Dopamine Secretion Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Negative Regulation Of Apoptotic Process Negative Regulation Of Neuron Apoptotic Process Regulation Of Cell Differentiation Positive Regulation Of Cell Differentiation Positive Regulation Of Transcription By RNA Polymerase II MRNA Stabilization Enteric Nervous System Development Sympathetic Nervous System Development Animal Organ Development Embryonic Organ Development Regulation Of Dopamine Uptake Involved In Synaptic Transmission Ureteric Bud Formation Regulation Of Morphogenesis Of A Branching Structure Chemoattraction Of Axon Commissural Neuron Axon Guidance Positive Regulation Of Ureteric Bud Formation Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Regulation Of Stem Cell Differentiation Negative Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Regulation Of Semaphorin-plexin Signaling Pathway
Pathways		NCAM1 interactions RAF/MAP kinase cascade RET signaling	NCAM1 interactions RAF/MAP kinase cascade RET signaling Formation of the ureteric bud
Drugs			Chondroitin sulfate
Diseases			Congenital central hypoventilation syndrome (CCHS) Hirschsprung disease (HD)
GWAS		Blood protein levels ( 30072576) Diisocyanate-induced asthma ( 25918132) Frontotemporal dementia ( 29724592) Frontotemporal dementia with GRN mutation ( 29724592) Migraine with aura ( 23793025) Neuropathic pain in type 2 diabetes ( 24974787) Nicotine dependence symptom count ( 25555482) Pelvic organ prolapse (moderate/severe) ( 26545240) Response to lithium treatment in bipolar disorder (continuous phenotype) ( 26806518) Trunk fat mass ( 28552196) Verbal declarative memory ( 25648963)	Asthma ( 29273806) Gut microbiota (bacterial taxa, hurdle binary method) ( 32572223) Major depressive disorder ( 20125088)
Interacting Genes		3 interacting genes: GDNF NRTN PPP3CC	8 interacting genes: AGTRAP GFRA1 GFRA2 MUC1 NCAM1 RET SCAMP5 SYP
Entrez ID		2675	2668
HPRD ID		11801	02906
Ensembl ID		ENSG00000168546	ENSG00000168621
Uniprot IDs		O00451	A0A0S2Z3T2 A0A0S2Z3V2 P39905
PDB IDs		5MR4 5MR5 6GL7 6Q2O 6Q2R	2V5E 3FUB 4UX8 6Q2N
Enriched GO Terms of Interacting Partners?		Glial Cell-derived Neurotrophic Factor Receptor Binding Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Neural Crest Cell Migration Receptor Tyrosine Kinase Binding Mesenchymal Cell Migration Ameboidal-type Cell Migration Growth Factor Activity Chemoattractant Activity Involved In Axon Guidance Postganglionic Parasympathetic Fiber Development Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Mesonephric Tubule Formation Autonomic Nervous System Development Ureteric Bud Formation Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Ureteric Bud Formation Dorsal Spinal Cord Development Positive Regulation Of Dopamine Secretion Chemoattraction Of Axon Regulation Of Semaphorin-plexin Signaling Pathway Positive Regulation Of Mesenchymal To Epithelial Transition Involved In Metanephros Morphogenesis Positive Regulation Of Synaptic Vesicle Endocytosis Negative Regulation Of Calcium Ion Import Across Plasma Membrane Positive Regulation Of Synaptic Vesicle Recycling Calcium-dependent Protein Serine/threonine Phosphatase Activity Calmodulin-dependent Protein Phosphatase Activity Calcineurin Complex Regulation Of Dopamine Uptake Involved In Synaptic Transmission Signaling Receptor Binding Postsynaptic Membrane Organization Positive Regulation Of Epithelial Tube Formation Heparan Sulfate Binding Protein Serine/threonine Phosphatase Complex Positive Regulation Of Calcium Ion Import Across Plasma Membrane Peristalsis Positive Regulation Of Catecholamine Secretion Enteric Nervous System Development Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Nephron Tubule Formation Neuron Projection Development Commissural Neuron Axon Guidance Negative Regulation Of Calcium Ion Import Regulation Of Calcium Ion Import Across Plasma Membrane Regulation Of Epithelial Cell Differentiation Involved In Kidney Development Mesenchymal To Epithelial Transition Sympathetic Nervous System Development Nervous System Development Positive Regulation Of Branching Involved In Ureteric Bud Morphogenesis Positive Regulation Of Calcineurin-NFAT Signaling Cascade Regulation Of Neurotransmitter Uptake Calcineurin-NFAT Signaling Cascade	Glial Cell-derived Neurotrophic Factor Receptor Signaling Pathway Glial Cell-derived Neurotrophic Factor Receptor Activity Side Of Membrane Plasma Membrane Protein Complex Extrinsic Component Of Membrane Receptor Complex Signaling Receptor Activity Regulation Of Cell Adhesion Mediated By Integrin External Side Of Plasma Membrane Plasma Membrane Membrane Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Neuron Projection Development Regulation Of Semaphorin-plexin Signaling Pathway Posterior Midgut Development Peyer's Patch Morphogenesis Positive Regulation Of Metanephric Glomerulus Development Regulation Of Opioid Receptor Signaling Pathway Nervous System Development Neurotrophin Receptor Activity Ureter Maturation Synaptic Vesicle Membrane Angiotensin Type II Receptor Activity GDF15-GFRAL Signaling Pathway Positive Regulation Of Glomerulus Development Kidney Development Enzyme-linked Receptor Protein Signaling Pathway Golgi Membrane Heparan Sulfate Binding Synaptic Vesicle Maturation Endosome Developmental Maturation Lymphocyte Migration Into Lymphoid Organs Axon Guidance Neuron Projection Guidance Positive Regulation Of Kidney Development Positive Regulation Of Extrinsic Apoptotic Signaling Pathway In Absence Of Ligand Negative Regulation Of Cell Adhesion Mediated By Integrin Regulation Of Synaptic Vesicle Priming Positive Regulation Of Cell Size Enteric Nervous System Development Cytoplasmic Vesicle Plasma Membrane Bounded Cell Projection Organization Negative Regulation Of Transcription By Competitive Promoter Binding Commissural Neuron Axon Guidance Regulation Of Short-term Neuronal Synaptic Plasticity
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