ATIC and SERPINB5

Number of citations of the paper that reports this interaction (PubMedID 16049007)
0

Data Source:
BioGRID (two hybrid)

		ATIC	SERPINB5
Description		5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase	serpin family B member 5
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GO Annotations	Cellular Component	Cytoplasm Cytosol Plasma Membrane Membrane Extracellular Exosome	Cornified Envelope Extracellular Region Extracellular Space Cytoplasm Sarcoplasm
	Molecular Function	Catalytic Activity IMP Cyclohydrolase Activity Phosphoribosylaminoimidazolecarboxamide Formyltransferase Activity Transferase Activity Hydrolase Activity Protein Homodimerization Activity Cadherin Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding
	Biological Process	Brainstem Development Nucleobase-containing Compound Metabolic Process Purine Nucleotide Biosynthetic Process GMP Biosynthetic Process 'de Novo' IMP Biosynthetic Process Cerebellum Development Cerebral Cortex Development Animal Organ Regeneration 'de Novo' AMP Biosynthetic Process Dihydrofolate Metabolic Process Tetrahydrofolate Biosynthetic Process 'de Novo' XMP Biosynthetic Process Cellular Response To Interleukin-7	Morphogenesis Of An Epithelium Extracellular Matrix Organization Regulation Of Epithelial Cell Proliferation Prostate Gland Morphogenesis
Pathways		Purine ribonucleoside monophosphate biosynthesis Signaling by ALK fusions and activated point mutants
Drugs		Tetrahydrofolic acid Methotrexate Pemetrexed AICA ribonucleotide Guanosine-5'-Monophosphate 5-monophosphate-9-beta-D-ribofuranosyl xanthine Acid yellow 54 free acid N-[4-([(2-Amino-4-oxo-1,4-dihydropyrido[3,2-d]pyrimidin-6-yl)methyl]{(2E)-3-[4-carbamoyl-1-(5-O-phosphono-beta-D-ribofuranosyl)-1H-imidazol-5-yl]-2-propenoyl}amino)benzoyl]-L-glutamic acid	S,S-(2-Hydroxyethyl)Thiocysteine
Diseases		AICA-ribosiduria; ATIC deficiency
GWAS		Airway imaging phenotypes ( 26030696) Metabolite levels ( 23823483)	Adverse response to chemotherapy in breast cancer (alopecia) (anti-microtubule) ( 24025145)
Interacting Genes		11 interacting genes: CEBPA CIP2A CPS1 DES LINC01554 MAP3K7 MTNR1A OGT RBM11 SERPINB5 VWC2L	26 interacting genes: AKT1 ATIC BASP1 BCAR3 CASP8 COL1A2 EEF1A1 ESR1 GOLGA4 GSTO1 HDAC1 HSP90AA1 HSP90AB1 HSPA5 KRAS LRRFIP1 MDH1 MT1H PALB2 PPIF PTBP1 SMAD4 TBP TKT UCHL5 XRCC3
Entrez ID		471	5268
HPRD ID		03434	01111
Ensembl ID		ENSG00000138363	ENSG00000206075
Uniprot IDs		P31939 V9HWH7	P36952
PDB IDs		1P4R 1PKX 1PL0 5UY8 5UZ0	1WZ9 1XQG 1XQJ 1XU8
Enriched GO Terms of Interacting Partners?		Urea Metabolic Process Nitrogen Cycle Metabolic Process Urea Cycle	Nitric-oxide Synthase Regulator Activity Protein-containing Complex Positive Regulation Of Nitric Oxide Biosynthetic Process Positive Regulation Of Nitric Oxide Metabolic Process Cytoplasm Regulation Of Nitric Oxide Biosynthetic Process Regulation Of Apoptotic Process Regulation Of Nitric Oxide Metabolic Process Regulation Of Programmed Cell Death Negative Regulation Of Programmed Cell Death Kinase Binding Regulation Of Protein Catabolic Process Cytosol Extracellular Exosome TFIIB-class Transcription Factor Binding Telomere Maintenance COP9 Signalosome ATP-dependent Protein Folding Chaperone Animal Organ Development Nucleobase-containing Compound Metabolic Process Negative Regulation Of Apoptotic Process Telomerase Holoenzyme Complex Assembly Telomere Organization Protein Homodimerization Activity Positive Regulation Of Signal Transduction Brainstem Development Transcription Corepressor Binding Dendritic Growth Cone TPR Domain Binding Regulation Of Intracellular Signal Transduction Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Protein Folding Chaperone Negative Regulation Of Intracellular Signal Transduction PERK-mediated Unfolded Protein Response Maintenance Of Protein Localization In Endoplasmic Reticulum Negative Regulation Of PERK-mediated Unfolded Protein Response Striated Muscle Cell Differentiation Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Developmental Process Negative Regulation Of Muscle Cell Differentiation Macromolecule Biosynthetic Process Positive Regulation Of Intracellular Signal Transduction Positive Regulation Of Striated Muscle Contraction Regulation Of Protein Ubiquitination Intracellular Signaling Cassette Positive Regulation Of Biosynthetic Process Regulation Of Growth Positive Regulation Of Cell Differentiation
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