AOX1

Description		aldehyde oxidase 1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Microtubule Cytoskeleton Nuclear Body Intercellular Bridge Extracellular Exosome
	Molecular Function	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NAD Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding
	Biological Process	Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways		Vitamin B6 activation to pyridoxal phosphate
Drugs		Cyclobenzaprine Eniluracil
Diseases		Xanthinuria
GWAS		Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)
Novel Interacting Genes		8 novel interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1
Interacting Genes		8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1
Entrez ID		316
HPRD ID		07537
Ensembl ID		ENSG00000138356
Uniprot IDs		Q06278
PDB IDs		4UHW 4UHX 5EPG 6Q6Q 7OPN 7ORC 8EMT
Enriched GO Terms of Interacting Partners?		Response To Vitamin B3 Lipid Metabolic Process Response To Xenobiotic Stimulus Apolipoprotein A-I-mediated Signaling Pathway Sterol Metabolic Process Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Cholesterol Metabolic Process Sterol Homeostasis Sphingolipid Translocation Alcohol Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Cellular Response To Xenobiotic Stimulus Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cholesterol Homeostasis Protein Insertion Into Mitochondrial Inner Membrane From Matrix Helper T Cell Diapedesis Chordate Pharynx Development T Cell Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Cerebellar Neuron Development Antigen Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Protein Complex Involved In Cell Adhesion Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Kinase Activity Error-free Translesion Synthesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Lipid Homeostasis Parathyroid Gland Development Negative Regulation Of Regulatory T Cell Differentiation
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