EMD and ACTG2

Number of citations of the paper that reports this interaction (PubMedID 12670476)
0

Data Source:
BioGRID (pull down)

		EMD	ACTG2
Description		emerin	actin gamma 2, smooth muscle
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GO Annotations	Cellular Component	Nucleus Nuclear Envelope Nuclear Inner Membrane Nuclear Outer Membrane Nucleoplasm Cytoplasm Endoplasmic Reticulum Spindle Cytosol Microtubule Membrane Spindle Pole Centrosome Nuclear Membrane Cortical Endoplasmic Reticulum TMEM240-body	Extracellular Space Cytoplasm Cytosol Cytoskeleton Actin Cytoskeleton Lamellipodium Filopodium Myosin Filament Cell Body Extracellular Exosome Cell Periphery Blood Microparticle
	Molecular Function	Actin Binding Protein Binding Cadherin Binding Beta-tubulin Binding	Nucleotide Binding ATP Binding Hydrolase Activity
	Biological Process	Muscle Contraction Muscle Organ Development Skeletal Muscle Cell Differentiation Positive Regulation Of Protein Export From Nucleus Negative Regulation Of Fibroblast Proliferation Regulation Of Canonical Wnt Signaling Pathway Cellular Response To Growth Factor Stimulus Nuclear Membrane Organization Negative Regulation Of Canonical Wnt Signaling Pathway Amyloid Fibril Formation	Positive Regulation Of Gene Expression Mesenchyme Migration
Pathways		Nuclear Envelope Breakdown Initiation of Nuclear Envelope (NE) Reformation Depolymerization of the Nuclear Lamina RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOG GTPase cycle RAC3 GTPase cycle Insertion of tail-anchored proteins into the endoplasmic reticulum membrane Insertion of tail-anchored proteins into the endoplasmic reticulum membrane	Smooth Muscle Contraction Regulation of CDH1 Function Formation of the dystrophin-glycoprotein complex (DGC) Formation of the dystrophin-glycoprotein complex (DGC)
Drugs
Diseases		Emery-Dreifuss muscular dystrophy
GWAS		Mean spheric corpuscular volume ( 32888494)	Parent of origin effect on receptive language ability (paternal) ( 32635940)
Interacting Genes		100 interacting genes: ABL1 ABT1 ACTB ACTG2 AEN AKAP8L ANK1 ANKS6 AQP6 AVPI1 BANF1 BCLAF1 BEND7 BYSL CATSPER1 CCDC33 CCNL2 CD33 CEP70 CERS4 CISD2 CLEC14A COMT COPS6 CPLX4 CREB3 CTNNBIP1 CXorf66 DPPA4 EFHC2 ERMAP FAM209A FATE1 GMCL1 GOLM2 GORAB GPR152 GRAMD2A HSF2BP INCA1 KASH5 KCNJ12 KCNJ18 KCNJ8 KCNN3 KIF9 KIR2DL3 LIME1 LMNA LMO7 LPL LUZP4 MAB21L3 MAPK6 MEOX1 MEOX2 MMGT1 MRPL45 MTERF4 MTNR1A NCAPH2 NF2 NPDC1 PAK5 PIMREG PSME1 REL RNASEH1 RNF123 SH3GL2 SH3GL3 SLC10A1 SLC35H1 SOWAHB SRC SSMEM1 STX1A SYNE1 TCF23 TMEM174 TMEM200A TMEM201 TMEM52B TMEM80 TMX2 TRAF3IP3 TRIM42 VAV1 WEE2-AS1 YTHDC1 ZFP1 ZFP57 ZFP64 ZNF165 ZNF232 ZNF329 ZNF341 ZNF398 ZNF549 ZNF774	4 interacting genes: EMD MLH1 NEB SHBG
Entrez ID		2010	72
HPRD ID		02309	00016
Ensembl ID		ENSG00000102119	ENSG00000163017
Uniprot IDs		P50402	P63267
PDB IDs		1JEI 2ODC 2ODG 6GHD 6RPR 7NDY	6JAT 8V2O 8V2Z 8V30
Enriched GO Terms of Interacting Partners?		Protein Binding Inward Rectifier Potassium Channel Activity Fc-gamma Receptor Signaling Pathway	Muscle Structure Development TMEM240-body Muscle Organ Development Meiotic Spindle Midzone Assembly Meiotic Metaphase Chromosome Alignment Chiasma Late Recombination Nodule Meiotic Metaphase I Homologous Chromosome Alignment Male Meiosis Chromosome Segregation MutLalpha Complex Cardiac Muscle Thin Filament Assembly Guanine/thymine Mispair Binding Homologous Chromosome Segregation Female Meiosis Chromosome Segregation Mismatch Repair Complex Negative Regulation Of Mitotic Recombination Somatic Muscle Development Androgen Binding Positive Regulation Of Isotype Switching To IgA Isotypes MutSalpha Complex Binding Regulation Of Mitotic Recombination Cortical Endoplasmic Reticulum Meiotic Telomere Clustering Chromosome Localization To Nuclear Envelope Involved In Homologous Chromosome Segregation Telomere Localization Mismatched DNA Binding Positive Regulation Of Isotype Switching To IgG Isotypes Actin Binding Spindle Midzone Assembly Somatic Hypermutation Of Immunoglobulin Genes Contractile Muscle Fiber Meiotic Chromosome Segregation Somatic Diversification Of Immune Receptors Via Somatic Mutation Spindle Pole Centrosome Regulation Of Isotype Switching To IgG Isotypes Resolution Of Meiotic Recombination Intermediates ATP-dependent DNA Damage Sensor Activity Nuclear-transcribed MRNA Poly(A) Tail Shortening Positive Regulation Of Protein Export From Nucleus Supramolecular Fiber Organization Amyloid Fibril Formation Isotype Switching Homologous Chromosome Pairing At Meiosis Positive Regulation Of Isotype Switching Mismatch Repair Somatic Diversification Of Immunoglobulins Involved In Immune Response Reciprocal Meiotic Recombination Synaptonemal Complex Somatic Recombination Of Immunoglobulin Genes Involved In Immune Response Steroid Binding
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