AOX1 and CTLA4

		AOX1	CTLA4
Description		aldehyde oxidase 1	cytotoxic T-lymphocyte associated protein 4
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton Nuclear Body Intercellular Bridge Extracellular Exosome	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion
	Molecular Function	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NAD Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding	Protein Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process	Adaptive Immune Response Immune System Process Immune Response DNA Damage Response Negative Regulation Of B Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway
Pathways		Vitamin B6 activation to pyridoxal phosphate	Co-stimulation by CD28 Co-inhibition by CTLA4 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		Cyclobenzaprine Eniluracil	Abatacept Ipilimumab Tremelimumab
Diseases		Xanthinuria	Graves' disease Allograft rejection Type I diabetes mellitus Hashimoto's thyroiditis
GWAS		Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)	Addison's disease ( 33574239) Alopecia areata ( 25608926 20596022) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 30572963 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691 27182965) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 24390342 30423114 30572963 23143596 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 19430480 30659077 30572963 25751624 21829393 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)
Interacting Genes		8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1	27 interacting genes: AOX1 AP1M1 AP2M1 ATP5MC3 BCS1L CD28 CD80 CD86 CDC26 CLK1 CTXN3 DCTD FYN GLP1R JAK2 LCK LYN MALL PIK3R1 PLCL1 PPP2R5A PTPN11 SKP1 STAT5A STAT5B TMEM218 TXK
Entrez ID		316	1493
HPRD ID		07537	00474
Ensembl ID		ENSG00000138356	ENSG00000163599
Uniprot IDs		Q06278	P16410
PDB IDs		4UHW 4UHX 5EPG 6Q6Q 7OPN 7ORC 8EMT	1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO 7DV4 7ELX 7SU0 7SU1 8GAB 8HIT 9DQ3
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Lipid Metabolic Process Response To Xenobiotic Stimulus Apolipoprotein A-I-mediated Signaling Pathway Sterol Metabolic Process Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Cholesterol Metabolic Process Sterol Homeostasis Sphingolipid Translocation Alcohol Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Cellular Response To Xenobiotic Stimulus Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cholesterol Homeostasis Protein Insertion Into Mitochondrial Inner Membrane From Matrix Helper T Cell Diapedesis Chordate Pharynx Development T Cell Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Cerebellar Neuron Development Antigen Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Protein Complex Involved In Cell Adhesion Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Kinase Activity Error-free Translesion Synthesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Lipid Homeostasis Parathyroid Gland Development Negative Regulation Of Regulatory T Cell Differentiation	T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Growth Hormone Receptor Signaling Pathway Leukocyte Activation T Cell Activation Lymphocyte Activation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Interleukin-2 Production Regulation Of Mononuclear Cell Proliferation Regulation Of Immune Response Positive Regulation Of Leukocyte Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Leukocyte Proliferation Phosphatidylinositol 3-kinase Binding Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell Activation Positive Regulation Of Immune Response Protein Tyrosine Kinase Activity Regulation Of Interleukin-2 Production Positive Regulation Of Cytokine Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Hemopoiesis Regulation Of Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Mononuclear Cell Differentiation Peptide Hormone Receptor Binding Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Proliferation Regulation Of Lymphocyte Differentiation
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