GK and AOX1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		GK	AOX1
Description		glycerol kinase	aldehyde oxidase 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Membrane Extracellular Exosome	Cytoplasm Cytosol Microtubule Cytoskeleton Nuclear Body Intercellular Bridge Extracellular Exosome
	Molecular Function	Nucleotide Binding Glycerol Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Phosphotransferase Activity, Alcohol Group As Acceptor Metal Ion Binding	Aldehyde Oxidase Activity Iron Ion Binding Oxidoreductase Activity Identical Protein Binding Protein Homodimerization Activity Molybdopterin Cofactor Binding Metal Ion Binding Flavin Adenine Dinucleotide Binding NAD Binding Iron-sulfur Cluster Binding 2 Iron, 2 Sulfur Cluster Binding FAD Binding
	Biological Process	Carbohydrate Metabolic Process Glycerol Metabolic Process Glycerol-3-phosphate Metabolic Process Triglyceride Metabolic Process Triglyceride Biosynthetic Process Glycerol Catabolic Process Glycerol-3-phosphate Biosynthetic Process	Lipid Metabolic Process Xenobiotic Metabolic Process
Pathways		Triglyceride biosynthesis	Vitamin B6 activation to pyridoxal phosphate
Drugs			Cyclobenzaprine Eniluracil
Diseases		Glycerol kinase deficiency (GKD), including: Hyperglycerolemia; Chromosome Xp21 deletion syndrome; Adrenal hypoplasia, congenital (AHC); Duchenne muscular dystrophy (DMD)	Xanthinuria
GWAS		Cardiovascular risk factors (age interaction) ( 20838585)	Hip circumference adjusted for BMI ( 28552196) Intelligence ( 22449649) Late-onset Alzheimer's disease ( 27770636)
Interacting Genes		11 interacting genes: AOX1 APCS CLPTM1L CYP3A4 EIF4G1 FBXO28 GPD1 IPO13 NR4A1 OPLAH RXRA	8 interacting genes: ABCA1 BCS1L CRKL CTLA4 ERRFI1 GK RBL1 RCHY1
Entrez ID		2710	316
HPRD ID		08363	07537
Ensembl ID		ENSG00000198814	ENSG00000138356
Uniprot IDs		A0A8I5KXY7 B4DH54 P32189	Q06278
PDB IDs			4UHW 4UHX 5EPG 6Q6Q 7OPN 7ORC 8EMT
Enriched GO Terms of Interacting Partners?		Aldehyde Oxidase Activity Identical Protein Binding NAD Binding Negative Regulation By Host Of Viral Glycoprotein Metabolic Process Quinine 3-monooxygenase Activity Anandamide 8,9 Epoxidase Activity Vitamin D 24-hydroxylase Activity Anandamide 11,12 Epoxidase Activity 1,8-cineole 2-exo-monooxygenase Activity Anandamide 14,15 Epoxidase Activity Vitamin D3 25-hydroxylase Activity 1-alpha,25-dihydroxyvitamin D3 23-hydroxylase Activity Positive Regulation Of Eukaryotic Translation Initiation Factor 4F Complex Assembly Glycerol-3-phosphate Dehydrogenase (NAD+) Activity Glycerol-3-phosphate Dehydrogenase [NAD(P)+] Activity Glycerol-3-phosphate Catabolic Process Glycerol-3-phosphate Shuttle Nuclear Receptor Activity 5-oxoprolinase (ATP-hydrolyzing) Activity Vitamin D Biosynthetic Process Calcitriol Biosynthetic Process From Calciol Vitamin D Catabolic Process Alkaloid Catabolic Process Vitamin D Response Element Binding Positive Regulation Of Thyroid Hormone Receptor Signaling Pathway Molybdopterin Cofactor Binding Xenobiotic Metabolic Process Iron Ion Binding Negative Regulation Of Monocyte Differentiation Testosterone 6-beta-hydroxylase Activity Vitamin D3 Metabolic Process Monoterpenoid Metabolic Process Lipid Hydroxylation Caffeine Oxidase Activity Cap-dependent Translational Initiation Positive Regulation Of Translation In Response To Endoplasmic Reticulum Stress Glycerol-3-phosphate Metabolic Process Non-canonical Inflammasome Complex Assembly Double-stranded DNA Binding Import Into Nucleus Detection Of Lipopolysaccharide Cellular Response To Corticotropin-releasing Hormone Stimulus Protein Import Into Nucleus Positive Regulation Of Lipoprotein Transport Regulation Of Thyroid Hormone Receptor Signaling Pathway Positive Regulation Of Vitamin D Receptor Signaling Pathway DNA Binding Domain Binding Oxidoreductase Activity Estrogen 16-alpha-hydroxylase Activity Positive Regulation Of Translation In Response To Stress	Response To Vitamin B3 Lipid Metabolic Process Response To Xenobiotic Stimulus Apolipoprotein A-I-mediated Signaling Pathway Sterol Metabolic Process Floppase Activity Regulation Of High-density Lipoprotein Particle Assembly Cholesterol Metabolic Process Sterol Homeostasis Sphingolipid Translocation Alcohol Metabolic Process Positive Regulation Of High-density Lipoprotein Particle Assembly Cellular Response To Xenobiotic Stimulus Apolipoprotein A-I Receptor Activity Apolipoprotein A-I Binding Phosphatidylserine Floppase Activity Sphingolipid Floppase Activity Cholesterol Homeostasis Protein Insertion Into Mitochondrial Inner Membrane From Matrix Helper T Cell Diapedesis Chordate Pharynx Development T Cell Receptor Signaling Pathway Nuclear Receptor-mediated Signaling Pathway Cerebellar Neuron Development Antigen Receptor-mediated Signaling Pathway Hormone-mediated Signaling Pathway Protein Complex Involved In Cell Adhesion Glycerol Catabolic Process Glycerol-3-phosphate Metabolic Process Glycerol Kinase Activity Glycerol-3-phosphate Biosynthetic Process Regulation Of Lipid Kinase Activity Error-free Translesion Synthesis Negative Regulation Of Protein Autophosphorylation Oviduct Epithelium Development Uterine Epithelium Development Response To 1-oleoyl-sn-glycerol 3-phosphate Lipoprotein Biosynthetic Process Phosphatidylcholine Floppase Activity Lipid Homeostasis Parathyroid Gland Development Negative Regulation Of Regulatory T Cell Differentiation
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