AOX1 and BCS1L

		AOX1	BCS1L
Description		aldehyde oxidase 1	BCS1 ubiquinol-cytochrome c reductase complex chaperone
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton Nuclear Body Intercellular Bridge Extracellular Exosome	Mitochondrion Mitochondrial Inner Membrane Membrane Respiratory Chain Complex III
	Molecular Function	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NAD Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding	Nucleotide Binding Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process	Mitochondrion Organization Protein Insertion Into Mitochondrial Inner Membrane From Matrix Mitochondrial Respiratory Chain Complex I Assembly Mitochondrial Cytochrome C Oxidase Assembly Mitochondrial Respiratory Chain Complex III Assembly
Pathways		Vitamin B6 activation to pyridoxal phosphate	Mitochondrial protein import Complex III assembly
Drugs		Cyclobenzaprine Eniluracil
Diseases		Xanthinuria	Bjornstad syndrome Mitochondrial respiratory chain deficiencies (MRCD), including: Mitochondrial complex I deficiency (MT-C1D); Complex II deficiency (MT-C2D); Complex III deficiency (MT-C3D); Complex IV deficiency (MT-C4D); Complex V deficiency (MT-ATPSD); Leigh syndrome (LS); Kearns-Sayre Syndrome (KSS); LCHD deficiency (LCHD); Leber Hereditary Optic Neuropathy (LHON); Myoclonic Epilepsy and Ragged-Red Fiber Disease (MERRF); NARP; MELAS; ACAD9 deficiency; HADH deficiency; HIBCH deficiency; GRACILE syndrome
GWAS		Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)	Male-pattern baldness ( 28196072)
Interacting Genes		8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1	14 interacting genes: AOX1 ARHGAP18 CD28 CLK1 CTLA4 DDX24 DNAJA1 MRPS12 MTDH ORC2 RP9 RPE SLC29A1 WDFY1
Entrez ID		316	617
HPRD ID		07537	04708
Ensembl ID		ENSG00000138356	ENSG00000074582
Uniprot IDs		Q06278	A0A024R445 A8JZZ8 Q9Y276
PDB IDs		4UHW 4UHX 5EPG 6Q6Q 7OPN 7ORC 8EMT
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Lipid Metabolic Process Response To Xenobiotic Stimulus Apolipoprotein A-I-mediated Signaling Pathway Sterol Metabolic Process Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Cholesterol Metabolic Process Sterol Homeostasis Sphingolipid Translocation Alcohol Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Cellular Response To Xenobiotic Stimulus Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cholesterol Homeostasis Protein Insertion Into Mitochondrial Inner Membrane From Matrix Helper T Cell Diapedesis Chordate Pharynx Development T Cell Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Cerebellar Neuron Development Antigen Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Protein Complex Involved In Cell Adhesion Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Kinase Activity Error-free Translesion Synthesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Lipid Homeostasis Parathyroid Gland Development Negative Regulation Of Regulatory T Cell Differentiation	Protein Complex Involved In Cell Adhesion
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