ATIC and CIP2A

		ATIC	CIP2A
Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	cellular inhibitor of PP2A
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body
	Molecular Function	Catalytic Activity IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Transferase Activity Hydrolase Activity Protein Homodimerization Activity Cadherin Binding	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration 'de Novo' AMP Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process 'de Novo' XMP Biosynthetic Process Cellular Response To Interleukin-7	DNA Damage Response Chromosome Organization Broken Chromosome Clustering
Pathways		Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)
Interacting Genes		11 interacting genes: CEBPA CIP2A CPS1 DES LINC01554 MAP3K7 MTNR1A OGT RBM11 SERPINB5 VWC2L	24 interacting genes: ATIC CDK1 CENPC CEP152 CEP192 CSNK2B CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3
Entrez ID		471	57650
HPRD ID		03434	11151
Ensembl ID		ENSG00000138363	ENSG00000163507
Uniprot IDs		P31939 V9HWH7	Q8TCG1
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0	5UFL
Enriched GO Terms of Interacting Partners?		Urea Metabolic Process Nitrogen Cycle Metabolic Process Urea Cycle	Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body
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