CIP2A and SMC5

Number of citations of the paper that reports this interaction (PubMedID 25833693)
0

Data Source:
BioGRID (two hybrid)

		CIP2A	SMC5
Description		cellular inhibitor of PP2A	structural maintenance of chromosomes 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromosome Cytoplasm Centrosome Cytosol Plasma Membrane Ciliary Basal Body	Chromosome, Centromeric Region Chromosome, Telomeric Region Sex Chromosome Nucleus Nucleoplasm Chromosome Cytoplasm PML Body Nuclear Speck Cell Junction Smc5-Smc6 Complex Interchromatin Granule Site Of Double-strand Break
	Molecular Function	Protein Phosphatase Inhibitor Activity Protein Binding Protein Homodimerization Activity Cadherin Binding	Nucleotide Binding DNA Secondary Structure Binding Single-stranded DNA Binding Protein Binding ATP Binding ATP Hydrolysis Activity
	Biological Process	DNA Damage Response Chromosome Organization Broken Chromosome Clustering	Telomere Maintenance Via Recombination Double-strand Break Repair Via Homologous Recombination DNA Repair Double-strand Break Repair Double-strand Break Repair Via Nonhomologous End Joining DNA Recombination DNA Damage Response Chromosome Segregation Protein Sumoylation Stem Cell Population Maintenance Chromosome Condensation Regulation Of Telomere Maintenance Positive Regulation Of Maintenance Of Mitotic Sister Chromatid Cohesion Mitotic Cell Cycle Phase Transition Host-mediated Suppression Of Viral Genome Replication Chromosome Organization Cell Division Positive Regulation Of Chromosome Segregation Protein Localization To Chromosome, Centromeric Region Cellular Senescence Chromatin Looping
Pathways			SUMOylation of DNA damage response and repair proteins
Drugs
Diseases
GWAS			Age at first sexual intercourse ( 27089180)
Interacting Genes		24 interacting genes: ATIC CDK1 CENPC CEP152 CEP192 CSNK2B CSPP1 GOLGA4 LAMB2 MYC NDC80 NEK2 PIK3R1 PPP2R5C PSMA1 PSMA3 RBM5 RNF2 SMC5 STUB1 SYNCRIP TOPBP1 UBR5 WWC3	6 interacting genes: CIP2A DISC1 NSMCE2 SMN1 TK1 VHL
Entrez ID		57650	23137
HPRD ID		11151	10241
Ensembl ID		ENSG00000163507	ENSG00000198887
Uniprot IDs		Q8TCG1	Q8IY18
PDB IDs		5UFL
Enriched GO Terms of Interacting Partners?		Nucleoplasm Chromosome Organization Centrosome Chromosome Chromosome, Centromeric Region Centrosome Duplication Procentriole DNA Damage Response Cytosol Positive Regulation Of Chromosome Organization Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Chromosome Organization Positive Regulation Of Protein Import Into Nucleus Cytoplasm Microtubule Cytoskeleton Organization Involved In Mitosis Procentriole Replication Complex Chromosome Segregation Mitotic Cell Cycle Membraneless Organelle Assembly Proteasomal Protein Catabolic Process Regulation Of Cell Cycle Process Proteasome Core Complex, Alpha-subunit Complex Cell Cycle Phase Transition Regulation Of Protein Import Into Nucleus Positive Regulation Of Nucleocytoplasmic Transport Ubiquitin-dependent Protein Catabolic Process Modification-dependent Protein Catabolic Process Nuclear Body Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Catabolic Process Microtubule Organizing Center Organization Ubiquitin-ubiquitin Ligase Activity Kinetochore Organization Positive Regulation Of Intracellular Protein Transport Proteolysis Involved In Protein Catabolic Process Mitotic Spindle Organization Spindle Assembly Cell Division Positive Regulation Of Protein Localization To Nucleus Attachment Of Mitotic Spindle Microtubules To Kinetochore Proteasome Core Complex DNA Metabolic Process Protein Localization To Chromosome Intracellular Signal Transduction Regulation Of Attachment Of Spindle Microtubules To Kinetochore Positive Regulation Of Cell Cycle Process Peptidyl-threonine Phosphorylation Macromolecule Metabolic Process Regulation Of Cell Cycle PML Body
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