CTLA4 and PLCL1

		CTLA4	PLCL1
Description		cytotoxic T-lymphocyte associated protein 4	phospholipase C like 1 (inactive)
Image			No pdb structure
GO Annotations	Cellular Component	Golgi Apparatus Plasma Membrane External Side Of Plasma Membrane Membrane Clathrin-coated Endocytic Vesicle Perinuclear Region Of Cytoplasm Protein Complex Involved In Cell Adhesion	Cytoplasm
	Molecular Function	Protein Binding	Phosphatidylinositol-4,5-bisphosphate Phospholipase C Activity Phospholipase C Activity Phosphoric Diester Hydrolase Activity
	Biological Process	Adaptive Immune Response Immune System Process Immune Response DNA Damage Response Negative Regulation Of B Cell Proliferation Regulation Of T Cell Proliferation Negative Regulation Of T Cell Proliferation Positive Regulation Of Apoptotic Process Negative Regulation Of Regulatory T Cell Differentiation T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Lipid Metabolic Process Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Regulation Of Synaptic Transmission, GABAergic Intracellular Signal Transduction Phosphatidylinositol Metabolic Process Phosphatidylinositol-mediated Signaling Release Of Sequestered Calcium Ion Into Cytosol Negative Regulation Of Cold-induced Thermogenesis
Pathways		Co-stimulation by CD28 Co-inhibition by CTLA4 RUNX1 and FOXP3 control the development of regulatory T lymphocytes (Tregs)
Drugs		Abatacept Ipilimumab Tremelimumab	Quinacrine
Diseases		Graves' disease Allograft rejection Type I diabetes mellitus Hashimoto's thyroiditis
GWAS		Addison's disease ( 33574239) Alopecia areata ( 25608926 20596022) Autoimmune thyroid disease ( 32581359) Autoimmune traits (pleiotropy) ( 30572963) Basal cell carcinoma ( 31174203 33549134) Celiac disease ( 22057235 30572963 20190752 25920553) Celiac disease and Rheumatoid arthritis ( 26546613) Graves' disease ( 21841780) Heel bone mineral density ( 30598549) Hypothyroidism ( 22493691 27182965) Inflammatory bowel disease ( 26192919) Keratinocyte cancer (MTAG) ( 31174203) Medication use (thyroid preparations) ( 31015401) Multiple sclerosis ( 24076602) Myasthenia gravis ( 25643325) Primary biliary cholangitis ( 28425483) Rheumatoid arthritis ( 24390342 30423114 30572963 23143596 19503088) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Subcutaneous adipose tissue ( 29178545) Systemic lupus erythematosus ( 33536424) Type 1 diabetes ( 19430480 30659077 30572963 25751624 21829393 18978792) Ulcerative colitis ( 26192919) Vitiligo ( 27723757)	A body shape index ( 34021172) Adult body size ( 32376654) Alcohol consumption ( 23743675) Allergic disease (asthma, hay fever or eczema) ( 29083406) Allergic rhinitis ( 30013184) Allergy ( 27182965) Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Appendicular lean mass ( 33097823) Asthma ( 31361310 32296059) Autism spectrum disorder or schizophrenia ( 28540026) Body fat distribution (arm fat ratio) ( 30664634) Body fat distribution (trunk fat ratio) ( 30664634) Brain cytoarchitecture ( 20308991) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Central retinal arteriolar equivalent ( 31597446) Chin dimples ( 27182965) Chronotype ( 30696823) Coronary artery disease ( 26708285) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Crohn's disease ( 28067908 21102463) Dermatomyositis ( 23983088) Educational attainment ( 23722424) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Hip bone size ( 18776929) Intracranial aneurysm ( 18997786) Low high density lipoprotein cholesterol levels ( 26879886) Menarche (age at onset) ( 21102462 27182965) Mood instability ( 31168069) Morning person ( 30696823) Morning vs. evening chronotype ( 26835600) Neutrophil count ( 21507922) Rheumatoid arthritis ( 30891314 32868391) Schizophrenia ( 25056061 29483656 30285260) Self-reported allergy ( 23817569) Serum alkaline phosphatase levels ( 33547301) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Sun-seeking behavior ( 32920024) Systemic lupus erythematosus ( 28714469 33536424) Total body bone mineral density ( 29304378) Ulcerative colitis ( 23128233) Urinary sodium excretion ( 31409800) Waist circumference adjusted for body mass index ( 34021172)
Interacting Genes		27 interacting genes: AOX1 AP1M1 AP2M1 ATP5MC3 BCS1L CD28 CD80 CD86 CDC26 CLK1 CTXN3 DCTD FYN GLP1R JAK2 LCK LYN MALL PIK3R1 PLCL1 PPP2R5A PTPN11 SKP1 STAT5A STAT5B TMEM218 TXK	1 interacting genes: CTLA4
Entrez ID		1493	5334
HPRD ID		00474	07041
Ensembl ID		ENSG00000163599	ENSG00000115896
Uniprot IDs		P16410	Q15111
PDB IDs		1AH1 1H6E 1I85 1I8L 2X44 3BX7 3OSK 5GGV 5TRU 5XJ3 6RP8 6RPJ 6RQM 6XY2 7CIO 7DV4 7ELX 7SU0 7SU1 8GAB 8HIT 9DQ3
Enriched GO Terms of Interacting Partners?		T Cell Costimulation Positive Regulation Of T Cell Activation Positive Regulation Of Leukocyte Cell-cell Adhesion Positive Regulation Of Lymphocyte Activation Positive Regulation Of Cell-cell Adhesion Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Leukocyte Cell-cell Adhesion Regulation Of T Cell Activation Positive Regulation Of Cell Activation Growth Hormone Receptor Signaling Pathway Leukocyte Activation T Cell Activation Lymphocyte Activation Cell Activation Positive Regulation Of Cell Adhesion Regulation Of Cell-cell Adhesion Regulation Of Lymphocyte Activation Positive Regulation Of Interleukin-2 Production Regulation Of Mononuclear Cell Proliferation Regulation Of Immune Response Positive Regulation Of Leukocyte Proliferation Growth Hormone Receptor Signaling Pathway Via JAK-STAT Regulation Of Leukocyte Proliferation Phosphatidylinositol 3-kinase Binding Regulation Of T Cell Proliferation Positive Regulation Of Immune System Process Positive Regulation Of T Cell Proliferation Regulation Of Cell Adhesion Regulation Of Cell Activation Positive Regulation Of Immune Response Protein Tyrosine Kinase Activity Regulation Of Interleukin-2 Production Positive Regulation Of Cytokine Production Interleukin-5-mediated Signaling Pathway Positive Regulation Of Lymphocyte Proliferation Positive Regulation Of Mononuclear Cell Proliferation T Cell Differentiation Regulation Of Hemopoiesis Regulation Of Cytokine Production Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Activated T Cell Proliferation Positive Regulation Of Gamma-delta T Cell Differentiation Regulation Of T Cell Differentiation Mononuclear Cell Differentiation Peptide Hormone Receptor Binding Positive Regulation Of Gamma-delta T Cell Activation Gamma-delta T Cell Differentiation Regulation Of Gamma-delta T Cell Differentiation Lymphocyte Proliferation Regulation Of Lymphocyte Differentiation	Protein Complex Involved In Cell Adhesion Negative Regulation Of Regulatory T Cell Differentiation Negative Regulation Of B Cell Proliferation Clathrin-coated Endocytic Vesicle Regulation Of Regulatory T Cell Differentiation Negative Regulation Of B Cell Activation Regulation Of B Cell Proliferation Negative Regulation Of Lymphocyte Differentiation B Cell Receptor Signaling Pathway Negative Regulation Of T Cell Differentiation Negative Regulation Of T Cell Proliferation Negative Regulation Of Leukocyte Proliferation Negative Regulation Of Lymphocyte Proliferation T Cell Receptor Signaling Pathway Negative Regulation Of Hemopoiesis Negative Regulation Of Mononuclear Cell Proliferation Regulation Of B Cell Activation Negative Regulation Of T Cell Activation Negative Regulation Of Leukocyte Cell-cell Adhesion Antigen Receptor-mediated Signaling Pathway Negative Regulation Of Lymphocyte Activation Regulation Of T Cell Proliferation Regulation Of T Cell Differentiation Negative Regulation Of Cell Activation Regulation Of Lymphocyte Differentiation Negative Regulation Of Cell-cell Adhesion Negative Regulation Of Leukocyte Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Regulation Of Mononuclear Cell Proliferation Immune Response-regulating Cell Surface Receptor Signaling Pathway Regulation Of Leukocyte Proliferation Negative Regulation Of Cell Development Adaptive Immune Response Negative Regulation Of Cell Adhesion Immune Response-activating Signaling Pathway External Side Of Plasma Membrane
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